Results 21 to 30 of about 22,553 (250)

Blood donor variability is a modulatory factor for P. falciparum invasion phenotyping assays

Scientific Reports, 2021
Human erythrocytes are indispensable for Plasmodium falciparum development. Unlike other eukaryotic cells, there is no existing erythroid cell line capable of supporting long-term P. falciparum in vitro experiments.
Laty G. Thiam, Prince B. Nyarko, Kwadwo A. Kusi, Makhtar Niang, Yaw Aniweh, Gordon A. Awandare   +5 more
doaj   +1 more source

Characterization of the erythrocyte GTPase Rac1 in relation to Plasmodium falciparum invasion

Scientific Reports, 2020
Malaria is still a devastating disease with 228 million cases globally and 405,000 lethal outcomes in 2018, mainly in children under five years of age. The threat of emerging malaria strains resistant to currently available drugs has made the search for ...
Silvio Paone, Sarah D’Alessandro, Silvia Parapini, Francesco Celani, Valentina Tirelli, Manoochehr Pourshaban, Anna Olivieri   +6 more
doaj   +1 more source

Complement receptor 1 is a sialic acid-independent erythrocyte receptor of Plasmodium falciparum. [PDF]

PLoS Pathogens, 2010
Plasmodium falciparum is a highly lethal malaria parasite of humans. A major portion of its life cycle is dedicated to invading and multiplying inside erythrocytes. The molecular mechanisms of erythrocyte invasion are incompletely understood.
Carmenza Spadafora, Gordon A Awandare, Karen M Kopydlowski, Jozsef Czege, J Kathleen Moch, Robert W Finberg, George C Tsokos, José A Stoute   +7 more
doaj   +1 more source

Plasmodium yoelii Erythrocyte Binding Like Protein Interacts With Basigin, an Erythrocyte Surface Protein

Frontiers in Cellular and Infection Microbiology, 2021
Erythrocyte recognition and invasion is critical for the intra-erythrocytic development of Plasmodium spp. parasites. The multistep invasion process involves specific interactions between parasite ligands and erythrocyte receptors.
Takaaki Yuguchi, Bernard N. Kanoi, Hikaru Nagaoka, Toyokazu Miura, Daisuke Ito, Hiroyuki Takeda, Takafumi Tsuboi, Eizo Takashima, Hitoshi Otsuki   +8 more
doaj   +1 more source

Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites. [PDF]

PLoS Pathogens, 2008
Invasion by the malaria merozoite depends on recognition of specific erythrocyte surface receptors by parasite ligands. Plasmodium falciparum uses multiple ligands, including at least two gene families, reticulocyte binding protein homologues (RBLs) and ...
Xiaohong Gao, Kim Pin Yeo, Siqi Sharon Aw, Claudia Kuss, Jayasree K Iyer, Saraswathy Genesan, Ravikumar Rajamanonmani, Julien Lescar, Zbynek Bozdech, Peter R Preiser   +9 more
doaj   +1 more source

Invasion by P. falciparum merozoites suggests a hierarchy of molecular interactions. [PDF]

PLoS Pathogens, 2005
Central to the pathology of malaria disease are the repeated cycles of parasite invasion and destruction of human erythrocytes. In Plasmodium falciparum, the most virulent species causing malaria, erythrocyte invasion involves several specific receptor ...
Jake Baum, Alexander G Maier, Robert T Good, Ken M Simpson, Alan F Cowman   +4 more
doaj   +2 more sources

The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection

Malaria Journal, 2019
Background Malaria disease commences when blood-stage parasites, called merozoites, invade human erythrocytes. Whilst the process of invasion is traditionally seen as being entirely merozoite-driven, emerging data suggests erythrocyte biophysical ...
Marion Koch, Jaimini Cegla, Ben Jones, Yuning Lu, Ziad Mallat, Andrew M. Blagborough, Fiona Angrisano, Jake Baum   +7 more
doaj   +1 more source

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

eLife, 2014
Plasmodium falciparum causes the most severe form of malaria in humans and is responsible for over 700,000 deaths annually. It is an obligate intracellular parasite and invades erythrocytes where it grows in a relatively protected niche.
Lin Chen, Yibin Xu, Julie Healer, Jenny K Thompson, Brian J Smith, Michael C Lawrence, Alan F Cowman   +6 more
doaj   +1 more source

Recent increase in low complexity polygenomic infections and sialic acid-independent invasion pathways in Plasmodium falciparum from Western Gambia

Parasites & Vectors, 2023
Background The malaria parasite Plasmodium falciparum utilizes multiple alternative receptor-ligand interactions for the invasion of human erythrocytes. While some P.
Nora Nghochuzie Nganyewo, Fatoumata Bojang, Eniyou Cheryll Oriero, Ndey Fatou Drammeh, Olumide Ajibola, Haddijatou Mbye, Aminata Seedy Jawara, Simon Corea, Gordon Akanzuwine Awandare, Umberto D’Alessandro, Lucas N. Amenga-Etego, Alfred Amambua-Ngwa   +11 more
doaj   +1 more source

Cysteine Residues in Region 6 of the Plasmodium yoelii Erythrocyte-Binding-like Ligand That Are Related to Its Localization and the Course of Infection

Biomolecules, 2023
Plasmodium malaria parasites use erythrocyte-binding-like (EBL) ligands to invade erythrocytes in their vertebrate host. EBLs are released from micronemes, which are secretory organelles located at the merozoite apical end and bind to erythrocyte surface
Hitoshi Otsuki, Osamu Kaneko, Daisuke Ito, Yoko Kondo, Hideyuki Iriko, Tomoko Ishino, Mayumi Tachibana, Takafumi Tsuboi, Motomi Torii   +8 more
doaj   +1 more source