Results 161 to 170 of about 82,538 (246)

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3513-3526, October 2026.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Real-world use of pegylated erythropoietin in CKD-related anemia: an Indian modified Delphi consensus. [PDF]

Front Nephrol
Kher V, Kothari J, Kumar J, Srinivasa S, Kedlaya P, M S, Bhat R, Nair R, Hm M, Sharma R, Sinha VK, C G S, Sharma JK, Macdougall IC.   +13 more
europepmc   +1 more source

Exploring Associations Between Hypoxia, Serum Erythropoietin, and Cognition in Patients With Mood Disorders and Healthy Individuals

Brain and Behavior, Volume 16, Issue 10, October 2026.
ABSTRACT Purpose Moderate repeated hypoxia (MRH) has shown neuroprotective and neuroplastic effects, partly mediated by erythropoietin (EPO) via hypoxia‐inducible factors (HIFs). This study examined the effects of 3 weeks of daily 3.5‐h normobaric hypoxia (12% O2) versus normoxia (20% O2) combined with cognitive training on oxygen saturation (SpO2 ...
Barbara Emilie Rotbøl Ørum, Johanna Mariegaard Schandorff, Viktoria Damgaard, Eya‐Mist Rødgaard, Caroline Fussing Bruun, Morten Meyer, Lars Vedel Kessing, Martin Balslev Jørgensen, Kamilla Woznica Miskowiak   +8 more
wiley   +1 more source

Statement of Retraction: Mechanism of erythropoietin-induced M2 microglia polarization via Akt / Mtor / P70S6k signaling pathway in the treatment of brain injury in premature mice and its effect on biofilm. [PDF]

Bioengineered
europepmc   +1 more source

A Literal Investigation Into the Existence of Leiomyomatous Erythrocytosis and Secretion of Erythropoietin-Like Substances: A Systematic Review. [PDF]

Cureus
Adegunle AO, Olonade IJ, Felix B, Kaza S.   +3 more
europepmc   +1 more source

Cancer and Hypertension: Shared Mechanisms, Treatment Interactions, and Clinical Management

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Cancer and hypertension (HTN) frequently coexist, and their relationship is increasingly recognized as a clinically relevant intersection between oncology and cardiovascular medicine. However, the extent to which this association reflects shared risk factors, common biological mechanisms, or treatment‐related effects remains incompletely ...
Peizhi Jia, Daxin Chen, Jingting Wang, Yupei Guo, Jinhong Liu, Jiumao Lin   +5 more
wiley   +1 more source

Renal anemia: from erythropoietin deficiency to erythropoietin resistance. [PDF]

Front Pharmacol
Chu A, Bu J, Zou X, Zhang Z, Zheng Q, Shi L, Luo M.   +6 more
europepmc   +1 more source

Recent Advances in Research on SHP Family Phosphatases: Signal Regulation Mechanisms and Disease Associations

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT The protein tyrosine phosphatase family comprises a large number of members. Among them, Src homology 2 (SH2) domain‐containing protein tyrosine phosphatases (commonly referred to as the SHP family). Members of the SHP family regulate multiple signaling pathways by catalyzing the dephosphorylation of substrate proteins, thereby participating ...
Xuebin Li, Xiaoqing Duan, Nanxiu Liu, Wangjie Tang, Yi He, Dongsheng Zhou, Jianguo Yan, Yali Zhou   +7 more
wiley   +1 more source

Intermittent exogenous ketosis increases erythropoietin in healthy adults: A randomized, placebo-controlled study with preliminary sex-specific observations. [PDF]

Physiol Rep
Thomsen HH, Sandfeld-Paulsen B, Bjerg LN, Bech JN.   +3 more
europepmc   +1 more source

Daytime Ventilatory and Blood Acid–Base Responses During Ascent to 3500 m Are Larger and More Rapid in Females Than Males

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
We obtained arterial blood gas samples in 38 healthy lowlander participants (18 female; 20 male) before (D0) and undergoing rapid (D2/3) ascent to and resident at (D9/10) 3500 m. Females had a larger magnitude and more rapid time‐course of ventilatory and renally‐mediated blood acid–base acclimatization with rapid ascent.
Nicole V. Bushfield, Benjamin W. L. MacKenzie, Nicole A. Johnson, Rodion Isakovich, Jamie L. Keess, Nicholas D. J. Strzalkowski, Gustavo Zubieta‐Calleja, Richard J. A. Wilson, Trevor A. Day   +8 more
wiley   +1 more source