RBC barcoding allows for the study of erythrocyte population dynamics and P. falciparum merozoite invasion. [PDF]
PLoS ONE, 2014 Plasmodium falciparum invasion of host erythrocytes is essential for the propagation of the blood stage of malaria infection. Additionally, the brief extracellular merozoite stage of P.
Martha A Clark +5 more
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Identification and characterization of a novel Plasmodium falciparum adhesin involved in erythrocyte invasion. [PDF]
PLoS ONE, 2013 Malaria remains a major health problem worldwide. All clinical symptoms of malaria are attributed to the asexual blood stages of the parasite life cycle. Proteins resident in apical organelles and present on the surface of P.
Nidhi Hans +5 more
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Plasmodium falciparum reticulocyte binding-like homologue protein 2 (PfRH2) is a key adhesive molecule involved in erythrocyte invasion. [PDF]
PLoS ONE, 2011 Erythrocyte invasion by Plasmodium merozoites is a complex, multistep process that is mediated by a number of parasite ligand-erythrocyte receptor interactions. One such family of parasite ligands includes the P. falciparum reticulocyte binding homologue
Tajali Sahar +6 more
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Rodent Malaria Erythrocyte Preference Assessment by an Ex Vivo Tropism Assay
Frontiers in Cellular and Infection Microbiology, 2021 Circulating red blood cells consist of young erythrocytes (early and late reticulocytes) and mature erythrocytes (normocytes). The human malaria parasites, Plasmodium falciparum and P.
Yew Wai Leong +8 more
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Erythrocyte tropism of malarial parasites: The reticulocyte appeal
Frontiers in Microbiology, 2022 Erythrocytes are formed from the enucleation of erythroblasts in the bone marrow, and as erythrocytes develop from immature reticulocytes into mature normocytes, they undergo extensive cellular changes through their passage in the blood. During the blood
Yew Wai Leong +6 more
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Blood donor variability is a modulatory factor for P. falciparum invasion phenotyping assays
Scientific Reports, 2021 Human erythrocytes are indispensable for Plasmodium falciparum development. Unlike other eukaryotic cells, there is no existing erythroid cell line capable of supporting long-term P. falciparum in vitro experiments.
Laty G. Thiam +5 more
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Frontiers in Cellular and Infection Microbiology, 2023 Plasmodium species cause malaria, and in the instance of Plasmodium falciparum is responsible for a societal burden of over 600,000 deaths annually. The symptoms and pathology of malaria are due to intraerythocytic parasites.
Daisuke Ito +6 more
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Characterization of the erythrocyte GTPase Rac1 in relation to Plasmodium falciparum invasion
Scientific Reports, 2020 Malaria is still a devastating disease with 228 million cases globally and 405,000 lethal outcomes in 2018, mainly in children under five years of age. The threat of emerging malaria strains resistant to currently available drugs has made the search for ...
Silvio Paone +6 more
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Frontiers in Cellular and Infection Microbiology, 2021 Erythrocyte recognition and invasion is critical for the intra-erythrocytic development of Plasmodium spp. parasites. The multistep invasion process involves specific interactions between parasite ligands and erythrocyte receptors.
Takaaki Yuguchi +8 more
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Complement receptor 1 is a sialic acid-independent erythrocyte receptor of Plasmodium falciparum. [PDF]
PLoS Pathogens, 2010 Plasmodium falciparum is a highly lethal malaria parasite of humans. A major portion of its life cycle is dedicated to invading and multiplying inside erythrocytes. The molecular mechanisms of erythrocyte invasion are incompletely understood.
Carmenza Spadafora +7 more
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