Results 41 to 50 of about 1,846,959 (284)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Advanced Modeling and Simulation in Engineering Sciences, 2020 Reduced order methods are powerful tools for the design and analysis of sophisticated systems, reducing computational costs and speeding up the development process.
Jonatha Reis +3 more
doaj +1 more source
Nonasymptotic bounds on the mean square error for MCMC estimates via renewal techniques [PDF]
, 2011 The Nummellin’s split chain construction allows to decompose a Markov chain Monte Carlo (MCMC) trajectory into i.i.d. "excursions". Regenerative MCMC algorithms based on this technique use a random number of samples.
Miasojedow, Błażej +2 more
core
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
MSE lower bounds for deterministic parameter estimation [PDF]
, 2010 This paper presents a simple approach for deriving computable lower bounds on the MSE of deterministic parameter estimators with a clear interpretation of the bounds.
Chaumette, Eric +5 more
core
Estimates of the Approximation Error Using Rademacher Complexity: Learning Vector-Valued Functions [PDF]
, 2008 For certain families of multivariable vector-valued functions to be approximated, the accuracy of approximation schemes made up of linear combinations of computational units containing adjustable parameters is investigated.
Gnecco Giorgio +7 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Quantum metrology with open dynamical systems
New Journal of Physics, 2013 This paper studies quantum limits to dynamical sensors in the presence of decoherence. A modified purification approach is used to obtain tighter quantum detection and estimation error bounds for optical phase sensing and optomechanical force sensing ...
Mankei Tsang
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source