Results 31 to 40 of about 22,662 (208)

Altered sterol metabolism in budding yeast affects mitochondrial iron–sulfur (Fe-S) cluster synthesis [PDF]

, 2018
Ergosterol synthesis is essential for cellular growth and viability of the budding yeast Saccharomyces cerevisiae, and intracellular sterol distribution and homeostasis are therefore highly regulated in this species. Erg25 is an iron-containing C4-methyl
Bard, Martin, Bhuiyan, Shah Alam, Chen, Opal S., Cox, James E., Kaplan, Jerry, Li, Liangtao, Natarajan, Selvamuthu K., Ward, Diane M.   +7 more
core   +1 more source

Overexpression or Deletion of Ergosterol Biosynthesis Genes Alters Doubling Time, Response to Stress Agents, and Drug Susceptibility in Saccharomyces cerevisiae

mBio, 2018
Ergosterol (ERG) is a critical sterol in the cell membranes of fungi, and its biosynthesis is tightly regulated by 25 known enzymes along the ERG production pathway.
Somanon Bhattacharya, Brooke D. Esquivel, Theodore C. White   +2 more
doaj   +1 more source

Requirement for ergosterol in V-ATPase function underlies antifungal activity of azole drugs. [PDF]

PLoS Pathogens, 2010
Ergosterol is an important constituent of fungal membranes. Azoles inhibit ergosterol biosynthesis, although the cellular basis for their antifungal activity is not understood.
Yong-Qiang Zhang, Soledad Gamarra, Guillermo Garcia-Effron, Steven Park, David S Perlin, Rajini Rao   +5 more
doaj   +1 more source

Coordinated Regulation of Membrane Homeostasis and Drug Accumulation by Novel Kinase STK-17 in Response to Antifungal Azole Treatment

Microbiology Spectrum, 2022
The emergence of antifungal resistance, especially to the most widely used azole class of ergosterol biosynthesis inhibitors, makes fungal infections difficult to treat in clinics and agriculture. When exposed to azoles, fungi can make adaptive responses
Chengcheng Hu, Mi Zhou, Xianhe Cao, Wei Xue, Zhenying Zhang, Shaojie Li, Xianyun Sun   +6 more
doaj   +1 more source

Ras hyperactivation versus overexpression : Lessons from Ras dynamics in Candida albicans [PDF]

, 2018
We thank Prof. Neta Dean for the CIp10ADH1-Cherry plasmid and Prof. Aaron Mitchell for the BWP17 strain. We gratefully acknowledge Prof. Sudipta Maiti, TIFR, Mumbai, India for providing the data acquisition software.
Haokip, Dominic T, Jain, Priyanka, Khan, Mohammad Firoz, Komath, Sneha Sudha, Pal, Nibedita, Pratyusha, Vavilala A, Sen, Sobhan, Sethi, Subhash Chandra, Singh, Sneh Lata, Victoria, Guiliana Soraya, Yadav, Bhawna   +10 more
core   +3 more sources

Diatoms synthesize sterols by inclusion of animal and fungal genes in the plant pathway [PDF]

, 2020
Diatoms are ubiquitous microalgae that have developed remarkable metabolic plasticity and gene diversification. Here we report the first elucidation of the complete biosynthesis of sterols in the lineage.
, Angela, d’Ippolito, Giuliana, Fontana, Angelo, GALLO, CARMELA, LANDI, SIMONE, MANZO, EMILIANO, Nuzzo, Genoveffa, Sardo &   +7 more
core   +1 more source

Modeling and visualizing uncertainty in gene expression clusters using Dirichlet process mixtures [PDF]

, 2009
Although the use of clustering methods has rapidly become one of the standard computational approaches in the literature of microarray gene expression data, little attention has been paid to uncertainty in the results obtained. Dirichlet process mixture (
De la Cruz, Bernard J., Ghahramani, Zoubin, Rasmussen, Carl Edward, Wild, David L.   +3 more
core   +1 more source

Regulation of High-Affinity Iron Acquisition, Including Acquisition Mediated by the Iron Permease FtrA, Is Coordinated by AtrR, SrbA, and SreA in Aspergillus fumigatus

mBio, 2023
Iron acquisition is crucial for virulence of the human pathogen Aspergillus fumigatus. Previous studies indicated that this mold regulates iron uptake via both siderophores and reductive iron assimilation by the GATA factor SreA and the SREBP regulator ...
Annie Yap, Ricarda Volz, Sanjoy Paul, W. Scott Moye-Rowley, Hubertus Haas   +4 more
doaj   +1 more source

Impact of Membrane Lipids on UapA and AzgA Transporter Subcellular Localization and Activity in Aspergillus nidulans

Journal of Fungi, 2021
Recent biochemical and biophysical evidence have established that membrane lipids, namely phospholipids, sphingolipids and sterols, are critical for the function of eukaryotic plasma membrane transporters.
Mariangela Dionysopoulou, George Diallinas   +1 more
doaj   +1 more source

Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts. [PDF]

, 2015
Organelle contact sites perform fundamental functions in cells, including lipid and ion homeostasis, membrane dynamics, and signaling. Using a forward proteomics approach in yeast, we identified new ER-mitochondria and ER-vacuole contacts specified by an
Murley, Andrew, Nunnari, Jodi, Prinz, William A, Sarsam, Reta D, Toulmay, Alexandre, Yamada, Justin   +5 more
core   +2 more sources