Results 81 to 90 of about 60,520 (262)
American Journal of Hematology, EarlyView.ABSTRACT Although circulating nucleated red blood cells (cNRBCs) have previously been detected in patients with sickle cell disease (SCD), their prevalence and clinical significance during steady‐state disease have not been established. We retrospectively analyzed 270 adults with an SS or Sβ0‐thalassemia genotype.
Ugo Boccadifuoco +7 more
wiley +1 more source
Concurrent Germline RB1 & Mosaic TP53 in a Child With Multiple Childhood Cancers
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT We report a patient with a pathogenic germline variant (PGV) in RB1 and somatic mosaicism for a pathogenic TP53 variant who developed three distinct types of childhood cancer: retinoblastoma, osteosarcoma, and myelodysplastic syndrome (MDS) before the age of 6 years.
Ole Haubjerg Nielsen +8 more
wiley +1 more source
eLife, 2015 NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical for regulation of intracellular iron bioavailability. However, how ferritinophagy flux is controlled and the roles of NCOA4 in iron-dependent processes are ...
Joseph D Mancias +9 more
doaj +1 more source
The Immunomodulation of Erythropoiesis [PDF]
Publisher Copyright: © 2024 by the authors.Severe malarial anemia (SMA) increases the morbidity and mortality of Plasmodium, the causative agent of malaria. SMA is mainly developed by children and pregnant women in response to the infection.
Inês Sá-Pereira +11 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza +12 more
wiley +1 more source
Methods to assess iron and iodine status [PDF]
, 2008 Four methods are recommended for assessment of iodine nutrition: urinary iodine concentration, the goitre rate, and blood concentrations of thyroid stimulating hormone and thyroglobulin.
Zimmermann, Michael B., Zimmermann, M.B.
core +1 more source
BMEMat, EarlyView.The regeneration process following dLhCG engraftment progressed through four distinct and interconnected stages. dLhCG maintained its regenerative efficacy after 6 months of cosmic exposure, supporting its potential application in space medicine.
Xu Hu +8 more
wiley +1 more source
The Shape Shifting Story of Reticulocyte Maturation
Frontiers in Physiology, 2018 The final steps of erythropoiesis involve unique cellular processes including enucleation and reorganization of membrane proteins and the cytoskeleton to produce biconcave erythrocytes. Surprisingly this process is still poorly understood.
Elina Ovchynnikova +7 more
doaj +1 more source
Cytometry Part A, EarlyView.ABSTRACT Routinely used statistical hypothesis tests are often inadequate for longitudinal flow cytometry data, necessitating more sophisticated modeling approaches. Analyzing dynamic biomarker expression across hematopoietic maturation presents several analytical challenges, notably nonlinearity, serial correlation between subsequent stages, and ...
Sixuan Joanna Wang +8 more
wiley +1 more source
Erythropoiesis-related pathways are affected in HCC and HC RBCs.
, 2022 A. Hierarchical clustering analysis of HCC and HC groups using DEPs. B. Interactive networks involving disrupted pathways and proteins constructed using DEPs in HCC and HC groups. C. Enriched biological processes with the highest PAS Z score. D. Volcanic
Fei Pu (749953) +15 more
core +1 more source