Results 71 to 80 of about 82,940 (314)
Open Mathematics, 2017 Some new error bounds for the linear complementarity problems are obtained when the involved matrices are weakly chained diagonally dominant B-matrices. Numerical examples are given to show the effectiveness of the proposed bounds.
Sun Deshu, Wang Feng
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Bounds for distribution functions of sums of squares and radial errors
International Journal of Mathematics and Mathematical Sciences, 1991 Bounds are found for the distribution function of the sum of squares X2+Y2 where X and Y are arbitrary continuous random variables. The techniques employed, which utilize copulas and their properties, show that the bounds are pointwise best-possible when
Roger B. Nelsen, Berthold Schweizer
doaj +1 more source
Improved error bounds for approximations to the stop loss transform of compound distributions. [PDF]
In the present note we deduce a class of bounds for the difference between the stop loss transforms of two compound distributions with the same severity distribution. The class contains bounds of any degree of accuracy in the sense that the bounds can be
Sundt, B, Dhaene, Jan
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
On truncations for weakly ergodic inhomogeneous birth and death processes
International Journal of Applied Mathematics and Computer Science, 2014 We investigate a class of exponentially weakly ergodic inhomogeneous birth and death processes. We consider special transformations of the reduced intensity matrix of the process and obtain uniform (in time) error bounds of truncations. Our approach also
Zeifman Alexander +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Error Analysis of Fixed-Gain AF Relaying with MRC Over Nakagami-m Fading Channels [PDF]
Radioengineering, 2016 This article investigates the error performance of wireless communication systems that employ binary modulations and Amplify-and-Forward (AF) relaying over flat Nakagami-m faded links with maximum ratio combining (MRC) at destination.
S. H. Alvi, S. Wyne
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source