Results 71 to 80 of about 967,635 (317)

Analysis of the genetic and phylogenetic context of Escherichia coli O77g:H18 associated with clustered cases of HUS in France in 2025

Applied and Environmental Microbiology
In January 2025, Santé publique France detected several cases of hemolytic uremic syndrome (HUS) in adults caused by a rare serotype of Shiga toxin-producing Escherichia coli, STEC O77g:H18.
Fabien Vorimore, Mai-Lan Tran, Aurélie Cointe, Justine de Larminat, Philippe Bidet, Stéphane Bonacorsi, Carolina Silva Nodari, François-Xavier Weill, Patrick Fach, Sabine Delannoy   +9 more
doaj   +1 more source

Comparative Genomics of Recent Shiga Toxin-Producing Escherichia coli O104:H4: Short-Term Evolution of an Emerging Pathogen

mBio, 2013
The large outbreak of diarrhea and hemolytic uremic syndrome (HUS) caused by Shiga toxin-producing Escherichia coli O104:H4 in Europe from May to July 2011 highlighted the potential of a rarely identified E. coli serogroup to cause severe disease.
Yonatan H. Grad, Paul Godfrey, Gustavo C. Cerquiera, Patricia Mariani-Kurkdjian, Malika Gouali, Edouard Bingen, Terrence P. Shea, Brian J. Haas, Allison Griggs, Sarah Young, Qiandong Zeng, Marc Lipsitch, Matthew K. Waldor, François-Xavier Weill, Jennifer R. Wortman, William P. Hanage   +15 more
doaj   +1 more source

Enteroaggregative Escherichia coli [PDF]

Journal of Applied Microbiology, 1998
Enteroaggregative Escherichia coli (EAggEC) are a group of E. coli characterized by the ability to adhere to cultured cell monolayers with an aggregative or 'stacked brick' adhesion phenotype. These strains of E. coli are distinct from other pathogenic groups of E. coli.
D, Law, H, Chart
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Biotyping of Escherichia coli [PDF]

Journal of Medical Microbiology, 1979
We examined the results of tests with 22 substrates for their ability to discriminate a series of 917 strains of Escherichia coli collected from different sources. The tests with three of the substrates were discarded because of difficulties in performance or interpretation, and another nine substrates because they provided little discrimination.
P B, Crichton, D C, Old
openaire   +2 more sources

Escherichia coli K1 RS218 Interacts with Human Brain Microvascular Endothelial Cells via Type 1 Fimbria Bacteria in the Fimbriated State

, 2005
Escherichia coli K1 is a major gram-negative organism causing neonatal meningitis. E. coli K1 binding to and invasion of human brain microvascular endothelial cells (HBMEC) are a prerequisite for E.
Shin, S., Kim, K.J., di Cello, F., Cai, M., Khan, Naveed Ahmed, Xie, Y., Kim, K.S., Teng, C.H.   +7 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Perbandingan kecepatan pertumbuhan Escherichia coli non ESBL dengan Escherichia coli ESBL

JKS (Jurnal Kedokteran Syiah Kuala), 2020
Abstrak. Penelitian ini bertujuan untuk mengidentifikasi perbedaan kecepatan pertumbuhan antara kelompok bakteri Escherichia coli NON ESBL dengan kelompok Escherichia coli ESBL. Jenis dan rancangan penelitian ini adalah penelitian eksperimental.
Branandito Putra, Linda Dewanti, Eddy Bagus Wasito   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source