Results 61 to 70 of about 13,873 (221)
iMeta, EarlyView.This study presents a cross‐tissue, single‐cell/single‐nucleus transcriptomic atlas spanning from prenatal to postnatal developmental stages in pig, characterizing 83 distinct cell types from 252,033 cells. Through the construction of cross‐tissue transcriptional regulatory networks and pseudotime trajectories, we revealed that organogenesis is driven ...
Rong Zhou +8 more
wiley +1 more source
Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency
Haematologica, 2017 Iron plays the central role in oxygen transport by erythrocytes as a constituent of heme and hemoglobin. The importance of iron and heme is also to be found in their regulatory roles during erythroblast maturation.
Masahiro Kobayashi +12 more
doaj +1 more source
Cell Communication and Signaling, 2023 Anemia is the most common manifestation in myelodysplastic syndrome (MDS) patients, but the cause of ineffective hematopoiesis is not fully understood. Enucleation is an important event in the maturation process of erythroblasts. According to a series of
Chao An +5 more
doaj +1 more source
Generation of the human erythroblast-derived iPSC line UBTi001-A
Stem Cell Research, 2022 We performed reprogramming of human erythroblasts derived from CD34+ hematopoietic stem / progenitor cells of a healthy donor. CD34+ cells were differentiated in-vitro into a pure population of CD36+ erythroblasts and nucleofected with four episomal ...
Afrim Avdili +5 more
doaj +1 more source
Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis
Prenatal Diagnosis, EarlyView.ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell +6 more
wiley +1 more source
Calcium Signaling Is Required for Erythroid Enucleation. [PDF]
PLoS ONE, 2016 Although erythroid enucleation, the property of erythroblasts to expel their nucleus, has been known for 7ore than a century, surprisingly little is known regarding the molecular mechanisms governing this unique developmental process.
Christina B Wölwer +3 more
doaj +1 more source
L. donovani infection increases apoptosis of erythroblasts.
, 2013 Apoptosis of bone marrow erythroblasts was examined by flow cytometry from control non-infected hamsters and L. donovani infected hamsters. Apoptosis was determined by Annexin-V binding (A) and the TUNEL Assay (B). Representative flow cytometry plots are
Steve Oghumu (393264) +7 more
core +1 more source
British Journal of Haematology, EarlyView.Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki +8 more
wiley +1 more source
Perspectives In Medical Research, 2017 Acute Erythroid Leukemia (AEL) / Acute Myeloid Leukemia M6 (AML M6) is a rare disorder of hematopoietic system and accounts for 1-3% of acute leukemia and 15% of myeloid leukemia. It is characterized by uncontrolled proliferation of erythroblasts and
Pendurthy Anoosha1 , Anandam G2 ,Preethi Soni3
doaj
Studies on Sideroblasts Part 3 The Iron Metabolism of Erythroblasts [PDF]
, 1957 By creating various changes mainly in erythroblasts of adult rabbits and by administering iron to these animals, changes in the proportion of sideroblasts have been studied comparatively; and the iron intake by erythroblasts has been examined.
Kimura, Ikuro
core