Results 71 to 80 of about 85,932 (276)

The use of darbepoetin alpha in infants

Сеченовский вестник, 2019
Among the somatic pathology in young children, the most common is anemic syndrome. Until recently, the commonest method for correction of anemia was hemotransfusion, which allows to restore normal hemoglobin quickly, but has the high risk of ...
A. V. Shchegolev, G. Z. Sufianova, A. A. Sufianov, N. E. Ivanova, M. S. Khlestkina   +4 more
doaj   +1 more source

Nucleolar Protein 56 Deficiency in Zebrafish Leads to Developmental Abnormalities and Anemia via p53 and JAK2-STAT3 Signaling

Biology, 2023
Ribosomes are the vital molecular machine for protein translation in a cell. Defects in several nucleolar proteins have been observed in human ribosomopathies.
Fang Liang, Xiaochan Lu, Biyu Wu, Yexin Yang, Wei Qin   +4 more
doaj   +1 more source

Vimentin downregulation is an inherent feature of murine erythropoiesis and occurs independently of lineage [PDF]

, 1990
In mammalian erythropoiesis, the mature cells of the primitive lineage remain nucleated while those of the definitive lineage are anuclear. One of the molecular and structural changes that precedes enucleation in cells of the definitive lineage is the ...
Lazarides, Elias, Sangiorgi, Frank, Woods, Catherine M.   +2 more
core  

Revealing nascent proteomics in signaling pathways and cell differentiation. [PDF]

, 2018
Regulation of gene expression at the level of protein synthesis is a crucial element in driving how the genetic landscape is expressed. However, we are still limited in technologies that can quantitatively capture the immediate proteomic changes that ...
Burlingame, Alma L, Chalkley, Robert J, Forester, Craig M, Oses-Prieto, Juan A, Phillips, Nancy J, Ruggero, Davide, Urisman, Anatoly, Zhang, Li, Zhao, Qian   +8 more
core   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics

Frontiers in Cell and Developmental Biology, 2020
Erythropoiesis is the most robust cellular differentiation and proliferation system, with a production of ∼2 × 1011 cells per day. In this fine-tuned process, the hematopoietic stem cells (HSCs) generate erythroid progenitors, which proliferate and ...
Alvaro M. Gonzalez-Ibanez, Alvaro M. Gonzalez-Ibanez, Lina M. Ruiz, Erik Jensen, Cesar A. Echeverria, Valentina Romero, Linsey Stiles, Linsey Stiles, Orian S. Shirihai, Orian S. Shirihai, Alvaro A. Elorza, Alvaro A. Elorza   +11 more
doaj   +1 more source

An intriguing case of a paravertebral extramedullary erythropoiesis presenting as tumor‐mimicking lesion in a patient with eosinophilia with FIP1L1‐PDGFRA rearrangement

Clinical Case Reports, 2022
Extramedullary hematopoiesis in the posterior mediastinum is rare. Our case interested a 28‐year‐old man with a history of eosinophilia with FIP1L1‐PDGFRA fusion gene who had a mediastinal mass surgically excised. Pathological examination concluded to an
Sassi Farah, Houcine Yoldez, Ayadi Rahma, Mlika Mona, Braham Emna, Abdennadher Mahdi, El Mezni Faouzi   +6 more
doaj   +1 more source

Hepcidin and iron homeostasis during pregnancy. [PDF]

, 2014
Hepcidin is the master regulator of systemic iron bioavailability in humans. This review examines primary research articles that assessed hepcidin during pregnancy and postpartum and report its relationship to maternal and infant iron status and birth ...
Cadwell, Brooke, Day, Jessica, Koenig, Mary Dawn, Nemeth, Elizabeta, Tussing-Humphreys, Lisa   +4 more
core   +1 more source

Effects of Exogenous Transferrin on the Regulation of Iron Metabolism and Erythropoiesis in Iron Deficiency With or Without Anemia

Frontiers in Physiology, 2022
Erythropoietic response is controlled not only by erythropoietin but also by iron. In addition to its role in iron delivery, transferrin also functions as a signaling molecule, with effects on both iron homeostasis and erythropoiesis.
Yihang Li, Ian Miller, Princy Prasad, Nisha Ajit George, Nermi L. Parrow, Robert E. Fleming, Robert E. Fleming   +6 more
doaj   +1 more source

Impact of hospitalized vaso-occlusive crises in the previous calendar year on mortality and complications in adults with sickle cell disease: a French population-based studyResearch in context

The Lancet Regional Health. Europe
Summary: Background: Historically, sickle cell disease (SCD) patients experiencing frequent hospitalized vaso-occlusive crises (HVOC) have been associated with increased mortality, yet recent data reflecting the widespread use of hydroxyurea and ...
Jean-Benoît Arlet, Eléonore Herquelot, Ludovic Lamarsalle, Fanny Raguideau, Pablo Bartolucci   +4 more
doaj   +1 more source