Results 91 to 100 of about 655,974 (311)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Enhanced MMSE channel estimation using timing error statistics for wireless OFDM systems [PDF]

, 2004
Estimation and tracking of the frequency-selective time-varying channel response is a challenging task for wireless communication systems incorporating coherent OFDM.
Jayalath, Dhammika, Athaudage, Chandranath R. N.   +1 more
core   +1 more source

Assessing the Performance of Exchange‐Correlation Density Functionals in Describing the Iron‐Catalyzed Ammonia Synthesis System

ChemistryEurope
Density functional theory (DFT) has been widely employed for elucidating mechanistic aspects of heterogeneous catalysis. However, the accuracy of DFT calculations relies heavily on selecting an exchange‐correlation (XC) functional that correctly ...
Evangelos Smith, Marc Figueras‐Valls, Manos Mavrikakis   +2 more
doaj   +1 more source

Conformal symplectic and constraint-preserving model order reduction of constrained conformal Hamiltonian systems

Applied Mathematics in Science and Engineering
Dissipative and constrained dynamical systems model various physical phenomena comprising damping and constraining forces. These forces give rise to specific geometric properties of the dynamical system's governing equations. In this paper, we reduce and
Vidushi Sachan, Ashish Bhatt
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

An Algorithm Based on Compute Unified Device Architecture for Estimating Covering Functionals of Convex Bodies

Axioms
In Chuanming Zong’s program to attack Hadwiger’s covering conjecture, which is a longstanding open problem from Convex and Discrete Geometry, it is essential to estimate covering functionals of convex bodies effectively. Recently, He et al. and Yu et al.
Xiangyang Han, Senlin Wu, Longzhen Zhang
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effect of Camera Parameters Error on the Precision of Visual Pose Estimation [PDF]

, 2007
In this paper, the relation between the error of the camera parameters calibrated and pose measurement precision is analyzed in order to enhance the precision of model-based pose estimation from monocular vision.
Hao YM(郝颖明), Zhou J(周静), He L(何雷), Zhu F(朱枫)   +3 more
core  

An operational collocation based on the Bell polynomials for solving high order Volterra integro-differential equations [PDF]

Journal of Mahani Mathematical Research
In this paper, an operational matrix method based on the Bell polynomials  has been presented to find approximate solutions of high-order Volterra integro-differential equations.
Najmeh Kasaei, Esmail Hesameddini, Mohammad Nabati   +2 more
doaj   +1 more source

ERROR ESTIMATION AND ADAPTIVITY IN ELASTOPLASTICITY

International Journal for Numerical Methods in Engineering, 1996
Summary: A method is developed to control the parameters of a finite element computation for time-dependent material models. To evaluate discretization errors, we use a global error measure in constitutive relation based on Drucker's inequality. This error includes, over the studied time interval, the error of the finite element model and the error of ...
Gallimard, L., Ladevèze, Pierre, Pelle, Jean-Pierre   +2 more
openaire   +3 more sources