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Esculetin and idebenone ameliorate galactose‐induced cataract in a rat model
Journal of Food Biochemistry, 2020Cataract is the principal cause of blindness. The enzyme, aldose reductase (AR) is a key player in polyol pathway. Buildup of polyols and oxidative stress are the main causes of cataractogenesis. This study investigated the cytoprotective properties of esculetin and idebenone in galactose-induced cataract. Rats were partitioned into four groups each of
Nermin Abdel Hamid Sadik +3 more
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Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1983Esculetin (6,7-dihydroxycoumarin) showed inhibitory effects on 5- and 12-lipoxygenases of cloned mastocytoma cells. The half-inhibition dose (ID50) for each enzyme was 4 X 10(-6) and 2.5 X 10(-6) M, respectively. No inhibition at all, but rather a stimulating effect on prostaglandin synthesis, was observed, especially at higher doses of esculetin ...
T, Neichi, Y, Koshihara, S, Murota
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Esculetin Induces Apoptosis and Inhibits Adipogenesis in 3T3‐L1 Cells
Obesity, 2006AbstractObjective: To determine the effects of esculetin, a plant phenolic compound with apoptotic activity in cancer cells, on 3T3‐L1 adipocyte apoptosis and adipogenesis.Research Methods and Procedures: 3T3‐L1 pre‐confluent preadipocytes and lipid‐filled adipocytes were incubated with esculetin (0 to 800 μM) for up to 48 hours.
Jeong-Yeh, Yang +5 more
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Evaluation of Percutaneous Absorption of Esculetin: Effect of Chemical Enhancers
Planta Medica, 2012Percutaneous transdermal absorption of esculetin (6,7-dihydroxycoumarin), an oxidative damage inhibitor, was evaluated by means of in vitro permeation studies in which vertical Franz-type diffusion cells and pig ear skin were employed. To determine the absorption of esculetin, we validated a simple, accurate, precise, and rapid HPLC-UV method ...
Sergio, del Rio Sancho +7 more
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Anti-inflammatory and peripheral analgesic activity of esculetin in vivo
Pharmacological Research Communications, 1988Esculetin determined a reduction in oedema and granulocyte infiltration in the Croton oil ear test in vivo. The drug was able to inhibit Acethylcholine-writhing test and showed a LD50 of 1450 mg/kg i.p. and greater than 2000 mg/kg by mouth. In our experimental conditions, esculetin has an anti-inflammatory and analgesic effect.
TUBARO, AURELIA +4 more
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Esculetin regulates the phenotype switching of airway smooth muscle cells
Phytotherapy Research, 2019Airway remodeling is one important feature of childhood asthma, which is one of the most common chronic childhood diseases. Phenotype switching of airway smooth muscle cells (ASMCs), defined as a reversible switching between contractile and proliferative phenotypes, plays an important role in the process of airway remodeling.
Chundan Xie +3 more
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Esculetin in Alchemilla speciosa: identification and antimutagenic properties.
Die Pharmazie, 1997Quercetin, an ubiquitously occurring plant mutagen was detected and quantified in a methanolic extract prepared from the herb of Alchemilla speciosa BUSER (Rosaceae). However, the extract exhibited much less mutagenicity in Salmonella typhimurium than expected from its quercetin content.
O, Schimmer, H, Eschelbach
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Esculetin; 6,7-dihydroxycoumarin
Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry, 1977K. Ueno, N. Saito
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Acta Pharmacologica Sinica
Esculetin (ESC) is a coumarin-derived phytochemical prevalent in traditional Chinese medicine that exhibits anti-acute ischemic stroke activities. Our previous studies demonstrate that CKLF1 is a potential anti-stroke target for coumarin-derived compound.
Jia-Qi, He +14 more
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Esculetin (ESC) is a coumarin-derived phytochemical prevalent in traditional Chinese medicine that exhibits anti-acute ischemic stroke activities. Our previous studies demonstrate that CKLF1 is a potential anti-stroke target for coumarin-derived compound.
Jia-Qi, He +14 more
openaire +2 more sources