Results 111 to 120 of about 179,010,438 (302)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
, 2010 Experimental measurements are never perfect, even with sophisticated modern instruments. One of the fundamental problems in signal measurement is distinguishing the noise from the signal.
Majeti, Srivatsa Subba Rao
core
Indoor Positioning of Visible Light Communication based on Transformer Model
Guangtongxin yanjiuObjectiveIn the multipath propagation scenario of indoor visible light communication, Inter-Symbol Interference (ISI) leads to low precision of indoor visible light positioning due to low received signal strength.
YAO Yao, ZHU Yali, SHAO Xinyu
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
ETRI JournalThe information interaction and positioning technology based on commercialWi-Fi plays a crucial role in expanding the applications for the Internet ofThings and smart homes.
Jin Huang, Xuejie Hu, Yue Tian
doaj +1 more source
Identification of Abnormal UGW Signals Using Multi-Scale Progressive Reconstruction Network
AcousticsThe use of ultrasonic guided waves (UGWs) is an efficient damage monitoring technique. Due to their characteristics of a wide monitoring range and low power consumption, UGWs have been widely applied in various structural health monitoring fields.
Yangkun Zou +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
The error analysis of narrow-band receiving frequency-modulated signals
Известия высших учебных заведений России: Радиоэлектроника, 2015 It's showed that limitation of the stripe passing in the time of the reception the frequency-modulation signal leads to bad changes of amplitude and frequency in the exiting signal, value of which is depended from meaning of the angle modulation.
openaire +1 more source