Results 121 to 130 of about 783,980 (293)
DobleleEste estudio explora las características y dificultades que afrontan los estudiantes belgas francófonos en el aprendizaje del castellano como lengua extranjera en la Universidad de Mons (UMONS).
Javier Acero Marín +1 more
doaj +1 more source
Uso de plantilla para la preparación de los artículos en revista científica [PDF]
Revista Ingeniería UC, 2018 El trabajo de edición de una revista requiere de mucha dedicación, es una labor que hay que desarrollar en equipo y donde la falla de cualquier eslabón de la cadena repercute en la imagen de todos.
Jesús J. Jiménez Grimán +2 more
doaj
Técnicas de ARQ en un esquema de acceso por paquetes DS-CDMA [PDF]
, 1998 Peer ReviewedPostprint (published ...
Agustí Comes, Ramon +2 more
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
El concepto de dimensión: errores y dificultades [PDF]
, 2008 El documento describe algunos errores y dificultades en relación con el objeto matemático dimensión resultado de una experiencia investigativa del grupo fractales DMA!UPN.
Orjuela, Claudia +2 more
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source
Financial forecasts of SMEs in IPOs: fact or fiction? [PDF]
, 2015 Este artículo valora el proceso de previsión financiera de las pequeñas y medianas empresas (PYME) en sus salidas a bolsa. Específicamente, se analiza la calidad de las previsiones de beneficios realizadas y se exploran los factores que determinan la ...
Alonso Canales, Fernando +1 more
core
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source