Results 11 to 20 of about 11,797 (185)
Erythroblast Enucleation [PDF]
Stem Cells International, 2011 Even though the production of orthochromatic erythroblasts can be scaled up to fulfill clinical requirements, enucleation remains one of the critical rate-limiting steps in the production of transfusable red blood cells. Mammalian erythrocytes extrude their nucleus prior to entering circulation, likely to impart flexibility and improve the ability to ...
Ganesan Keerthivasan +2 more
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This is not an erythroblast [PDF]
Blood, 2015 ![Figure][1] An 82-year-old woman was admitted for diffuse bone pain and deep asthenia. She was receiving erythropoietin for a refractory cytopenia with ring sideroblasts and thrombocytosis diagnosed 14 years before.
Adriana, Plesa, Pierre, Sujobert
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TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Медицинская иммунология, 2023 In recent years, research has revealed a wide variety of erythroid cell functions, including modulation of innate and adaptive immune responses. Anemic or hypoxic stress stimulates a physiological response in the form of stress erythropoiesis, aimed at ...
Yu. A. Shevchenko +2 more
doaj +1 more source
Antitumor properties of nuclear erythroid cells
Сибирский онкологический журнал, 2022 Purpose. To study suppressor and/or cytotoxic activity of the nuclear erythroid cells (NEC) against tumor cells of various origins. Material and Methods. C57Bl/6 mice and P815, L1210, B16 and L929 tumor cells were used.
V. A. Kozlov +4 more
doaj +1 more source
Estimating biological reference intervals for cell blood counts in a dog population
Revista Colombiana de Ciencias Pecuarias, 2020 Background: The results from automated equipment and peripheral blood smears allow correlating clinical data with cellular blood counts (CBC), generating information on pathologies of hematological and non-hematological origin in dogs.
Valentina Ochoa-Ruíz +6 more
doaj +1 more source
Scientific Reports, 2022 β-Thalassaemia results from defects in β-globin chain production, leading to ineffective erythropoiesis and subsequently to severe anaemia and other complications.
Pornthip Chaichompoo +9 more
doaj +1 more source
The oxygen dissociation curve of blood in COVID-19–An update
Frontiers in Medicine, 2023 An impressive effect of the infection with SARS-Co-19 is the impairment of oxygen uptake due to lung injury. The reduced oxygen diffusion may potentially be counteracted by an increase in oxygen affinity of hemoglobin.
Dieter Böning +3 more
doaj +1 more source
Purification of erythroblastic nests [PDF]
Blood, 1981 We describe a method for preparing purified erythroblastic nests in large numbers (approximately 10(6)/run) in three steps: (1) induction of splenic erythropoiesis in mice, (2) preparative differential centrifugation for the removal of erythrocytes and single cells from spleen cell suspensions, and (3) sedimentation in an isokinetic gradient of Ficoll ...
A J, Macario +3 more
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Haematologica, 2020 Erythropoiesis is one of the most efficient cellular processes in the human body producing approximately 2.5 million red blood cells every second.
Lea A. Hampton-O’Neil +5 more
doaj +1 more source