Results 51 to 60 of about 85,932 (276)

The TAM receptor tyrosine kinases Axl and Mer drive the maintenance of highly phagocytic macrophages

Frontiers in Immunology, 2022
Many apoptotic thymocytes are generated during the course of T cell selection in the thymus, yet the machinery through which these dead cells are recognized and phagocytically cleared is incompletely understood.
Lidia Jiménez-García, Christopher Mayer, Patrick G. Burrola, Youtong Huang, Maxim N. Shokhirev, Greg Lemke, Greg Lemke   +6 more
doaj   +1 more source

Erythropoiesis [PDF]

, 2020
Abstract Erythropoiesis is a highly regulated, multistep process in which stem cells, after a series of amplification divisions, generate multipotential progenitor cells, then oligo- and finally unilineage erythroid progenitors, and then morphologically recognizable erythroid precursors and mature red cells.
openaire   +2 more sources

A Single 60.000 IU Dose of Erythropoietin Does Not Improve Short-Term Aerobic Exercise Performance in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial

Frontiers in Physiology, 2020
Erythropoietin (EPO) boosts exercise performance through increase in oxygen transport capacity following regular administration of EPO but preclinical study results suggest that single high dose of EPO also may improve exercise capacity.
Thomas Haider, Thomas Haider, Thomas Haider, Victor Diaz, Jamie Albert, Maria Alvarez-Sanchez, Markus Thiersch, Marco Maggiorini, Matthias P. Hilty, Christina M. Spengler, Christina M. Spengler, Max Gassmann, Max Gassmann   +12 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Methods to assess iron and iodine status [PDF]

, 2008
Four methods are recommended for assessment of iodine nutrition: urinary iodine concentration, the goitre rate, and blood concentrations of thyroid stimulating hormone and thyroglobulin.
Zimmermann, M.B.
core   +2 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Is There any Relationship Between the Repeated Complications of Sickle Cell Disease and the Potential Development of Acute Leukemia?

Oncology and Therapy
Sickle cell disease (SCD) is a severe monogenic hereditary hemoglobinopathy that is characterized by repeated clinical and biological manifestations able to generate stress erythopoiesis.
Giovanna Cannas, Mohamed Elhamri, Xavier Thomas   +2 more
doaj   +1 more source

TAM receptors and the regulation of erythropoiesis in mice

Haematologica, 2009
Background TAM receptors (Tyro3, Axl and Mer) are expressed in hematopoietic tissues. The roles of the three receptors in hematopoiesis are, however, largely unknown.
Hongmei Tang, Song Chen, Haikun Wang, Hui Wu, Qingxian Lu, Daishu Han   +5 more
doaj   +1 more source

Fine‐Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation

Advanced Science, 2022
Lipid metabolism is essential for stemness maintenance, self‐renewal, and differentiation of stem cells, however, the regulatory function of cholesterol metabolism in erythroid differentiation is poorly studied.
Zhiyuan Lu, Lixia Huang, Yanxia Li, Yan Xu, Ruihao Zhang, Qian Zhou, Qi Sun, Yi Lu, Junjie Chen, Yuemao Shen, Jian Li, Baobing Zhao   +11 more
doaj   +1 more source

HSCB, a co-chaperone in mitochondrial iron-sulfur cluster biogenesis, is a novel candidate gene for congenital sideroblastic anemia [PDF]

, 2017
Congenital sideroblastic anemias (CSA) are inherited diseases resulting from defects in heme biosynthesis, mitochondrial iron-sulfur cluster (ISC) assembly, or mitochondrial translation.
Crispin, Andrew
core