Results 41 to 50 of about 23,516 (234)

Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of F- and A-erythroblasts.

Blood, 2020
Reversing the developmental switch from fetal (HbF, α2γ2) to adult (HbA, α2β2) hemoglobin is an important therapeutic approach in sickle cell disease (SCD) and β-thalassemia.
Eugene Khandros, Peng Huang, Scott A. Peslak, Malini Sharma, O. Abdulmalik, B. Giardine, Zhe Zhang, C. Keller, R. Hardison, G. Blobel   +9 more
semanticscholar   +1 more source

The majority of the in vitro erythroid expansion potential resides in CD34− cells, outweighing the contribution of CD34+ cells and significantly increasing the erythroblast yield from peripheral blood samples

Haematologica, 2010
The study of human erythropoiesis in health and disease requires a robust culture system that consistently and reliably generates large numbers of immature erythroblasts that can be induced to differentiate synchronously.
Emile van den Akker, Timothy J. Satchwell, Stephanie Pellegrin, Geoff Daniels, Ashley M. Toye   +4 more
doaj   +1 more source

Cytological evaluation of the influence of high and low doses of bisphenol A on an erythroblastic cell line of porcine bone marrow

Journal of Veterinary Research, 2018
Introduction: Bisphenol A (BPA) is a substance widely used in industry for the production of polycarbonates and epoxy resins used in packaging and containers for beverages, contact lenses, compact discs (CDs), window panes, and many other elements.
Snarska Anna, Wysocka Dominika, Rytel Liliana, Makowska Krystyna, Gonkowski Sławomir   +4 more
doaj   +1 more source

No Mitoses in Basophilic Erythroblasts

Experimental Biology and Medicine, 1974
SummaryIn the rabbit, under conditions in which mitoses accumulated in the acidophilic erythroblasts, none were observed in the basophilic erythroblasts. On the basis of certain assumptions, the basophilic erythroblasts were divided into two size classes: of average long diameters (as measured here) 10.3 and 8.4 nm.
H, Borsook, S, Jiggins
openaire   +2 more sources

THE METABOLISM OF HUMAN ERYTHROBLASTS [PDF]

Journal of Clinical Investigation, 1936
The metabolism of human nucleated red blood cells has not previously been determined because of difficulties in procuring material. In most anemias the number of nucleated erythrocytes in the blood is so small in relation to the number of non-nucleated erythrocytes that the metabolism of the former is obscured by that of the latter.
openaire   +2 more sources

A mechanism of ineffective erythropoiesis in β-thalassemia/Hb E disease

Haematologica, 2010
Background Cells respond to stress stimuli through a number of response pathways, of which one of the most important and well characterized is the unfolded protein response.
Pathrapol Lithanatudom, Amporn Leecharoenkiat, Tirawat Wannatung, Saovaros Svasti, Suthat Fucharoen, Duncan R. Smith   +5 more
doaj   +1 more source

Stage Specific Expression Pattern of Alpha-Hemoglobin-Stabilizing-Protein (AHSP) Portrayed in Erythroblast Chronology

Methods and Protocols, 2020
During erythropoiesis, the molecular chaperone alpha-hemoglobin-stabilizing protein (AHSP) sequesters free alpha-hemoglobin (αHb) and prevents precipitation of excess αHb.
Julia Walczak, Maria D. Camargo Johnson, Kuzhali Muthumalaiappan   +2 more
doaj   +1 more source

Ultrastructural characteristics of erythroid cells in congenital dyserythropoietic anemia type II, with a focus on peripheral cisternae and double membranes

Blood Science, 2023
Peripheral cisternae and double membranes (PCDMs) in erythroid cells are a landmark of type II congenital dyserythropoietic anemia (CDA). To gain further insights into the mechanism of dyserythropoiesis, erythroblasts and erythrocytes in bone marrow were
Yong-Xin Ru, Shu-Xu Dong, Jing Liu, Brian Eyden   +3 more
doaj   +1 more source

Mitapivat metabolically reprograms human β-thalassemic erythroblasts, increasing their responsiveness to oxidation

Blood Advances
Key Points • β-thal erythroblasts display persistent compensatory expression of PKM2.• Mitapivat mitigates Cys-oxidative damage to β-thal erythroblast proteins, with normalization of Prdx2 subcellular compartmentalization.
A. Siciliano, A. D'alessandro, A. Matte, Giovanni Bisello, Mariarita Bertoldi, Monika Dzieciatkowska, Amy Argabright, Richard Huot Pozzetto, V. Riccardi, A. Mattarei, A. Ongaro, Jacopo Ceolan, R. Russo, Leonardo Rivadeneyra, Megan Wind-Rotolo, A. Iolascon, Carlo Brugnara, L. De Franceschi   +17 more
semanticscholar   +1 more source

Importância clínica da dosagem de lactato e contagem de eritroblastos no sangue colhido no segmento placentário da veia umbilical para o diagnóstico de hipóxia-isquemia em prematuros Clinical value of lactate measurement and nucleated red blood cell counts in the placental segment of the umbilical vein of premature newborns for diagnosis of hypoxia-ischemia

Jornal de Pediatria, 2007
OBJETIVO: Determinar a validade clínica das dosagens de lactato e contagem de eritroblastos quando comparados com o excesso de bases (EB) em sangue do segmento placentário da veia umbilical de prematuros. MÉTODOS: foram colhidas amostras de 25 prematuros,
Yvi Gea, Orlei Araujo, Luiz Vicente R. Silva   +2 more
doaj   +1 more source