Results 121 to 130 of about 121,038 (379)

NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms

Haematologica, 2019
Ncoa4 mediates autophagic degradation of ferritin, the cytosolic iron storage complex, to maintain intracellular iron homeostasis. Recent evidence also supports a role for Ncoa4 in systemic iron homeostasis and erythropoiesis.
Naiara Santana-Codina, Sebastian Gableske, Maria Quiles Del Rey, B. Małachowska, Mark P. Jedrychowski, Douglas E Biancur, Paul J. Schmidt, Mark D. Fleming, W. Fendler, J. W. Harper, Alec C. Kimmelman, J. Mancias   +11 more
semanticscholar   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

A unique role for Stat5 in recovery from acute anemia [PDF]

, 2006
The precise role of erythropoietin receptor–activated (EpoR-activated) Stat5 in the regulation of erythropoiesis remains unclear. In this issue of the JCI, Menon and colleagues present new experimental data that indicate a distinct role for Stat5 in the ...
Longmore, Gregory D.
core   +3 more sources

Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche.

Blood Advances, 2019
Anemic stress induces the proliferation of stress erythroid progenitors in the murine spleen that subsequently differentiate to generate erythrocytes to maintain homeostasis. This process relies on the interaction between stress erythroid progenitors and
Siyang Hao, J. Xiang, Dai-Chen Wu, James W. Fraser, Baiye Ruan, Jingwei Cai, A. Patterson, Z. Lai, R. Paulson   +8 more
semanticscholar   +1 more source

Anaemia in patients with heart failure and mildly reduced or preserved ejection fraction: A prespecified analysis of the FINEARTS‐HF trial

European Journal of Heart Failure, EarlyView.
ABSTRACT Aims Anaemia is common in heart failure with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) and associated with poor clinical outcomes. While renin–angiotensin system blockers reduce haemoglobin, little is known about the effect of mineralocorticoid receptor antagonists on haemoglobin and in patients with anaemia.
Misato Chimura, Mingming Yang, Alasdair D. Henderson, Pardeep S. Jhund, Kieran F. Docherty, Brian L. Claggett, Akshay S. Desai, Gerasimos Filippatos, Grzegorz Gajos, Katharina Mueller, Andrea Glasauer, Katja Rohwedder, Prabhakar Viswanathan, Carolyn S.P. Lam, Naoki Sato, Michele Senni, Adriaan A. Voors, Faiez Zannad, Mehmet B. Yilmaz, Bertram Pitt, Muthiah Vaduganathan, Scott D. Solomon, John J.V. McMurray, on behalf of the FINEARTS‐HF Committees and Investigators   +23 more
wiley   +1 more source

Advances in the generation of erythrocytes from stem cells in vitro

Hematology
Red blood cell transfusion is the main treatment to improve anemia caused by many reasons and has important clinical application value. However, the supply of red blood cells at home and abroad is currently very tight.
Yating Ling, Hailin Du, Yu Zhang, Qiang Fu, Chengtao He   +4 more
doaj   +1 more source

Intravascular Large B-Cell Lymphoma Presenting as Dementia and Hemolytic Anemia [PDF]

, 2010
Background: Intravascular lymphoma (IVL) is an uncommon disease characterized by atypical lymphoid cells growing inside the lumina of small vessels. The diversity of clinical presentation due to possible involvement of multiple organs often complicates ...
Ahle, Guido, Baraniskin, Alexander, Jähnert, Andreas, Kretzschmar, Hans, Schmiegel, Wolff, Schroers, Roland, Theile, Anja   +6 more
core   +1 more source

Lobe specificity of iron-binding to transferrin modulates murine erythropoiesis and iron homeostasis.

Blood, 2019
Transferrin, the major plasma iron binding molecule, interacts with cell surface receptors to deliver iron, modulate hepcidin expression, and regulate erythropoiesis. Transferrin binds and releases iron via either or both of two homologous lobes (N and C)
N. Parrow, Yihang Li, M. Feola, A. Guerra, C. Casu, Princy Prasad, Luke Mammen, Faris Ali, Edvinas Vaicikauskas, S. Rivella, Y. Ginzburg, R. Fleming   +11 more
semanticscholar   +1 more source

Intravenous ferric carboxymaltose in heart failure with iron deficiency (FAIR‐HF2 DZHK05 trial): Sex‐specific outcomes

European Journal of Heart Failure, EarlyView.
Abstract Aims Intravenous iron has emerged as a guideline‐recommended therapy in patients with heart failure and iron deficiency, but the potential sex‐related differences in efficacy are unknown. We aimed to assess sex‐specific outcomes in the Intravenous Iron in Patients with Systolic Heart Failure and Iron Deficiency to Improve Morbidity & Mortality
Mahir Karakas, Tim Friede, Javed Butler, Khawaja M. Talha, Marius Placzek, Thomas Asendorf, Monika Diek, Anna Nosko, Adriane Stas, Stefan Kluge, Dominik Jarczak, Geraldine DeHeer, Meike Rybczynski, Antoni Bayes‐Genis, Michael Böhm, Andrew J.S. Coats, Frank Edelmann, Gerasimos Filippatos, Gerd Hasenfuß, Wilhelm Haverkamp, Mitja Lainscak, Ulf Landmesser, Iain C. Macdougall, Bela Merkely, Burkert M. Pieske, Fausto J Pinto, Tienush Rassaf, Jennifer K. Visser‐Rogers, Giuseppe Rosano, Maurizio Volterrani, Stephan von Haehling, Markus S. Anker, Wolfram Doehner, Hüseyin Ince, Friedrich Koehler, Gianluigi Savarese, Muhammad Shahzeb Khan, Ursula Rauch Kröhnert, Tommaso Gori, Teresa Trenkwalder, Ibrahim Akin, Christina Paitazoglou, Iwona Kobielusz‐Gembala, Luca Kuthi, Norbert Frey, Manuela Licka, Stefan Kääb, Karl‐Ludwig Laugwitz, Piotr Ponikowski, Stefan D. Anker   +49 more
wiley   +1 more source

Minihepcidins improve ineffective erythropoiesis and splenomegaly in a new mouse model of adult β-thalassemia major

Haematologica, 2019
Minihepcidins are hepcidin agonists that have been previously shown to reverse iron overload and improve erythropoiesis in mice affected by non-transfusion-dependent thalassemia.
C. Casu, Roberta Chessa, Alison Liu, Ritama Gupta, H. Drakesmith, R. Fleming, Y. Ginzburg, B. Macdonald, S. Rivella   +8 more
semanticscholar   +1 more source