Results 51 to 60 of about 13,873 (221)

Therapeutic Silencing of Tmprss6 Reduces Iron‐Induced Inflammation and Prolongs Survival in MDS Mice

American Journal of Hematology, EarlyView.
ABSTRACT Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and an increased risk of progression to acute myeloid leukemia (AML). Despite advances in supportive and targeted therapies, disease‐modifying interventions remain limited.
Shahla Vilcassim, Nuttanan Pholngam, Rattanawan Thubthed, Tiwaporn Nualkaew, Saovaros Svasti, Pornthip Chaichompoo, Kai Kysenius, Peter J. Crouch, Sibylle Dames, Mona Eisermann, Alberto Martinez, Ute Schaeper, Jim Vadolas, George Grigoriadis   +13 more
wiley   +1 more source

A novel role for survivin in erythroblast enucleation

Haematologica, 2012
Background Nucleus free red blood cells are unique to mammals. During their terminal stage of differentiation, mammalian erythroblasts exit the cell cycle and enucleate.
Ganesan Keerthivasan, Hui Liu, Jacob M. Gump, Steven F. Dowdy, Amittha Wickrema, John D. Crispino   +5 more
doaj   +1 more source

Hepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts

, 2011
The iron-regulatory hormone, hepcidin, regulates systemic iron homeostasis by interacting with the iron export protein ferroportin (FPN1) to adjust iron absorption in enterocytes, iron recycling through reticuloendothelial macrophages, and iron release ...
Thomas Senecal, Tiffany Tu, Hayden Ollivierre-Wilson, De-Liang Zhang, Tracey A. Rouault, Manik C. Ghosh   +5 more
core   +1 more source

Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor

Bulletin of the Korean Chemical Society, EarlyView.
This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim, Seongu Seong, Jung‐Ae Kim, Taeyeon Kwon, Hyun Jin Kim, Jeong‐Hoon Kim, Jong Yeon Hwang, Jin Hwa Cho, Kyoungmin Choi   +8 more
wiley   +1 more source

Stat5 signaling specifies basal versus stress erythropoietic responses through distinct binary and graded dynamic modalities.

PLoS Biology, 2012
Erythropoietin (Epo)-induced Stat5 phosphorylation (p-Stat5) is essential for both basal erythropoiesis and for its acceleration during hypoxic stress. A key challenge lies in understanding how Stat5 signaling elicits distinct functions during basal and ...
Ermelinda Porpiglia, Daniel Hidalgo, Miroslav Koulnis, Abraham R Tzafriri, Merav Socolovsky   +4 more
doaj   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Bmi-1 Regulates Extensive Erythroid Self-Renewal

Stem Cell Reports, 2015
Red blood cells (RBCs), responsible for oxygen delivery and carbon dioxide exchange, are essential for our well-being. Alternative RBC sources are needed to meet the increased demand for RBC transfusions projected to occur as our population ages.
Ah Ram Kim, Jayme L. Olsen, Samantha J. England, Yu-Shan Huang, Katherine H. Fegan, Luis F. Delgadillo, Kathleen E. McGrath, Paul D. Kingsley, Richard E. Waugh, James Palis   +9 more
doaj   +1 more source

Under HEMA conditions, self-replication of human erythroblasts is limited by autophagic death.

, 2011
The number of erythroblasts generated ex-vivo under human-erythroid massive-amplification conditions by mononuclear cells from one unit of adult blood (~10(10)) are insufficient for transfusion (~10(12) red cells), emphasizing the need for studies to ...
Masiello, F, Valentina Tirelli, Whitsett, C, Migliaccio, G, Varricchio, L, FRANCO MIGLIACCIO, ANNA RITA, Francesca Masiello, Massimo Sanchez, Giovanni Migliaccio, Tirelli, V, Anna Rita Migliaccio, Carolyn Whitsett, Sanchez, M, Lilian Varricchio   +13 more
core   +1 more source

miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia

Haematologica, 2018
The microRNAs miR-144 and -451 are encoded by a bicistronic gene that is strongly induced during red blood cell formation (erythropoiesis). Ablation of the miR-144/451 gene in mice causes mild anemia under baseline conditions.
Xiao Fang, Feiyang Shen, Christophe Lechauve, Peng Xu, Guowei Zhao, Jacobi Itkow, Fan Wu, Yaying Hou, Xiaohui Wu, Lingling Yu, Huiqing Xiu, Mengli Wang, Ruiling Zhang, Fangfang Wang, Yanqing Zhang, Daxin Wang, Mitchell J. Weiss, Duonan Yu   +17 more
doaj   +1 more source

Erythroblast enucleation at a glance

Journal of Cell Science
ABSTRACT Erythroid enucleation, the penultimate step in mammalian erythroid terminal differentiation, is a unique cellular process by which red blood cells (erythrocytes) remove their nucleus and accompanying nuclear material. This complex, multi-stage event begins with chromatin compaction and cell cycle arrest and ends with generation ...
Lucas M. Newton, Velia M. Fowler, Patrick O. Humbert   +2 more
openaire   +2 more sources