Results 61 to 70 of about 29,567 (256)

An important class of intron retention events in human erythroblasts is regulated by cryptic exons proposed to function as splicing decoys

bioRxiv, 2018
During terminal erythropoiesis, the splicing machinery in differentiating erythroblasts executes a robust intron retention (IR) program that impacts expression of hundreds of genes.
M. Parra, Benjamin W. Booth, Richard Weiszmann, Brian A. Yee, Gene W. Yeo, James B. Brown, S. Celniker, J. Conboy   +7 more
semanticscholar   +1 more source

Suppression of erythropoiesis by actinomycin D. 3. The effect of actinomycin D on the hemoglobin level of bone marrow erythrocytes and erythroblasts [PDF]

, 1969
For the purpose of revealing whether or not hemoglobin synthesis is inhibited by the AMD, the author estimated the hemoglobin level of AMD treated anilmals by microspectrophotometer, and found that the hemoglobin levels of all the developmental stages of
Okada, Shigeru
core   +1 more source

Transferrin receptor 1 is required for enucleation of mouse erythroblasts during terminal differentiation

FEBS Open Bio, 2019
Enucleation is the process whereby the nucleus is extruded from the erythroblast during late stage mammalian erythropoiesis. However, the specific signaling pathways involved in this process remain unclear.
M. Aoto, A. Iwashita, Kanako Mita, N. Ohkubo, Y. Tsujimoto, N. Mitsuda   +5 more
semanticscholar   +1 more source

Preleukemia: hematological disorders prior to onset of leukemia [PDF]

, 1975
Published data on Japanese leukemia patients with a preleukemic hematological disorder were assessed. The reexamined cases were from the "Japona Centra Revuo Medicina" reported during the period from 1952 to 1971.
Hiraki, Kiyoshi, Kitajima, Koichi, Mikochi, Hiroshi, Nakanishi, Toshio, Sakato, Junya, Takahashi, Isao   +5 more
core   +1 more source

The accumulation of miR-125b-5p is indispensable for efficient erythroblast enucleation

Cell Death and Disease, 2022
Erythroblast enucleation is a precisely regulated but not clearly understood process. Polycythemia shows pathological erythroblast enucleation, and we discovered a low miR-125b-5p level in terminal erythroblasts of patients with polycythemia vera (PV ...
Fang Fang, Lei Xu, Liqing Liang, Mingyi Qu, Hailei Yao, Wen Yue, Lin Chen, Dongli Chen, Zeng Fan, Lijuan He, Xue Nan, Huanhuan Zhang, Xiaoyan Xie, Xuetao Pei   +13 more
doaj   +1 more source

Acute Hepatic Porphyrias: Review and Recent Progress. [PDF]

, 2019
The acute hepatic porphyrias (AHPs) are a group of four inherited diseases of heme biosynthesis that present with episodic, acute neurovisceral symptoms.
Andant, Anderson, Andersson, Badawy, Balwani, Bissell, Bissell, Bloomer, Bonkovsky, Bonkovsky, Bonkovsky, Bonkovsky, Bonkowsky, Bonkowsky, Bonkowsky, Bylesjo, Chen, D’Avola, Ferrer, Glueck, Handschin, Jeans, Lambrecht, Lane, Marsden, McGuire, Pallet, Sardh, Sardh, Shen, Singal, Stein, Stewart, Tchernitchko, Wahlin, Watson, Watson, Willandt, Wu, Yarra, Yasuda   +40 more
core   +1 more source

Erythroblast enucleation

Haematologica, 2010
Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal ...
openaire   +3 more sources

Revealing nascent proteomics in signaling pathways and cell differentiation. [PDF]

, 2018
Regulation of gene expression at the level of protein synthesis is a crucial element in driving how the genetic landscape is expressed. However, we are still limited in technologies that can quantitatively capture the immediate proteomic changes that ...
Burlingame, Alma L, Chalkley, Robert J, Forester, Craig M, Oses-Prieto, Juan A, Phillips, Nancy J, Ruggero, Davide, Urisman, Anatoly, Zhang, Li, Zhao, Qian   +8 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Reactivating Fetal Hemoglobin Expression in Human Adult Erythroblasts Through BCL11A Knockdown Using Targeted Endonucleases. [PDF]

, 2016
We examined the efficiency, specificity, and mutational signatures of zinc finger nucleases (ZFNs), transcriptional activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 systems designed to
Bjurström, Carmen F, Cooper, Aaron, Hollis, Roger P, Kaufman, Michael, Kohn, Donald B, Kuo, Caroline, Lai, Stephen, Lill, Georgia R, Mojadidi, Michelle, Phillips, John, Urbinati, Fabrizia, Wang, Xiaoyan   +11 more
core   +3 more sources