Results 41 to 50 of about 15,495 (255)

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Strategies to overcome extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases in shigellae

, 2011
Oral cephalosporins and mecillinam are used to treat Shigella infections, but are compromised by extended-spectrum β-lactamases (ESBLs) and plasmid AmpC β-lactamases.
Warner, Marina, Livermore, David M., David M. Livermore, Marina Warner, Tue Nguyen, Shazad Mushtaq, Nguyen, Tue, Mushtaq, Shazad   +7 more
core   +1 more source

Determination of ESBLs, pAmpC-beta-lactamase genes, and plasmid replicon types among Shigella species from different cities in Iran [PDF]

Archives of Razi Institute
Shigella species (spp) are the common gram-negative bacilli isolated from patients with diarrhea. Infection treatment of these genus of bacteria due to increasing resistance to antibiotic agents remains a global challenge.
Seyyed Amin Ayatollahi Mousavi, Mahla Mohammadian, Hossein Hosseini Nave, Parvin Mohseni, Davood Kalantar-Neyestanaki   +4 more
doaj   +1 more source

Duplex Recombinase Polymerase Amplification‐Lateral Flow Assay for Rapid Visual Detection of Critical Antibiotic Resistance Genes in Escherichia coli and Klebsiella pneumoniae From Positive Blood Cultures

Journal of Clinical Laboratory Analysis, EarlyView.
This study developed a pair of duplex RPA‐LFA assays for the simultaneous detection of critical resistance genes, blaCTX‐M/mcr‐1 and blaoxa‐48‐like/blaNDM, from hemoculture samples. Under optimized conditions, duplex RPA was performed at 37°C–38°C for 25 min, followed by LFA for 10–15 min.
Variya Nemidkanam, Pattamaporn Deechart, Nuntaree Chaichanawongsaroj   +2 more
wiley   +1 more source

Efficacy and Pharmacokinetics of the Combination of OP0595 and Cefepime in a Mouse Model of Pneumonia Caused by Extended-Spectrum-Beta-Lactamase-Producing Klebsiella pneumoniae

, 2017
OP0595 (RG6080) is a novel diazabicyclooctane that inhibits class A and C serine beta-lactamases. Although the combination of OP0595 and cefepime (FEP) showed good in vitro activity against extended-spectrum-beta-lactamase (ESBL)-producing pathogens, the
Uno, Naoki, Hiroshi Mukae, Kazuaki Takeda, Hiroo Hasegawa, Kaku, Norihito, Kosuke Kosai, Miyazaki, Taiga, Takeda, Kazuaki, Hasegawa, Hiroo, Koichi Izumikawa, Mukae, Hiroshi, Yanagihara, Katsunori, Taiga Miyazaki, Izumikawa, Koichi, Yoshitomo Morinaga, Katsunori Yanagihara, Norihito Kaku, Naoki Uno, Kosai, Kosuke, Morinaga, Yoshitomo   +19 more
core   +1 more source

Study of occurrence of Multidrug Resistant Escherichia coli Clinical isolates as a result of Extended Spectrum Beta-Lactamase (Esbls) Production

, 2020
Resistance to antibiotics by microorganisms has increased dramatically in the past few years. Resistance to third-generation cephalosporins and other classes of antibiotics is attributed to the production of beta-lactamase genes located on mobile genetic
Abba, P. O, Akor, J. O
core   +1 more source

Shotgun proteomic analysis of ESBL-producing and non-ESBL-producing Klebsiella Pneumoniae clinical isolates

Microbiological Research, 2020
Klebsiella pneumoniae is a pathogenic bacterium that is responsible for a wide range of infections in humans. An increased rate of infections caused by multi-drug-resistant K. pneumoniae has been noted in the last two decades. The association between antimicrobial resistance and virulence is an important topic of study.
Shymaa, Enany, Samira, Zakeer, Ahmed A, Sayed, Sameh, Magdeldin   +3 more
openaire   +2 more sources

On‐site pilot‐scale advanced oxidation pretreatment of hospital wastewater: assessment of pharmaceuticals, pathogens, antibiotic resistance genes and acute ecotoxicity

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Hospital premises generate wastewater containing a wide spectrum of contaminants, such as pharmaceutically active compounds (PhACs), antibiotic resistance genes (ARGs) and pathogenic microorganisms, whilst plenty of them are classified under the antibiotic resistant bacteria (ΑRΒ) category.
Andreas Kaliakatsos, Iosifina Gounaki, Spyros Dokianakis, Georgios Gkotsis, Maria‐Christina Nika, Eleni Aleiferi, Athanasios S Stasinakis, Nikos Katsarakis, Nikolaos S Thomaidis, Thrassyvoulos Manios, Michalis S Fountoulakis, Danae Venieri   +11 more
wiley   +1 more source

Prevalence of extended spectrum β-lactamases (esbls) among enterobacteriaceae in murtala mohammed specialist hospital, Kano, Nigeria

, 2010
Confirmed variants of enterobacteriaceae isolated from 143 patients that attended Murtala Mohammed Specialist Hospital Kano, were screened for extended spectrum β-lactamases (ESBLs) production using Clinical Laboratory Standards Institute (CLSI ...
Aliyu, H, Yusha’u, M, Kumurya, A, Suleiman, K   +3 more
core   +1 more source

Genomic Characteristics of Extended Spectrum β-Lactamase Producing Escherichia coli Isolates Recovered from a District Hospital in China

Infection and Drug Resistance, 2023
Jiayu Shao, Hangdong Dai, Liwei Xu, Shuilong Zhu, Jufang Zhu, Hangyu Fu, Minxia Ge, Xianhong He Department of Clinical Laboratory, the Third People’s Hospital of Xiaoshan, Hangzhou, People’s Republic of ChinaCorrespondence: Xianhong He; Minxia Ge ...
Shao J, Dai H, Xu L, Zhu S, Zhu J, Fu H, Ge M, He X   +7 more
doaj