Results 51 to 60 of about 1,541,055 (356)

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Virulence plasmids in edema disease: Insights from whole-genome analysis of porcine O139:H1 Shiga toxin-producing Escherichia coli (STEC) strains

Frontiers in Cellular and Infection Microbiology
This study investigates the plasmid sequences of porcine O139:H1 Shiga toxin-producing Escherichia coli (STEC) responsible for Edema Disease (ED). Whole-genome analysis reveals significant similarities between these strains and known plasmids, notably ...
Ali Nemati, Ali Nemati, Federica Gigliucci, Stefano Morabito, Mahdi Askari Badouei   +4 more
doaj   +1 more source

New tools for recombinant protein production in Escherichia coli: A 5‐year update

Protein Science, 2019
The production of proteins in sufficient amounts is key for their study or use as biotherapeutic agents. Escherichia coli is the host of choice for recombinant protein production given its fast growth, easy manipulation, and cost‐effectiveness.
Germán L. Rosano, Enrique S Morales, E. Ceccarelli   +2 more
semanticscholar   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

The Intriguing Evolutionary Journey of Enteroinvasive E. coli (EIEC) toward Pathogenicity

Frontiers in Microbiology, 2017
Among the intestinal pathogenic Escherichia coli, enteroinvasive E. coli (EIEC) are a group of intracellular pathogens able to enter epithelial cells of colon, multiplicate within them, and move between adjacent cells with a mechanism similar to Shigella,
Martina Pasqua, Valeria Michelacci, Maria Letizia Di Martino, Rosangela Tozzoli, Milena Grossi, Bianca Colonna, Stefano Morabito, Gianni Prosseda   +7 more
doaj   +1 more source

Serotype-dependent adhesion of Shiga toxin-producing Escherichia coli to bovine milk fat globule membrane proteins

Frontiers in Microbiology, 2022
Shiga toxin-producing Escherichia coli (STEC) are food-borne pathogens that can cause severe symptoms for humans. Raw milk products are often incriminated as vehicule for human STEC infection.
Arthur Bagel, Christelle Lopez, Elisabeth David-Briand, Valérie Michel, Thomas Douëllou, Delphine Sergentet, Delphine Sergentet   +6 more
doaj   +1 more source

Structure and genetics of Escherichia coli O antigens

FEMS Microbiology Reviews, 2019
Escherichia coli includes clonal groups of both commensal and pathogenic strains, with some of the latter causing serious infectious diseases. O antigen variation is current standard in defining strains for taxonomy and epidemiology, providing the basis ...
B. Liu, Axel Furevi, A. Perepelov, Xi Guo, Hengchun Cao, Quan Wang, P. Reeves, Y. Knirel, Lei Wang, G. Widmalm   +9 more
semanticscholar   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli

mBio, 2017
The mobile colistin resistance gene mcr-1 has attracted global attention, as it heralds the breach of polymyxins, one of the last-resort antibiotics for the treatment of severe clinical infections caused by multidrug-resistant Gram-negative bacteria.
Wenjuan Yin, Hui Li, Yingbo Shen, Zhihai Liu, Shaolin Wang, Zhangqi Shen, Rong Zhang, T. Walsh, Jianzhong Shen, Yang Wang   +9 more
semanticscholar   +1 more source