The Molecular Basis of Erythrocyte Invasion by Malaria Parasites [PDF]
Cell Host and Microbe, 2017 Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of immunologically privileged erythrocytes provides a relatively protective niche as well as access to a rich source of nutrients. Plasmodium spp. target erythrocytes of different ages, but share a common mechanism of invasion. Specific engagement of erythrocyte receptors
Alan F Cowman +2 more
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The Role and Mechanism of Erythrocyte Invasion by Francisella tularensis [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 Francisella tularensis is an extremely virulent bacterium that can be transmitted naturally by blood sucking arthropods. During mammalian infection, F. tularensis infects numerous types of host cells, including erythrocytes.
Deanna M. Schmitt +16 more
doaj +6 more sources
Roles of the RON3 C-terminal fragment in erythrocyte invasion and blood-stage parasite proliferation in Plasmodium falciparum [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Plasmodium species cause malaria, and in the instance of Plasmodium falciparum is responsible for a societal burden of over 600,000 deaths annually. The symptoms and pathology of malaria are due to intraerythocytic parasites.
Daisuke Ito +6 more
doaj +2 more sources
PdpC, a secreted effector protein of the type six secretion system, is required for erythrocyte invasion by Francisella tularensis LVS [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Francisella tularensis is a gram negative, intracellular pathogen that is the causative agent of the potentially fatal disease, tularemia. During infection, F. tularensis is engulfed by and replicates within host macrophages. Additionally, this bacterium
Stuart Cantlay +2 more
doaj +2 more sources
Host-pathogen interactions involved in erythrocyte invasion by Francisella tularensis [PDF]
Frontiers in Cellular and Infection MicrobiologyFrancisella tularensis is a gram negative, facultative intracellular bacterium that causes the zoonotic disease tularemia. F. tularensis is capable of invading mammalian erythrocytes, a phenomenon that enhances colonization of ticks following a blood ...
Rori M. Schreiber +6 more
doaj +2 more sources
Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake [PDF]
eLife, 2021 Malaria parasites use the RhopH complex for erythrocyte invasion and channel-mediated nutrient uptake. As the member proteins are unique to Plasmodium spp., how they interact and traffic through subcellular sites to serve these essential functions is ...
Marc A Schureck +11 more
doaj +2 more sources
An ApiAP2 Family Transcriptional Factor PfAP2-06B Regulates Erythrocyte Invasion Indirectly in Plasmodium falciparum [PDF]
PathogensObligate intracellular parasites must efficiently invade host cells to complete their life cycle and facilitate transmission. For the malaria-causing parasite Plasmodium falciparum, the invasion of an erythrocyte is a critical process, and thereby a key ...
Qiyang Shi +8 more
doaj +2 more sources
Plasmodium falciparum exploits CD44 as a coreceptor for erythrocyte invasion.
Blood, 2023 Abstract The malaria parasite Plasmodium falciparum invades and replicates asexually within human erythrocytes. CD44 expressed on erythrocytes was previously identified as an important host factor for P falciparum infection through a forward genetic screen, but little is known about its regulation or function in these cells, nor how it ...
Baro B +8 more
europepmc +3 more sources
Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum [PDF]
Nature, 2011 Erythrocyte invasion by Plasmodium falciparum is central to the pathogenesis of malaria. Invasion requires a series of extracellular recognition events between erythrocyte receptors and ligands on the merozoite, the invasive form of the parasite.
Leyla Y Bustamante +2 more
exaly +3 more sources
Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA [PDF]
eLife, 2017 Plasmodium falciparum causes malaria in humans with over 450,000 deaths annually. The asexual blood stage involves invasion of erythrocytes by merozoites, in which they grow and divide to release daughter merozoites, which in turn invade new erythrocytes
Lin Chen +7 more
doaj +2 more sources