Results 121 to 130 of about 79,234 (272)

Is Deuterium Sequestering by Reactive Carbon Atoms an Important Mechanism to Reduce Deuterium Content in Biological Water?

FASEB BioAdvances, EarlyView.
Deuterium, a heavy isotope of hydrogen, is universal in nature, but it disrupts the mitochondrial ATPase pumps. One mechanism that biological organisms may use to reduce deuterium levels in the mitochondria is to sequester deuterium bound to carbon atoms in a small set of organic molecules that have a unique configuration to support such trapping ...
Stephanie Seneff, Greg Nigh, Anthony M. Kyriakopoulos   +2 more
wiley   +1 more source

Heme metabolism genes Downregulated in COPD Cachexia. [PDF]

, 2020
IntroductionCachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes.
Agusti, Alvar, Arora, Itika, Bhatt, Surya P, Casaburi, Richard, Castaldi, Peter J, Dransfield, Mark T, Hersh, Craig P, Kumar, Preeti L, Lee, Sool, Lomas, David A, McDonald, Merry-Lynn N, Morrow, Jarrett D, Parker, Margaret M, Rennard, Stephen I, Silverman, Edwin K, Tal-Singer, Ruth, Thannickal, Victor J, Tiwari, Hemant K, Washko, George, Wells, J Michael, Wilson, Ava C, Wouters, Emiel FM   +21 more
core   +1 more source

Free Foetal Haemoglobin in Severe Early‐Onset Foetal Growth Restriction: A Prospective Multi‐Centre Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To assess foetal circulating free foetal haemoglobin (fHbF) levels and heme defences, correlated to foetal circulatory biometry and foetal sex in severe early‐onset foetal growth restriction (FGR). Design, Setting and Population A prospective study severe early‐onset foetal growth restriction pregnancies with close clinical ...
Adam Brook, Georgia Baynes, Jonathan Scargill, Angelos Evangelinos, Charlotte Brennan‐Richardson, Freya Dow, Yuval Ginsberg, Tal Weissbach, Jana Brodszki, Eva Hansson, Anke Diemert, Kurt Hecher, Katarzyna Maksym, Neil Marlow, Rebecca N. Spencer, Anna L. David, Stefan R. Hansson, Paul Brownbill   +17 more
wiley   +1 more source

The maturation of reticulocytes. I. Following introduction of reticulocytes into polycythemic and normocythemic animals [PDF]

, 1975
Investigations were conducted on the life-span of "stress" reticulocytes and the fate of the early denucleated large-sized reticulocytes in circulating blood.
Shimada, Atsuko
core   +1 more source

Incorporating familial risk, lifestyle factors, and pharmacogenomic insights into personalized noncommunicable disease (NCD) reports for healthcare funder beneficiaries participating in the Open Genome Project

Annals of Human Genetics, EarlyView.
Abstract Introduction An ethics‐guided decision‐making framework was developed for applying pathology‐supported genetic testing, a multifaceted pharmacodiagnostic approach that translates population risk stratification into clinical utility. We introduce this service, supported by the Open Genome Project, which aligns with the beneficence principle in ...
Manie De Klerk, Nicole Van Der Merwe, Johny Erasmus, Lindiwe Whati, Kelebogile E. Moremi, Daniel W. Olivier, Maritha J. Kotze   +6 more
wiley   +1 more source

Biotech drugs : biological therapeutic agents [PDF]

, 2009
The recent years has seen significant growth in a new therapeutic approach to the management of disease. Biological therapeutic agents, constitute a broad category of drugs, usually generated by recombinant techniques from living organisms.
Fenech, Anthony G., Grech, Godfrey
core   +2 more sources

Erythropoiesis, erythropoietin, and iron [PDF]

Blood, 1982
Abstract The basic components of erythropoiesis are stem cell precursors, their stimulation by erythropoietin, and an adequate supply of iron from which to make hemoglobin. This article discusses the effects of each of these and the simple tests by which they may be evaluated clinically.
openaire   +4 more sources

Dual Inhibition of Mast Cells and Thymic Stromal Lymphopoietin Using a Novel Bispecific Antibody, CDX‐622

Allergy, EarlyView.
SCF and TSLP expression are known to drive unique immune responses leading to the onset of allergic and inflammatory diseases. Here, we describe the characterization of a novel bsAb, CDX‐622, that targets SCF and TSLP. CDX‐622 inhibits MC functions through SCF starvation and Type 2 inflammatory responses via TSLP inhibition.
Michael B. Murphy, Laura Vitale, Thomas O'Neill, Deena M. Maurer, Linda Malenchek, Andrea Crocker, Colleen Patterson, Laura Mills‐Chen, Virginia Saley, Nicole M. Antczak, James M. Boyer, Kelly M. McManus, Noe Rico Montanari, Russell A. Hammond, Joel Goldstein, Lawrence J. Thomas, Tibor Keler, Diego Alvarado   +17 more
wiley   +1 more source

Cardiovascular safety of testosterone therapy—Insights from the TRAVERSE trial and beyond: A position statement of the European Expert Panel for Testosterone Research

Andrology, EarlyView.
Abstract Introduction Testosterone therapy has become a cornerstone treatment for men with hypogonadism, offering significant benefits such as improved sexual function, mood, muscle mass, and bone density. However, concerns about its cardiovascular safety have historically tempered its use.
Michael Zitzmann, Giulia Rastrelli, Robert D Murray, David Edwards, Yacov Reisman, Preethi Mohan Rao, Alexander Sahi, Thomas Hugh Jones, Alberto Ferlin, Eleni Armeni, Emiliano Corpas, Jann‐Frederik Cremers, Janine David, Stefan Arver, Leen Antonio, Giovanni Corona   +15 more
wiley   +1 more source

Hematopoietic Cytokine Gene Duplication in Zebrafish Erythroid and Myeloid Lineages

Frontiers in Cell and Developmental Biology, 2018
Hematopoiesis is a precisely orchestrated process regulated by the activity of hematopoietic cytokines and their respective receptors. Due to an extra round of whole genome duplication during vertebrate evolution in teleost fish, zebrafish have two ...
Jana Oltova, Ondrej Svoboda, Ondrej Svoboda, Petr Bartunek   +3 more
doaj   +1 more source