Results 51 to 60 of about 393,416 (146)

Erythrocyte invasion receptors for Plasmodium falciparum: new and old [PDF]

Transfusion Medicine, 2016
SUMMARYUnderstanding the complex process by which the invasive form of the Plasmodium falciparum parasite, the merozoite, attaches to and invades erythrocytes as part of its blood stage life cycle represents a key area of research in the battle to combat malaria.
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INFLUENCE OF ERYTHROCYTE MEMBRANE COMPONENTS ON MALARIA MEROZOITE INVASION [PDF]

The Journal of Experimental Medicine, 1973
Chymotrypsin- and Pronase-treated human erythrocytes were refractory to invasion by P. knowlesi merozoites; invasion was not inhibited by trypsin or neurammidase treatment. These data implicate a surface protein other than sialoglycoprotein as the receptor site for merozoites.
L H, Miller, J A, Dvorak, T, Shiroishi, J R, Durocher   +3 more
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Plasmodium falciparum proteinases: cloning of the putative gene coding for the merozoite proteinase for erythrocyte invasion (MPEI) and determination of hydrolysis sites of spectrin by Pf37 proteinase

Memorias do Instituto Oswaldo Cruz, 1994
Numerous proteinase activities have been shown to be essential for the survival of Plasmodium falciparum. One approach to antimalarial chemotherapy, would be to block specifically one or several of these activities, by using compounds structurally ...
I. Florent, S. Le Bonniec, B. Carcy, P. Grellier, O. Mercereau-Puijalon, S. Bonnefoy, D. Dhermy, M. Monsigny, R. Mayer, J. Schrével   +9 more
doaj   +1 more source

Attempts to block the MTRAP-Semaphorin-7A interaction has no effect on erythrocyte invasion.

, 2012
(A) Recombinant Semaphorin-7A and MTRAP have no inhibitory effect on erythrocyte invasion. Purified pentamerised Semaphorin-7A or MTRAP were added to P.
Susan Lea (121195), Cecile Crosnier (121193), Gavin J. Wright (121201), Leyla Y. Bustamante (121191), S. Josefin Bartholdson (121189), Steven Johnson (41082), Julian C. Rayner (121198)   +6 more
core   +1 more source

An analytical model describing the mechanics of erythrocyte membrane wrapping during active invasion of a plasmodium falciparum merozoite

, 2023
The invasion of a merozoite into an erythrocyte by membrane wrapping is a hallmark of malaria pathogenesis. The invasion involves biomechanical interactions whereby the merozoite exerts actomyosin-based forces to push itself into and through the ...
Thomas Franz, Tamer Abdalrahman, Chimwemwe Msosa, Msosa, Chimwemwe, Abdalrahman, Tamer, Franz, Thomas   +5 more
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The Plasmodium berghei merozoite protein PbGAC is critically involved in erythrocyte binding during invasion

Parasites & Vectors
Background The invasion of Plasmodium merozoites into host erythrocytes is initiated through specific ligand–receptor interactions. This interaction results in subsequent invasion events, facilitated by the formation of a moving junction via AMA-1 and ...
Junying Gao, Ning Jiang, Yiwei Zhang, Ran Chen, Ying Feng, Xiaoyu Sang, Qijun Chen   +6 more
doaj   +1 more source

Structural organization of erythrocyte membrane microdomains and their relation with malaria susceptibility

Communications Biology, 2021
Olivieri et al. exploit floating properties of microdomain-associated proteins to investigate host proteins important for Plasmodium falciparum erythrocyte invasion. Using proteomic and bioinformatic approaches, they analyze clusters of protein abundance
Anna Olivieri, Rebecca S. Lee, Federica Fratini, Cyrianne Keutcha, Mudit Chaand, Valentina Mangano, Francesco Celani, Stefania Mochi, Cecilia Birago, Silvio Paone, Felicia Grasso, Valentina Tirelli, Mario Falchi, Estela Shabani, Stefania Bertoncini, Bienvenu Sodiomon Sirima, Elisabetta Pizzi, David Modiano, Manoj T. Duraisingh, Marta Ponzi   +19 more
doaj   +1 more source

Erythrocyte invasion phenotypes of Plasmodium falciparum in The Gambia.

, 2003
In vitro experimentation with Plasmodium falciparum has determined that a number of different receptor-ligand interactions are involved in the invasion of erythrocytes.
Conway, David J, Baum, Jake, Pinder, Margaret   +2 more
core   +1 more source

Dynamic hinge-motion of PfRIPR revealed by malaria invasion inhibitory antibodies

Nature Communications
The PfPCRCR complex is essential for invasion of human erythrocytes by the deadliest malaria parasite, Plasmodium falciparum. Antibodies against each subunit of PfPCRCR prevent erythrocyte invasion and the PfRH5 component is currently the most advanced ...
Brendan Farrell, Andrew J. R. Cooper, Egle Butkeviciute, Lawrence T. Wang, Emily Egerton-Warburton, Joshua Tan, Matthew K. Higgins   +6 more
doaj   +1 more source

Invasion of erythrocytes by Plasmodium falciparum in vitro

Parasitology, 1975
The erythrocytic stages of Plasmodium falciparum from Aotus trivirgatus were grown in Mill Hill medium. Significant invasion of erythrocytes was obtained by a subculture technique. This invasion, by parasites grown in Aotus erythrocytes, was greater when human erythrocytes were added to the cultures than when parasites were allowed to invade Aotus ...
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