Results 61 to 70 of about 1,846,959 (284)

Quantum error detection .II. Bounds [PDF]

IEEE Transactions on Information Theory, 2000
In Part II we show that there exist quantum codes whose probability of undetected error falls exponentially with the length of the code and derive bounds on this exponent.The lower (existence) bound for stabilizer codes is proved by a counting argument for classical self-orthogonal quaternary codes.
Alexei E. Ashikhmin, Alexander Barg, Emanuel Knill, Simon Litsyn   +3 more
openaire   +3 more sources

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Numerical methods for singularly perturbed elliptic problems containing two perturbation parameters

Mathematical Modelling and Analysis, 2006
A priori parameter explicit bounds on the derivatives of the solution of a two parameter singularly perturbed elliptic problem in two space dimensions are presented. These bounds are used to establish parameter uniform error bounds for a numerical method
E. O'Riordan, M. L. Pickett, G. I. Shishkin   +2 more
doaj   +1 more source

A Computational Method for Subdivision Depth of Ternary Schemes

Mathematics, 2020
Subdivision schemes are extensively used in scientific and practical applications to produce continuous shapes in an iterative way. This paper introduces a framework to compute subdivision depths of ternary schemes.
Faheem Khan, Ghulam Mustafa, Aamir Shahzad, Dumitru Baleanu, Maysaa M. Al-Qurashi   +4 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Two New Families of Local Asymptotically Minimax Lower Bounds in Parameter Estimation

Entropy
We propose two families of asymptotically local minimax lower bounds on parameter estimation performance. The first family of bounds applies to any convex, symmetric loss function that depends solely on the difference between the estimate and the true ...
Neri Merhav
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Optimal Stable Approximation for the Cauchy Problem for Laplace Equation

Advances in Mathematical Physics, 2016
Cauchy problem for Laplace equation in a strip is considered. The optimal error bounds between the exact solution and its regularized approximation are given, which depend on the noise level either in a Hölder continuous way or in a logarithmic ...
Hongfang Li, Feng Zhou
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source