Results 61 to 70 of about 82,940 (314)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Numerical methods for singularly perturbed elliptic problems containing two perturbation parameters

Mathematical Modelling and Analysis, 2006
A priori parameter explicit bounds on the derivatives of the solution of a two parameter singularly perturbed elliptic problem in two space dimensions are presented. These bounds are used to establish parameter uniform error bounds for a numerical method
E. O'Riordan, M. L. Pickett, G. I. Shishkin   +2 more
doaj   +1 more source

Error Bounds for Lagrange Interpolation

Journal of Approximation Theory, 1995
Consider an interpolation of functions \(f\in W_ \infty^ m [a,b]\) by Lagrange polynomials \(\ell_{m-1}\), \(\Delta(f)\) of degree \(m-1\) at the mesh \(\Delta\) of the interpolating nodes \(\{t_ j\}^ m_ 1\). Error bounds due to this approximation is evaluated as \[ L_{m,k} (\Delta)= \sup_{x\in [a,b]} L_{m,k} (\Delta,x)= {\textstyle {1\over m ...
openaire   +1 more source

Quantum error detection .II. Bounds [PDF]

IEEE Transactions on Information Theory, 2000
In Part II we show that there exist quantum codes whose probability of undetected error falls exponentially with the length of the code and derive bounds on this exponent.The lower (existence) bound for stabilizer codes is proved by a counting argument for classical self-orthogonal quaternary codes.
Alexei E. Ashikhmin, Alexander Barg, Emanuel Knill, Simon Litsyn   +3 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Two New Families of Local Asymptotically Minimax Lower Bounds in Parameter Estimation

Entropy
We propose two families of asymptotically local minimax lower bounds on parameter estimation performance. The first family of bounds applies to any convex, symmetric loss function that depends solely on the difference between the estimate and the true ...
Neri Merhav
doaj   +1 more source

Optimal Stable Approximation for the Cauchy Problem for Laplace Equation

Advances in Mathematical Physics, 2016
Cauchy problem for Laplace equation in a strip is considered. The optimal error bounds between the exact solution and its regularized approximation are given, which depend on the noise level either in a Hölder continuous way or in a logarithmic ...
Hongfang Li, Feng Zhou
doaj   +1 more source

Direct Analysis of Zero-Noise Extrapolation: Polynomial Methods, Error Bounds, and Simultaneous Physical-Algorithmic Error Mitigation [PDF]

Quantum
Zero-noise extrapolation (ZNE) is a widely used quantum error mitigation technique that artificially amplifies circuit noise and then extrapolates the results to the noise-free circuit.
Pegah Mohammadipour, Xiantao Li
doaj   +1 more source

A Computational Method for Subdivision Depth of Ternary Schemes

Mathematics, 2020
Subdivision schemes are extensively used in scientific and practical applications to produce continuous shapes in an iterative way. This paper introduces a framework to compute subdivision depths of ternary schemes.
Faheem Khan, Ghulam Mustafa, Aamir Shahzad, Dumitru Baleanu, Maysaa M. Al-Qurashi   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source