Results 61 to 70 of about 23,516 (234)

Epo removal induces apoptosis of erythroblasts.

, 2012
A) Cytospins of 2 separate erythroblast cultures obtained after 9 days in culture in ESDL medium and of erythroblasts after 24 hour in ESDL or SDL (scale bar is 20 µM). B) Flow cytometry analysis of cell surface markers expressed by erythroblasts after 8
Ashley M. Toye (157419), Stéphanie Pellegrin (157375), Geoff Daniels (157409), Timothy J. Satchwell (157395), Emile van den Akker (157417), Bethan R. Hawley (157404), Kate J. Heesom (157385)   +6 more
core   +1 more source

SOX17 Regulates Conversion of Human Fibroblasts Into Endothelial Cells and Erythroblasts by Dedifferentiation Into CD34+ Progenitor Cells

Circulation, 2017
Background: The mechanisms underlying the dedifferentiation and lineage conversion of adult human fibroblasts into functional endothelial cells have not yet been fully defined.
Lianghui Zhang, A. Jambusaria, Z. Hong, G. Marsboom, P. Toth, B. Herbert, A. Malik, J. Rehman   +7 more
semanticscholar   +1 more source

Leishmania donovani infection induces anemia in hamsters by differentially altering erythropoiesis in bone marrow and spleen. [PDF]

PLoS ONE, 2013
Leishmania donovani is a parasite that causes visceral leishmaniasis by infecting and replicating in macrophages of the bone marrow, spleen, and liver. Severe anemia and leucopenia is associated with the disease.
William P Lafuse, Ryan Story, Jocelyn Mahylis, Gaurav Gupta, Sanjay Varikuti, Heidi Steinkamp, Steve Oghumu, Abhay R Satoskar   +7 more
doaj   +1 more source

Erythroblast enucleation at a glance

Journal of Cell Science
ABSTRACT Erythroid enucleation, the penultimate step in mammalian erythroid terminal differentiation, is a unique cellular process by which red blood cells (erythrocytes) remove their nucleus and accompanying nuclear material. This complex, multi-stage event begins with chromatin compaction and cell cycle arrest and ends with generation ...
Lucas M. Newton, Velia M. Fowler, Patrick O. Humbert   +2 more
openaire   +2 more sources

Plasmodium falciparum gametocyte-infected erythrocytes do not adhere to human primary erythroblasts

Scientific Reports, 2018
Plasmodium falciparum gametocytes, the sexual stages responsible for malaria parasite transmission, develop in the human bone marrow parenchyma in proximity to the erythroblastic islands.
Gaëlle Neveu, Florian Dupuy, M. Ladli, D. Barbieri, Bernina Naissant, Cyrielle Richard, R. M. Martins, Jose-Juan Lopez-Rubio, Anna Bachmann, F. Verdier, C. Lavazec   +10 more
semanticscholar   +1 more source

Hepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts

, 2011
The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release ...
Thomas Senecal, Tiffany Tu, Hayden Ollivierre-Wilson, De-Liang Zhang, Tracey A. Rouault, Manik C. Ghosh   +5 more
core   +1 more source

A novel role for survivin in erythroblast enucleation

Haematologica, 2012
Background Nucleus free red blood cells are unique to mammals. During their terminal stage of differentiation, mammalian erythroblasts exit the cell cycle and enucleate.
Ganesan Keerthivasan, Hui Liu, Jacob M. Gump, Steven F. Dowdy, Amittha Wickrema, John D. Crispino   +5 more
doaj   +1 more source

PI3K-Akt Signal Transduction Molecules Maybe Involved in Downregulation of Erythroblasts Apoptosis and Perifosine Increased Its Apoptosis in Chronic Mountain Sickness

Medical Science Monitor, 2017
Background Chronic mountain sickness (CMS) has a higher incidence in the plateau region. The one of its principal characters is excessive erythrocytosis.
Chengyu Zhao, Zhan-Quan Li, Lin-Hua Ji, Jie Ma, R. Ge, S. Cui   +5 more
semanticscholar   +1 more source

Stat5 signaling specifies basal versus stress erythropoietic responses through distinct binary and graded dynamic modalities.

PLoS Biology, 2012
Erythropoietin (Epo)-induced Stat5 phosphorylation (p-Stat5) is essential for both basal erythropoiesis and for its acceleration during hypoxic stress. A key challenge lies in understanding how Stat5 signaling elicits distinct functions during basal and ...
Ermelinda Porpiglia, Daniel Hidalgo, Miroslav Koulnis, Abraham R Tzafriri, Merav Socolovsky   +4 more
doaj   +1 more source

miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia

Haematologica, 2018
The microRNAs miR-144 and -451 are encoded by a bicistronic gene that is strongly induced during red blood cell formation (erythropoiesis). Ablation of the miR-144/451 gene in mice causes mild anemia under baseline conditions.
Xiao Fang, Feiyang Shen, Christophe Lechauve, Peng Xu, Guowei Zhao, Jacobi Itkow, Fan Wu, Yaying Hou, Xiaohui Wu, Lingling Yu, Huiqing Xiu, Mengli Wang, Ruiling Zhang, Fangfang Wang, Yanqing Zhang, Daxin Wang, Mitchell J. Weiss, Duonan Yu   +17 more
doaj   +1 more source