Results 71 to 80 of about 60,520 (262)
Advanced Science, EarlyView.Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding +7 more
wiley +1 more source
The Neural Crest as the First Production Site of the Erythroid Growth Factor Erythropoietin
Frontiers in Cell and Developmental Biology, 2019 While the neural crest is considered the fourth germ layer that originates a variety of tissues during mammalian development, we recently discovered that some neural crest cells and neuroepithelial cells play a unique role in secreting a vital ...
Ikuo Hirano, Norio Suzuki
doaj +1 more source
Krüppel-Like Factor 1: A Pivotal Gene Regulator in Erythropoiesis
Cells, 2022 Krüppel-like factor 1 (KLF1) plays a crucial role in erythropoiesis. In-depth studies conducted on mice and humans have highlighted its importance in erythroid lineage commitment, terminal erythropoiesis progression and the switching of globin genes from
Cristian Antonio Caria +2 more
doaj +1 more source
Advanced Science, EarlyView.A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen +14 more
wiley +1 more source
SAMD14 Mechanisms in Stress Erythropoiesis [PDF]
, 2023 Red blood cells (RBCs) essential for tissue oxygenation are generated by the process of erythropoiesis. Any decrease in the RBCs or the oxygen-carrying molecule hemoglobin leads to anemia, affecting nearly 1.62 billion people worldwide.
Ray, Suhita
core
Advanced Science, EarlyView.This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan +7 more
wiley +1 more source
New insights into iron regulation and erythropoiesis [PDF]
, 2015 Purpose of reviewIron homeostasis and erythropoiesis regulate each other to ensure optimal delivery of oxygen and iron to cells and tissues. Defining the mechanisms of this crosstalk is important for understanding the pathogenesis of common conditions ...
Nemeth, Elizabeta, Kim, Airie
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PathogensDuring the first week of T. b. brucei infection, pro-inflammatory IFN-γ production drives acute anaemia by promoting red blood cell clearance by activated macrophages in concert with insufficient bone marrow compensation.
Maida Živalj +9 more
doaj +1 more source
Hybrid models in biomedical applications [PDF]
Компьютерные исследования и моделирование, 2019 The paper presents a review of recent developments of hybrid discrete-continuous models in cell population dynamics. Such models are widely used in the biological modelling.
Nikolai M. Bessonov +3 more
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, 1989 peer reviewedSplenic erythropoiesis was demonstrated by surface counting of 59Fe in 129 of 1,350 ferrokinetic studies performed over a 15 year period. These 129 studies were carried out in 108 patients, including 40 with chronic myelogenous leukemia (CML)
Beguin, Yves +3 more
core +1 more source