Results 51 to 60 of about 23,516 (234)
ATP produced by anaerobic glycolysis is essential for enucleation of human erythroblasts.
Experimental Hematology, 2019 More than 2million human erythroblasts extrude their nuclei every second in bone marrow under hypoxic conditions (
Tatsufumi Goto +10 more
semanticscholar +1 more source
npj Regenerative Medicine, 2023 Red blood cell (RBC) generation from human pluripotent stem cells (PSCs) offers potential for innovative cell therapy in regenerative medicine as well as developmental studies.
Soo-Been Jeon +9 more
doaj +1 more source
Genomics, Proteomics & Bioinformatics, 2023 The fetal liver (FL) is the key erythropoietic organ during fetal development, but knowledge on human FL erythropoiesis is very limited. In this study, we sorted primary erythroblasts from FL cells and performed RNA sequencing (RNA-seq) analyses.
Yongshuai Han +8 more
doaj +1 more source
bioRxiv, 2018 During terminal erythropoiesis, the splicing machinery in differentiating erythroblasts executes a robust intron retention (IR) program that impacts expression of hundreds of genes.
Marilyn K. Parra +7 more
semanticscholar +1 more source
Hematology, Transfusion and Cell Therapy, 2023 Due to the challenges associated with accessing bone marrow samples from individuals with sickle cell anemia (SCA), hematopoiesis in the context of this disease remains less studied compared to other pathologies.
J Milhomens +6 more
doaj +1 more source
Haematologica, 2010 Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal ...
openaire +3 more sources
Studies on the relation between heme and nucleic acid syntheses in erythroid cell. II. Nucleic acid synthesis in erythroblast of anemic rat treated with aminopterin and bromouracil [PDF]
, 1968 With the bone marrow of anemic rats, which had received the repeated injections of phenylhydrazine once a day for three to four days, the effects of aminopterin and bromouracil on the nucleic acid metabolism of erythroblasts were observed in vivo ...
Shigehisa, Morio
core +1 more source
FEBS Open Bio, 2019 Enucleation is the process whereby the nucleus is extruded from the erythroblast during late stage mammalian erythropoiesis. However, the specific signaling pathways involved in this process remain unclear.
M. Aoto +5 more
semanticscholar +1 more source
The accumulation of miR-125b-5p is indispensable for efficient erythroblast enucleation
Cell Death and Disease, 2022 Erythroblast enucleation is a precisely regulated but not clearly understood process. Polycythemia shows pathological erythroblast enucleation, and we discovered a low miR-125b-5p level in terminal erythroblasts of patients with polycythemia vera (PV ...
Fang Fang +13 more
doaj +1 more source
ISG15 modulates development of the erythroid lineage. [PDF]
PLoS ONE, 2011 Activation of erythropoietin receptor allows erythroblasts to generate erythrocytes. In a search for genes that are up-regulated during this differentiation process, we have identified ISG15 as being induced during late erythroid differentiation.
Ana Leticia Maragno +8 more
doaj +1 more source