Results 31 to 40 of about 116,869 (268)

En réponse à un article de J.D. Bengtson

open access: yesFontes Linguae Vasconum, 1997
Un certain nombre de comparatistes tentent de relier le basque à d’autres langues dans le cadre de grandes super-familles (phyla) comme le Nostratique ou le Sino- ou Dene-Caucasien. J.D. Bengtson est l’un d’entre-eux. Il y a probablement du vrai dans ce
Michel Morvan
doaj   +1 more source

Macrophage‐to‐Myofibroblast Transdifferentiation Contributes to Pulmonary Fibrosis via the MERTK‐SPP1‐SRC‐TKS5 Signaling Axis

open access: yesAdvanced Science, EarlyView.
MERTK is upregulated in fibrotic macrophages and regulates the expression and activity of SRC and TKS5 through SPP1, mediating transdifferentiation of macrophages‐to‐myofibroblasts (MMT) and promoting pulmonary fibrosis. The figure was created with BioRender.com.
Yungeng Wei   +3 more
wiley   +1 more source

Remote sensing and ecosystem modeling to simulate terrestrial carbon fluxes

open access: yesRevista de Teledetección, 2019
The main goal of this thesis is the establishment of a framework to analyze the forest ecosystems in peninsular Spain in terms of their role in the carbon cycle.
Sergio Sánchez-Ruiz
doaj   +1 more source

Diagnosis and Prioritization of Vulnerable Areas of Urban Ecosystem Regulation Services

open access: yesLand, 2022
Rapid urbanization and population growth have led to drastic degradation of urban ecosystem regulation services (ERS). Urgently needed is the identification of vulnerable areas where ERS are being intensively deteriorated, and preparation of measures to ...
Dongwoo Lee, Kyushik Oh, Jungeun Suh
doaj   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu   +20 more
wiley   +1 more source

Comprehensive analysis of the biological functions of endoplasmic reticulum stress in prostate cancer

open access: yesFrontiers in Endocrinology, 2023
IntroductionEndoplasmic reticulum stress (ERS) has sizeable affect on cancer proliferation, metastasis, immunotherapy and chemoradiotherapy resistance.
Shengren Cen   +8 more
doaj   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

open access: yesAdvanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li   +14 more
wiley   +1 more source

Comprehensive Analysis of Endoplasmic Reticulum Stress in Intracranial Aneurysm

open access: yesFrontiers in Cellular Neuroscience, 2022
BackgroundAberrant endoplasmic reticulum stress (ERS) plays an important role in multiple cardiovascular diseases. However, their implication in intracranial aneurysms (IAs) remains unclear.
Bo Chen   +10 more
doaj   +1 more source

Headache in ER

open access: yesEmergency Care Journal, 2007
In evaluating a headache patient, the first task is to identify or exclude secondary headaches based on the history, and the general medical as well as neurological examinations. Physical and neurological examinations are mandatory, overall in emergency room setting. If suspicious features are present, diagnostic testing may also be necessary.
Pietro Cortelli, Marco Aguggia
openaire   +4 more sources

Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung

open access: yesAdvanced Science, EarlyView.
Acidic heating converts hemoglobin into β‐sheet‐rich fibrils with positively charged surfaces. These hemoglobin fibrils electrostatically complex IL‐11 scFv mRNA, selectively bind circulating platelets, and hitchhike to the lung, where they are enriched in fibroblasts.
Xihua Liu   +11 more
wiley   +1 more source

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