Results 41 to 50 of about 13,873 (221)

Importância clínica da dosagem de lactato e contagem de eritroblastos no sangue colhido no segmento placentário da veia umbilical para o diagnóstico de hipóxia-isquemia em prematuros Clinical value of lactate measurement and nucleated red blood cell counts in the placental segment of the umbilical vein of premature newborns for diagnosis of hypoxia-ischemia

Jornal de Pediatria, 2007
OBJETIVO: Determinar a validade clínica das dosagens de lactato e contagem de eritroblastos quando comparados com o excesso de bases (EB) em sangue do segmento placentário da veia umbilical de prematuros. MÉTODOS: foram colhidas amostras de 25 prematuros,
Yvi Gea, Orlei Araujo, Luiz Vicente R. Silva   +2 more
doaj   +1 more source

ISG15 modulates development of the erythroid lineage. [PDF]

PLoS ONE, 2011
Activation of erythropoietin receptor allows erythroblasts to generate erythrocytes. In a search for genes that are up-regulated during this differentiation process, we have identified ISG15 as being induced during late erythroid differentiation.
Ana Leticia Maragno, Martine Pironin, Hélène Alcalde, Xiuli Cong, Klaus-Peter Knobeloch, Frederic Tangy, Dong-Er Zhang, Jacques Ghysdael, Christine Tran Quang   +8 more
doaj   +1 more source

CIRCULATING HEMATOPOIETIC STEM AND PROGENITOR CELLS AND ERYTHROBLASTS COUNTING IS INCREASED IN PATIENTS WITH SICKLE CELL ANEMIA

Hematology, Transfusion and Cell Therapy, 2023
Due to the challenges associated with accessing bone marrow samples from individuals with sickle cell anemia (SCA), hematopoiesis in the context of this disease remains less studied compared to other pathologies.
J Milhomens, A Godard, J Grenier, M De-Grandis, DT Covas, W El-Nemer, S Kashima   +6 more
doaj   +1 more source

Studies on erythropoiesis II. In vitro studies on red cell proliferation under varied oxygen tension

, 1964
For the purpose to reveal the mechanism of the stimulated erythropoiesis in anemic condition, the author observed the numerical changes of the erythroblasts from normal rabbit bone marrow cultured under the environment of varied oxygen tensions, and ...
Shibata, Takashi
core   +1 more source

The accumulation of miR-125b-5p is indispensable for efficient erythroblast enucleation

Cell Death and Disease, 2022
Erythroblast enucleation is a precisely regulated but not clearly understood process. Polycythemia shows pathological erythroblast enucleation, and we discovered a low miR-125b-5p level in terminal erythroblasts of patients with polycythemia vera (PV ...
Fang Fang, Lei Xu, Liqing Liang, Mingyi Qu, Hailei Yao, Wen Yue, Lin Chen, Dongli Chen, Zeng Fan, Lijuan He, Xue Nan, Huanhuan Zhang, Xiaoyan Xie, Xuetao Pei   +13 more
doaj   +1 more source

Erythroblast enucleation

Haematologica, 2010
Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal ...
openaire   +3 more sources

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Epo removal induces apoptosis of erythroblasts.

, 2012
A) Cytospins of 2 separate erythroblast cultures obtained after 9 days in culture in ESDL medium and of erythroblasts after 24 hour in ESDL or SDL (scale bar is 20 µM). B) Flow cytometry analysis of cell surface markers expressed by erythroblasts after 8
Ashley M. Toye (157419), Stéphanie Pellegrin (157375), Geoff Daniels (157409), Timothy J. Satchwell (157395), Emile van den Akker (157417), Bethan R. Hawley (157404), Kate J. Heesom (157385)   +6 more
core   +1 more source

Correction of Ineffective Erythropoiesis and Normalization of Iron Homeostasis After Exagamglogene Autotemcel in Transfusion‐Dependent β‐Thalassemia

American Journal of Hematology, EarlyView.
ABSTRACT Exagamglogene autotemcel (exa‐cel) is a one‐time, ex vivo, CRISPR‐Cas9 gene edited cell therapy approved for patients with transfusion dependent β‐thalassemia (TDT) aged 12–35 years. In a Phase 3 study (CLIMB THAL‐111), exa‐cel treatment resulted in reactivation of fetal hemoglobin and increases in total hemoglobin, leading to transfusion ...
Sujit Sheth, Selim Corbacioglu, Josu de la Fuente, Mattia Algeri, Joachim Rupprecht, Kevin H. M. Kuo, Ami J. Shah, Peter Lang, Hayley Merkeley, Ben Carpenter, Markus Y. Mapara, Robert I. Liem, Stephan Grupp, Yogi Chopra, Amanda M. Li, Janet L. Kwiatkowski, Melanie Kirby‐Allen, Maria Domenica Cappellini, Antonis Kattamis, Sakellarios Zairis, Tina Liu, William Hobbs, Haydar Frangoul, Franco Locatelli, Roland Meisel, on behalf of the CLIMB THAL‐111 and CLIMB‐131 Study Groups   +25 more
wiley   +1 more source

Leishmania donovani infection induces anemia in hamsters by differentially altering erythropoiesis in bone marrow and spleen. [PDF]

PLoS ONE, 2013
Leishmania donovani is a parasite that causes visceral leishmaniasis by infecting and replicating in macrophages of the bone marrow, spleen, and liver. Severe anemia and leucopenia is associated with the disease.
William P Lafuse, Ryan Story, Jocelyn Mahylis, Gaurav Gupta, Sanjay Varikuti, Heidi Steinkamp, Steve Oghumu, Abhay R Satoskar   +7 more
doaj   +1 more source