Results 141 to 142 of about 1,604 (142)

Effect of ERN1 knockdown on the expression of MAP3K5, MAP4K3, CIB1, RIPK1, and RIPK2 genes in U87 glioma cells and its hypoxic regulation

Journal of Investigational Biochemistry, 2014
ERN1 (endoplasmic reticulum to nucleus signaling 1)-mediated signaling pathway plays an important role in glioma growth. We studied the possible role of protein kinases MAP4K3, MAP3K5, RIPK1, and RIPK2 as well as protein kinase interacting protein CIB1 in suppression of U87 glioma cell proliferation upon ERN1 knockdown.
Dmytro Minchenko, Taia Bakalets, Daria Tzymbal, Oksana Ratushna, Yulia Bashta, Olelsandr Minchenko   +5 more
openaire   +1 more source

Knockdown of ERN1 disturbs the expression of phosphoserine aminotransferase 1 and related genes in glioblastoma cells

Archives of Biochemistry and Biophysics
Endoplasmic reticulum stress and synthesis of serine are essential for tumor growth, but the mechanism of their interaction is not clarified yet. The overarching goal of this work was to investigate the impact of ERN1 (endoplasmic reticulum to nucleus signaling 1) inhibition on the expression of serine synthesis genes in U87MG glioblastoma cells ...
Oleksandr H. Minchenko, Myroslava Y. Sliusar, Yevgen P. Khikhlo, Oleh V. Halkin, Yuliia M. Viletska, Olena O. Khita, Dmytro O. Minchenko   +6 more
openaire   +2 more sources