Drug repurposing for Alzheimer’s disease using a graph-of-thoughts based large language model to infer drug-disease relationships in a comprehensive knowledge graph [PDF]
BioData MiningDrug repurposing (DR) offers a promising alternative to the high cost and low success rate of traditional drug development, especially for complex diseases like Alzheimer’s disease (AD).
Zhiping Paul Wang +10 more
doaj +2 more sources
Cell polarity opposes Jak/STAT-mediated Escargot activation that drives intratumor heterogeneity in a Drosophila tumor model [PDF]
Cell Reports, 2023 Summary: In proliferating neoplasms, microenvironment-derived selective pressures promote tumor heterogeneity by imparting diverse capacities for growth, differentiation, and invasion.
Deeptiman Chatterjee +5 more
doaj +2 more sources
Cohesin controls intestinal stem cell identity by maintaining association of Escargot with target promoters [PDF]
eLife, 2020 Intestinal stem cells (ISCs) maintain regenerative capacity of the intestinal epithelium. Their function and activity are regulated by transcriptional changes, yet how such changes are coordinated at the genomic level remains unclear. The Cohesin complex
Aliaksandr Khaminets +4 more
doaj +2 more sources
Toxic and Potentially Toxic Mineral Elements of Edible Gastropods Land Snails (Mediterranean Escargot) [PDF]
Toxics, 2023 The meat of snails can be considered a high-quality food for the human diet and demand is already increasing across Europe. Due to the bioaccumulation of trace elements in their tissues, land snails can be a significant tool also for environmental ...
Roberta Tardugno +7 more
doaj +2 more sources
The intestinal stem cell/enteroblast-GAL4 driver, escargot-GAL4, also manipulates gene expression in the juvenile hormone-synthesizing organ of Drosophila melanogaster [PDF]
Scientific ReportsIntestinal stem cells (ISCs) of the fruit fly, Drosophila melanogaster, offer an excellent genetic model to explore homeostatic roles of ISCs in animal physiology.
Yoshitomo Kurogi +3 more
doaj +2 more sources
ESCARGOT: Mapping Vertical Phase Spiral Characteristics Throughout the Real and Simulated Milky Way
The Astrophysical Journal, 2023 The recent discovery of a spiral pattern in the vertical kinematic structure in the solar neighborhood provides a prime opportunity to study nonequilibrium dynamics in the Milky Way from local stellar kinematics.
Elise Darragh-Ford +3 more
doaj +1 more source
Identification of an α‑MoRF in the Intrinsically Disordered Region of the Escargot Transcription Factor [PDF]
ACS Omega, 2020 Teresa Hernández-Segura, Nina Pastor
doaj +2 more sources
PERSEPSI KONSUMEN ATAS KUALITAS PRODUK GOTCHA ESCARGOT CHIPS PADA PERUSAHAAN SINERGI PEMENANG
Jurnal Performa, 2018 Pakar kuliner seperti Tendi Naim dan Arie Parikesit memperkirakan tren makanan yang akan semakin popular selanjutnya adalah healthy food, khususnya di kalangan masyarakat perkotaan.
Meilita Priskila, Sonata Christian
doaj +1 more source
Rac1 drives intestinal stem cell proliferation and regeneration [PDF]
, 2013 Adult stem cells are responsible for maintaining the balance between cell proliferation and differentiation within self-renewing tissues. The molecular and cellular mechanisms mediating such balance are poorly understood.
Alessandro Scopelliti +28 more
core +1 more source
Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut [PDF]
, 2015 Adult tissue homeostasis requires a tight balance between the removal of old or damaged cells and the production of new ones. Such processes are usually driven by dedicated stem cells that reside within specific tissue locations or niches.
Carroll, Lynsey +2 more
core +1 more source