Results 11 to 20 of about 23,516 (234)
STAR Protocols, 2022 Summary: This protocol describes the generation and characterization of human induced pluripotent stem cells (hiPSCs) from erythroblasts. A key difference with classical protocols is the reprogramming of erythroblasts from a simple blood draw as opposed ...
Sylvain Perriot +3 more
doaj +3 more sources
Scientific Reports, 2017 Hematopoietic ontogeny is characterized by distinct primitive and definitive erythroid lineages. Definitive erythroblasts mature and enucleate extravascularly and form a unique membrane skeleton, composed of spectrin, 4.1R-complex, and ankyrinR-complex ...
Yu-Shan Huang +10 more
doaj +3 more sources
Ephrin/Eph receptor interaction facilitates macrophage recognition of differentiating human erythroblasts [PDF]
Haematologica, 2020 Erythropoiesis is one of the most efficient cellular processes in the human body producing approximately 2.5 million red blood cells every second.
Lea A. Hampton-O’Neil +5 more
doaj +3 more sources
Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts. [PDF]
PLoS ONE, 2016 In human adult erythroid cells, lower than normal levels of Krüppel-like transcription factor 1 (KLF1) are generally associated with decreased adult β- and increased fetal γ-globin gene expression. KLF1 also regulates BCL11A, a known repressor of adult γ-
Divya S Vinjamur +5 more
doaj +2 more sources
CD8+ T cell activation by murine erythroblasts infected with malaria parasites [PDF]
Scientific Reports, 2013 Recent studies show that some human malaria parasite species Plasmodium falciparum and P.vivax parasitize erythroblasts; however, the biological and clinical significance of this is unclear. To investigate further, we generated a rodent malaria parasite (
T. Imai +8 more
semanticscholar +2 more sources
Intracellular iron and heme trafficking and metabolism in developing erythroblasts
Metallomics, 2017 Vertebrate red blood cells (RBCs) arise from erythroblasts in the human bone marrow through a process known as erythropoiesis. Iron uptake is a crucial hallmark, essential for heme biosynthesis in the differentiating erythroblasts, which are dedicated to
M. Kafina, B. Paw
semanticscholar +2 more sources
Grab regulates transferrin receptor recycling and iron uptake in developing erythroblasts.
Blood, 2022 Developing erythroblasts acquire massive amounts of iron through the transferrin (Tf) cycle, which involves endocytosis, sorting, and recycling of the Tf-Tf receptor (Tfrc) complex.
Mengying Chen +9 more
semanticscholar +1 more source
Expansion and differentiation of ex vivo cultured erythroblasts in scalable stirred bioreactors
bioRxiv, 2022 Transfusion of donor-derived red blood cells (RBCs) is the most common form of cell therapy. Production of transfusion-ready cultured RBCs (cRBCs) is a promising replacement for the current fully donor-dependent therapy.
Joan Sebastián Gallego-Murillo +5 more
semanticscholar +1 more source
British Journal of Haematology, 2021 Adult erythropoiesis entails a series of well‐coordinated events that produce mature red blood cells. One of such events is the mitochondria clearance that occurs cell‐autonomously via autophagy‐dependent mechanisms.
Chong Yang +6 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2021 Bioreactors are increasingly implemented for large scale cultures of various mammalian cells, which requires optimization of culture conditions. Such upscaling is also required to produce red blood cells (RBC) for transfusion and therapy purposes ...
Francesca Aglialoro +7 more
semanticscholar +1 more source