Results 51 to 60 of about 60,520 (262)

Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics

Frontiers in Cell and Developmental Biology, 2020
Erythropoiesis is the most robust cellular differentiation and proliferation system, with a production of ∼2 × 1011 cells per day. In this fine-tuned process, the hematopoietic stem cells (HSCs) generate erythroid progenitors, which proliferate and ...
Alvaro M. Gonzalez-Ibanez, Alvaro M. Gonzalez-Ibanez, Lina M. Ruiz, Erik Jensen, Cesar A. Echeverria, Valentina Romero, Linsey Stiles, Linsey Stiles, Orian S. Shirihai, Orian S. Shirihai, Alvaro A. Elorza, Alvaro A. Elorza   +11 more
doaj   +1 more source

An intriguing case of a paravertebral extramedullary erythropoiesis presenting as tumor‐mimicking lesion in a patient with eosinophilia with FIP1L1‐PDGFRA rearrangement

Clinical Case Reports, 2022
Extramedullary hematopoiesis in the posterior mediastinum is rare. Our case interested a 28‐year‐old man with a history of eosinophilia with FIP1L1‐PDGFRA fusion gene who had a mediastinal mass surgically excised. Pathological examination concluded to an
Sassi Farah, Houcine Yoldez, Ayadi Rahma, Mlika Mona, Braham Emna, Abdennadher Mahdi, El Mezni Faouzi   +6 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Iron Loading and Overloading due to Ineffective Erythropoiesis

Advances in Hematology, 2010
Erythropoiesis describes the hematopoietic process of cell proliferation and differentiation that results in the production of mature circulating erythrocytes.
Toshihiko Tanno, Jeffery L. Miller
doaj   +1 more source

Effects of Exogenous Transferrin on the Regulation of Iron Metabolism and Erythropoiesis in Iron Deficiency With or Without Anemia

Frontiers in Physiology, 2022
Erythropoietic response is controlled not only by erythropoietin but also by iron. In addition to its role in iron delivery, transferrin also functions as a signaling molecule, with effects on both iron homeostasis and erythropoiesis.
Yihang Li, Ian Miller, Princy Prasad, Nisha Ajit George, Nermi L. Parrow, Robert E. Fleming, Robert E. Fleming   +6 more
doaj   +1 more source

Erythropoietin in heart failure: effects beyond erythropoiesis [PDF]

, 2011
Erythropoietin in Heart Failure: Effects beyond Erythropoiesis Hartfalen is een ernstige cardiologische aandoening met een hoge mortaliteit en morbiditeit. Nieuwe behandelmethoden voor hartfalen zijn daarom gewenst. Het doel van dit proefschrift was het
Ruifrok, Willem-Peter Theodoor,, Ruifrok, Willem-Peter Theodoor   +1 more
core   +15 more sources

Ineffective Erythropoiesis in β-Thalassemia [PDF]

, 2013
In humans, β-thalassemia dyserythropoiesis is characterized by expansion of early erythroid precursors and erythroid progenitors and then ineffective erythropoiesis.
Ivan Cruz Moura, Jean-Antoine Ribeil, Olivier Hermine, Michael Dussiot, Geneviève Courtois, Jean-Benoit Arlet   +5 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Effect of Neopterin on Splenic Erythropoiesis in Mice

Pteridines, 2010
Neopterin is produced by monocytes and is a biomarker for inflammation. We recently found that neopterin induces stromal cells to produce cytokines that suppress erythropoiesis in the bone marrow of mice.
Tsuboi Isao, Harada Tomonori, Oshima Hideki, Aizawa Shin   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source