Results 31 to 40 of about 11,797 (185)
Blood Science, 2023 Peripheral cisternae and double membranes (PCDMs) in erythroid cells are a landmark of type II congenital dyserythropoietic anemia (CDA). To gain further insights into the mechanism of dyserythropoiesis, erythroblasts and erythrocytes in bone marrow were
Yong-Xin Ru +3 more
doaj +1 more source
npj Regenerative Medicine, 2023 Red blood cell (RBC) generation from human pluripotent stem cells (PSCs) offers potential for innovative cell therapy in regenerative medicine as well as developmental studies.
Soo-Been Jeon +9 more
doaj +1 more source
Genomics, Proteomics & Bioinformatics, 2023 The fetal liver (FL) is the key erythropoietic organ during fetal development, but knowledge on human FL erythropoiesis is very limited. In this study, we sorted primary erythroblasts from FL cells and performed RNA sequencing (RNA-seq) analyses.
Yongshuai Han +8 more
doaj +1 more source
ISG15 modulates development of the erythroid lineage. [PDF]
PLoS ONE, 2011 Activation of erythropoietin receptor allows erythroblasts to generate erythrocytes. In a search for genes that are up-regulated during this differentiation process, we have identified ISG15 as being induced during late erythroid differentiation.
Ana Leticia Maragno +8 more
doaj +1 more source
Hematology, Transfusion and Cell Therapy, 2023 Due to the challenges associated with accessing bone marrow samples from individuals with sickle cell anemia (SCA), hematopoiesis in the context of this disease remains less studied compared to other pathologies.
J Milhomens +6 more
doaj +1 more source
The accumulation of miR-125b-5p is indispensable for efficient erythroblast enucleation
Cell Death and Disease, 2022 Erythroblast enucleation is a precisely regulated but not clearly understood process. Polycythemia shows pathological erythroblast enucleation, and we discovered a low miR-125b-5p level in terminal erythroblasts of patients with polycythemia vera (PV ...
Fang Fang +13 more
doaj +1 more source
Haematologica, 2010 Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal ...
openaire +3 more sources
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis
Advanced Science, EarlyView.Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang +16 more
wiley +1 more source
Leishmania donovani infection induces anemia in hamsters by differentially altering erythropoiesis in bone marrow and spleen. [PDF]
PLoS ONE, 2013 Leishmania donovani is a parasite that causes visceral leishmaniasis by infecting and replicating in macrophages of the bone marrow, spleen, and liver. Severe anemia and leucopenia is associated with the disease.
William P Lafuse +7 more
doaj +1 more source