Results 61 to 70 of about 85,932 (276)

Prevalence of Inherited Hemoglobin Disorders and Relationships with Anemia and Micronutrient Status among Children in Yaoundé and Douala, Cameroon. [PDF]

, 2017
Information on the etiology of anemia is necessary to design effective anemia control programs. Our objective was to measure the prevalence of inherited hemoglobin disorders (IHD) in a representative sample of children in urban Cameroon, and examine the ...
Brown, Kenneth H, Engle-Stone, Reina, Gimou, Marie-Madeleine, Green, Ralph, Nankap, Martin, Ndjebayi, Alex, Oyono, Yannick, Tarini, Ann, Williams, Thomas N   +8 more
core   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Effect of Neopterin on Splenic Erythropoiesis in Mice

Pteridines, 2010
Neopterin is produced by monocytes and is a biomarker for inflammation. We recently found that neopterin induces stromal cells to produce cytokines that suppress erythropoiesis in the bone marrow of mice.
Tsuboi Isao, Harada Tomonori, Oshima Hideki, Aizawa Shin   +3 more
doaj   +1 more source

Cish knockout mice exhibit similar outcomes to malaria infection despite altered hematopoietic responses

Frontiers in Microbiology, 2023
The Cytokine-inducible Src homology 2 domain-containing (CISH) protein is a negative feedback regulator induced by cytokines that play key roles in immunity and erythropoiesis.
Asha L. Lakkavaram, Saeed Maymand, Wasan Naser, Wasan Naser, Alister C. Ward, Alister C. Ward, Tania F. de Koning-Ward, Tania F. de Koning-Ward   +7 more
doaj   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Iron Loading and Overloading due to Ineffective Erythropoiesis

Advances in Hematology, 2010
Erythropoiesis describes the hematopoietic process of cell proliferation and differentiation that results in the production of mature circulating erythrocytes.
Toshihiko Tanno, Jeffery L. Miller
doaj   +1 more source

"Splenism" - the function of spleen, as the organ conducting the interrelation of the circulatory system and hematopoiesis

Patologìâ, 2013
On Wistar rats splenic involvement into the regulation of erythropoiesis was studied. Splenomegaly was reproduced for this both by ligation of splenic veins and transfusion of suspension of washed erythrocytes that leaded to the pronounced increase in ...
V.I. Filimonov, N.V. Stepanova, I.E. Sukhomlinova, M.A. Tikhonovskaya, G.I. Bessarab, D.A. Putilin, G.V. Pirtya   +6 more
doaj   +1 more source

Comprehensive Analysis of microRNAs in Human Adult Erythropoiesis

Cells, 2021
MicroRNAs (miRNAs) are small non-coding RNAs, which play an important role in various cellular and developmental processes. The study of miRNAs in erythropoiesis is crucial to uncover the cellular pathways that are modulated during the different stages ...
Aneesha Nath, Janakiram Rayabaram, Smitha Ijee, Abhirup Bagchi, Anurag Dutta Chaudhury, Debanjan Roy, Karthik Chambayil, Jyoti Singh, Yukio Nakamura, Shaji R. Velayudhan   +9 more
doaj   +1 more source

Integrative Analyses Identify a cGAS‐STING Pathway‐Driven Signature With Context‐Dependent Roles in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Zhang et al. identify M7core, a critical cGAS‐STING pathway‐driven gene signature that is activated in most lupus patients’ blood and links to lupus disease severity, lymphopenia, and lupus nephritis. They further reveal the diagnostic and pathogenic characteristics of M7core and emphasize the importance of assessing pathway activity before initiating ...
Lele Zhang, Ming‐Ju Amy Lyu, Ze Hong, Jing Sun, Lan Guo, Jiameng Hu, Munire Maimaiti, Chenhui Li, Jinyi Song, Xiang Zhang, Huansha Yu, Chen Wang, Xuan Wang, Haiyang Hu   +13 more
wiley   +1 more source

Erythrocyte enrichment in hematopoietic progenitor cell cultures based on magnetic susceptibility of the hemoglobin [PDF]

, 2012
Using novel media formulations, it has been demonstrated that human placenta and umbilical cord blood-derived CD34+ cells can be expanded and differentiated into erythroid cells with high efficiency.
Irene Georgakoudi, Jeffrey J. Chalmers, Lee R. Moore, Lin Kang, Maciej Zborowski, Marina V. Kameneva, Rui Zhao, Stewart Abbot, Vanessa Voskinarian-Berse, Xiaokui Zhang, Xiaoxia Jin   +10 more
core   +7 more sources