Results 31 to 40 of about 22,553 (250)

Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites. [PDF]

PLoS Pathogens, 2010
The invasion of erythrocytes by Plasmodium merozoites requires specific interactions between host receptors and parasite ligands. Parasite proteins that bind erythrocyte receptors during invasion are localized in apical organelles called micronemes and ...
Shailja Singh, M Mahmood Alam, Ipsita Pal-Bhowmick, Joseph A Brzostowski, Chetan E Chitnis   +4 more
doaj   +1 more source

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion

eLife, 2017
The most lethal form of malaria in humans is caused by Plasmodium falciparum. These parasites invade erythrocytes, a complex process involving multiple ligand-receptor interactions.
Xavier Sisquella, Thomas Nebl, Jennifer K Thompson, Lachlan Whitehead, Brian M Malpede, Nichole D Salinas, Kelly Rogers, Niraj H Tolia, Andrea Fleig, Joseph O’Neill, Wai-Hong Tham, F David Horgen, Alan F Cowman   +12 more
doaj   +1 more source

Invasion and Persistent Intracellular Colonization of Erythrocytes [PDF]

The Journal of Experimental Medicine, 2001
The expanding genus Bartonella includes zoonotic and human-specific pathogens that can cause a wide range of clinical manifestations. A productive infection allowing bacterial transmission by blood-sucking arthropods is marked by an intraerythrocytic bacteremia that occurs exclusively in specific human or animal reservoir hosts.
Ralf Schülein, Anja Seubert, Christian Gille, Christa Lanz, Yves Hansmann, Yves Piémont, Christoph Dehio   +6 more
openaire   +1 more source

The Cellular and Molecular Interaction Between Erythrocytes and Plasmodium falciparum Merozoites

Frontiers in Cellular and Infection Microbiology, 2022
Plasmodium falciparum is the most lethal human malaria parasite, partly due to its genetic variability and ability to use multiple invasion routes via its binding to host cell surface receptors.
Jessica Molina-Franky, Jessica Molina-Franky, Jessica Molina-Franky, Manuel Elkin Patarroyo, Manuel Elkin Patarroyo, Manuel Elkin Patarroyo, Markus Kalkum, Manuel Alfonso Patarroyo, Manuel Alfonso Patarroyo, Manuel Alfonso Patarroyo   +9 more
doaj   +1 more source

Bartonella henselaeInvasion of Feline Erythrocytes In Vitro [PDF]

Infection and Immunity, 1998
ABSTRACTBartonella henselae, the causative agent of cat scratch disease, establishes long-term bacteremia in cats, in which it attaches to and invades feline erythrocytes (RBC). Feline RBC invasion was assessed in vitro, based on gentamicin selection for intracellular bacteria or by laser confocal microscopy and digital sectioning.
J R, Mehock, C E, Greene, F C, Gherardini, T W, Hahn, D C, Krause   +4 more
openaire   +2 more sources

Non-invasive measurement of erythrocyte zinc protoporphyrin in children [PDF]

Pediatric Research, 2018
Reliable screening for iron deficiency (ID) has required a blood sample and cost-intensive laboratory measurements. A novel method to non-invasively measure erythrocyte zinc protoporphyrin (ZnPP), an established marker for ID, is evaluated in children.ZnPP was determined non-invasively by fluorescence measurements on the wet vermillion of the lower lip
Christian, Homann, Georg, Hennig, Felicitas, Maier, Herbert, Stepp, Lesca M, Holdt, Michael, Vogeser, Ronald, Sroka, Berthold, Koletzko   +7 more
openaire   +2 more sources

Erythrocyte CD55 mediates the internalization of Plasmodium falciparum parasites

eLife, 2021
Invasion of human erythrocytes by the malaria parasite Plasmodium falciparum is a multi-step process. Previously, a forward genetic screen for P. falciparum host factors identified erythrocyte CD55 as essential for invasion, but its specific role and how
Bikash Shakya, Saurabh D Patel, Yoshihiko Tani, Elizabeth S Egan   +3 more
doaj   +1 more source

Plasmodium falciparum variant STEVOR antigens are expressed in merozoites and possibly associated with erythrocyte invasion

Malaria Journal, 2008
Background Plasmodium falciparum STEVOR proteins, encoded by the multicopy stevor gene family have no known biological functions. Their expression and unique locations in different parasite life cycle stages evoke multiple functionalities.
Petter Michaela, Schreiber Nadine, Bonow Insa, Khattab Ayman, Schmetz Christel, Klinkert Mo-Quen   +5 more
doaj   +1 more source

4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation

Nature Communications, 2021
Here, Geoghegan, Evelyn et al. provide a lattice light-sheet microscopy based 4D imaging pipeline to quantitatively investigate Plasmodium spp. invasion and show that the nascent parasitophorous vacuole is predominantly formed from host’s erythrocyte ...
Niall D. Geoghegan, Cindy Evelyn, Lachlan W. Whitehead, Michal Pasternak, Phoebe McDonald, Tony Triglia, Danushka S. Marapana, Daryan Kempe, Jennifer K. Thompson, Michael J. Mlodzianoski, Julie Healer, Maté Biro, Alan F. Cowman, Kelly L. Rogers   +13 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source