Results 51 to 60 of about 700,150 (263)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Antimicrobial resistance and virulence gene profiles of Escherichia coli isolated from poultry farms using One Health perspective in Abeokuta, Nigeria

BMC Microbiology
Background Antimicrobial resistant Extraintestinal pathogenic Escherichia coli (ExPEC) includes uropathogenic E. coli (UPEC), the causative agents of urinary tract infections (UTI), neonatal meningitis E. coli (NMEC), implicated in neonatal meningitis in
A. T. Ajibola, M. de Lagarde, O. E. Ojo, S. A. Balogun, G. Vanier, J. M. Fairbrother, O. B. Shittu   +6 more
doaj   +1 more source

Phenotypic and Genotypic Characterization of ESBL-, AmpC-, and Carbapenemase-Producing Klebsiella pneumoniae and High-Risk Escherichia coli CC131, with the First Report of ST1193 as a Causative Agent of Urinary Tract Infections in Human Patients in Algeria

Antibiotics
Background: High-risk Escherichia coli clones, such as sequence type (ST)131 and ST1193, along with multidrug-resistant (MDR) Klebsiella pneumoniae, are globally recognized for their significant role in urinary tract infections (UTIs).
Hajer Ziadi, Fadela Chougrani, Abderrahim Cheriguene, Leticia Carballeira, Vanesa García, Azucena Mora   +5 more
doaj   +1 more source

Comparative Genomics of Recent Shiga Toxin-Producing Escherichia coli O104:H4: Short-Term Evolution of an Emerging Pathogen

mBio, 2013
The large outbreak of diarrhea and hemolytic uremic syndrome (HUS) caused by Shiga toxin-producing Escherichia coli O104:H4 in Europe from May to July 2011 highlighted the potential of a rarely identified E. coli serogroup to cause severe disease.
Yonatan H. Grad, Paul Godfrey, Gustavo C. Cerquiera, Patricia Mariani-Kurkdjian, Malika Gouali, Edouard Bingen, Terrence P. Shea, Brian J. Haas, Allison Griggs, Sarah Young, Qiandong Zeng, Marc Lipsitch, Matthew K. Waldor, François-Xavier Weill, Jennifer R. Wortman, William P. Hanage   +15 more
doaj   +1 more source

ClassifyingEscherichia coli

Emerging Infectious Diseases, 2006
To the Editor: Enteropathogenic Escherichia coli (EPEC), 1 of the 6 pathotypes of diarrheogenic E. coli (DEC), promotes attaching-effacing lesions in eukaryotic cells. These lesions are mediated by intimin, an outer membrane adhesive protein encoded by the eae (E. coli attaching-effacing) gene (1). EPEC is currently subdivided into typical and atypical
Dennys M. Girão, Valéria B.C. Girão, Kinue Irino, Tânia A. Tardelli Gomes   +3 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Perbandingan kecepatan pertumbuhan Escherichia coli non ESBL dengan Escherichia coli ESBL

JKS (Jurnal Kedokteran Syiah Kuala), 2020
Abstrak. Penelitian ini bertujuan untuk mengidentifikasi perbedaan kecepatan pertumbuhan antara kelompok bakteri Escherichia coli NON ESBL dengan kelompok Escherichia coli ESBL. Jenis dan rancangan penelitian ini adalah penelitian eksperimental.
Branandito Putra, Linda Dewanti, Eddy Bagus Wasito   +2 more
doaj   +1 more source

Escherichia coli Biofilms

, 2008
Escherichia coli is a predominant species among facultative anaerobic bacteria of the gastrointestinal tract. Both its frequent community lifestyle and the availability of a wide array of genetic tools contributed to establish E. coli as a relevant model organism for the study of surface colonization.
Beloin, Christophe, Roux, Agnès, Ghigo, Jean-Marc   +2 more
openaire   +4 more sources