Results 61 to 70 of about 393,416 (146)

The role of the reticulocyte-binding-like protein homologues of Plasmodium in erythrocyte sensing and invasion

, 2012
Malaria remains a serious public health problem with significant morbidity and mortality accounting for nearly 20% of all childhood deaths in Africa.
Yap, Sally Shu Lin, Gunalan, Karthigayan, Preiser, Peter Rainer, Huang, Ximei, Gao, Xiaohong   +4 more
core   +1 more source

Variation in use of erythrocyte invasion pathways by Plasmodium falciparum mediates evasion of human inhibitory antibodies.

, 2008
Antibodies that inhibit Plasmodium falciparum invasion of erythrocytes are believed to be an important component of immunity against malaria. During blood-stage infection, P.
Reiling, L, Janine Stubbs, McCallum, F. J., Beeson, J. G., Kevin Marsh, Fiona J. McCallum, Stubbs, J, Cowman, A. F., Nicole A. Lister, Lister, N. A., Kristina E.M. Persson, Lister, NA, Beeson, JG, Persson, KEM, Linda Reiling, McCallum, FJ, Marsh, K, Cowman, AF, Alan F. Cowman, Reiling, L., Marsh, K., Persson, Kristina,, Stubbs, J., James G. Beeson, Lund University.   +24 more
core   +1 more source

The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion

eLife, 2020
Red blood cell (RBC) invasion by malaria merozoites involves formation of a parasitophorous vacuole into which the parasite moves. The vacuole membrane seals and pinches off behind the parasite through an unknown mechanism, enclosing the parasite within ...
Christine R Collins, Fiona Hackett, Steven A Howell, Ambrosius P Snijders, Matthew RG Russell, Lucy M Collinson, Michael J Blackman   +6 more
doaj   +1 more source

Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies.

, 2014
Invasion of host erythrocytes is essential to the life cycle of Plasmodium parasites and development of the pathology of malaria. The stages of erythrocyte invasion, including initial contact, apical reorientation, junction formation, and active ...
Jonathan Bartlett, Alexander D. Douglas, Kathryn A. Hjerrild, Willem A. de Jongh, Rebecca Ashfield, Jing Jin, Stine B. Clemmensen, Joseph J. Illingworth, Katherine E. Wright, Simon J. Draper, Matthew K. Higgins, Rebecca E. Brown   +11 more
core   +1 more source

Malaria Species And Southeast Asian Ovalocytosis Defined By A 27-BP Deletion In The Erythrocyte Band 3 Gene [PDF]

, 2002
To evaluate the resistance of SAO against species specific malaria infection, relationships between parasite species and the 27-bp deletion in the band 3 gene were studied in malaria endemic Sumba Island, eastern Indonesia.
Soemantri, Augustinus, Ishida, Takafumi, Kimura, Masako   +2 more
core   +2 more sources

Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites.

PLoS Pathogens, 2017
Proteases have been implicated in a variety of developmental processes during the malaria parasite lifecycle. In particular, invasion and egress of the parasite from the infected hepatocyte and erythrocyte, critically depend on protease activity ...
Christine S Hopp, Brandy L Bennett, Satish Mishra, Christine Lehmann, Kirsten K Hanson, Jing-Wen Lin, Kimberly Rousseau, Filomena A Carvalho, Wouter A van der Linden, Nuno C Santos, Matthew Bogyo, Shahid M Khan, Volker Heussler, Photini Sinnis   +13 more
doaj   +1 more source

Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery.

PLoS Biology, 2019
Cyclic AMP (cAMP) is an important signalling molecule across evolution, but its role in malaria parasites is poorly understood. We have investigated the role of cAMP in asexual blood stage development of Plasmodium falciparum through conditional ...
Avnish Patel, Abigail J Perrin, Helen R Flynn, Claudine Bisson, Chrislaine Withers-Martinez, Moritz Treeck, Christian Flueck, Giuseppe Nicastro, Stephen R Martin, Andres Ramos, Tim W Gilberger, Ambrosius P Snijders, Michael J Blackman, David A Baker   +13 more
doaj   +1 more source

The 10 kDa domain of human erythrocyte protein 4.1 binds the Plasmodium falciparum EBA-181 protein

Malaria Journal, 2006
Background Erythrocyte invasion by Plasmodium falciparum parasites represents a key mechanism during malaria pathogenesis. Erythrocyte binding antigen-181 (EBA-181) is an important invasion protein, which mediates a unique host cell entry pathway.
Coetzer Theresa L, Lanzillotti Roberto
doaj   +1 more source

Disrupting CD147-RAP2 interaction abrogates erythrocyte invasion by Plasmodium falciparum

, 2018
Key PointsThe CD147-RAP2 interaction is essential for erythrocyte invasion by P falciparum and is independent from the known interactions involved.
Bin Wang, Ruo Chen, Ping Zhu, Zhao Zhang, Meng-Yao Zhang, Xiao-Dong Wu, Gang Nan, Jiao Wu, Kun Zhang, Yang Zhang, Fei Feng, Zhi-Nan Chen, Ding Wei, Wan Huang, Hui-Jie Bian, Peng Lin, Min-Min Qin   +16 more
core   +1 more source

Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes.

PLoS Pathogens, 2015
The most severe form of malaria in humans is caused by the protozoan parasite Plasmodium falciparum. The invasive form of malaria parasites is termed a merozoite and it employs an array of parasite proteins that bind to the host cell to mediate invasion.
Wai-Hong Tham, Nicholas T Y Lim, Greta E Weiss, Sash Lopaticki, Brendan R E Ansell, Megan Bird, Isabelle Lucet, Dominique Dorin-Semblat, Christian Doerig, Paul R Gilson, Brendan S Crabb, Alan F Cowman   +11 more
doaj   +1 more source