Results 1 to 10 of about 7,313 (199)

Esketamine as an opioid-sparing adjuvant for epidural labour analgesia: a randomised, double-blind trial evaluating postpartum depression [PDF]

BMC Anesthesiology
Background Opioid-based epidural analgesia, while effective, is frequently associated with maternal side effects such as pruritus and potential central sensitisation.
Yi-ying Zhang, Xu-li Cheng, Li Liu, Lin Li, Yugang Diao   +4 more
doaj   +2 more sources

Dose-dependent effects of esketamine on the prevention of propofol-induced injection pain: a randomized controlled trial [PDF]

BMC Anesthesiology
Background In our previous study, we showed that a low dose of esketamine could alleviate propofol-induced injection pain during general anesthesia induction. However, the dose-response relationship of esketamine remains unclear.
Danyun Fu, Yilei Shen, Hongyan Xiao, Jie Jia   +3 more
doaj   +2 more sources

Effect of esketamine on hypotension in women with preoperative anxiety undergoing elective cesarean section: a randomized, double-blind, controlled trial [PDF]

Scientific Reports
To investigate the effect of low-doses esketamine on spinal anesthesia-induced hypotension in women with preoperative anxiety undergoing elective cesarean section, the randomized controlled trial enrolled 120 women aged 18–35 years who preoperative State-
Yu Qi, Meiyan Zhou, Yaqi Dong, Wenting Zheng, Qinyu Jiang, Yanyu Li, Xinghe Wang, Jia Sun, Hai Zhou, Zhengquan Hu, Liwei Wang   +10 more
doaj   +3 more sources

Auto-Induction in Oral Esketamine Treatment for Treatment-Resistant Depression: An Exploratory Study [PDF]

Pharmaceuticals
Background: Esketamine is a rapidly acting antidepressant with robust efficacy in treatment-resistant depression (TRD). Diminishing therapeutic effects and attenuated side effects have been reported after long-term use.
Jolien K. E. Veraart, Cornelis F. Vos, Nieko C. Punt, Dylan Visser, Mireille A. Wessels, Sanne Y. Smith-Apeldoorn, Jeanine Kamphuis, Robert A. Schoevers, Daan J. Touw   +8 more
doaj   +3 more sources

Plasma esketamine and noresketamine levels and antidepressant response with oral esketamine treatment [PDF]

European Journal of Pharmacology
OBJECTIVE: Oral esketamine has relatively low and variable bioavailability, which may complicate broader use as an antidepressant. This study aimed to investigate associations between different pharmacokinetic outcomes and change in depressive symptoms ...
Kamphuis, Jeanine, Schoevers, Robert A, Smith-Apeldoorn, Sanne Y, Touw, Daan J, Veraart, Jolien K E   +4 more
core   +4 more sources

Efficacy and safety of esketamine for "treatment resistant depression": registered report for a systematic review with an individual patient data meta-analysis of randomized, double-blind, placebo-controlled trials. [PDF]

BMC Med
Background: In 2019, the FDA and EMA approved intranasal esketamine for treatment-resistant depression (TRD). The current study re-evaluated its efficacy and safety. Methods: This registered report presents a systematic review and individual patient data
Naudet F, Pellen C, Fodor LA, Gastaldon C, Barbui C, Turner EH, Le Pabic E, Cristea IA.   +7 more
europepmc   +3 more sources

Moderate-to-deep sedation technique, using propofol and ketamine, allowing synchronised breathing for magnetic resonance high-intensity focused ultrasound (MR-HIFU) treatment for uterine fibroids: a pilot study [PDF]

, 2017
BACKGROUND: Magnetic resonance high-intensity focused ultrasound (MR-HIFU) treatment for uterine fibroids is rapidly gaining popularity as a treatment modality.
F. M. Knuttel, Hermanus H. B. Vaessen, J. M. Dieleman, J. M. M. van Breugel, J. T. A. Knape, M. A. A. J. van den Bosch, M. E. Ikink   +6 more
core   +10 more sources

Intermittent versus continuous esketamine infusions for long-term pain modulation in complex regional pain syndrome: protocol of a randomized controlled non-inferiority study (KetCRPS-2)

BMC Musculoskeletal Disorders, 2023
Background Complex regional pain syndrome (CRPS) is a chronic pain condition of an extremity. While achieving pain relief in CRPS is challenging, esketamine infusions can accomplish pain relief for several weeks post-infusion in a subgroup of CRPS ...
Thomas J. P. Mangnus, Maaike Dirckx, Krishna D. Bharwani, Sara J. Baart, Theodora A. M. Siepman, Ken Redekop, Willem A. Dik, Cecile C. de Vos, Frank J. P. M. Huygen   +8 more
doaj   +1 more source

Efficacy and safety of esketamine for sedation among patients undergoing gastrointestinal endoscopy: a systematic review and meta-analysis

BMC Anesthesiology, 2023
Background Patients who undergo gastrointestinal endoscopy often require propofol-based sedation combined with analgesics. At present, the efficacy and safety of esketamine as an adjunct to propofol for sedation during endoscopic procedures in patients ...
Xianghong Lian, Yunzhu Lin, Ting Luo, Yang Jing, Hongbo Yuan, Yixin Guo   +5 more
doaj   +1 more source

Midazolam Attenuates Esketamine-Induced Overactive Behaviors in Mice Before the Sedation, but Not During the Recovery

Frontiers in Veterinary Science, 2022
Esketamine showed more potency, more rapid recovery from anesthesia, and less psychotomimetic side effects when compared with ketamine. However, the patients still experience psychotomimetic side effects of esketamine.
Qinjun Chu, Meng Mao, Yafan Bai, Liwei Sun, Dongqing Zhang, Ping Zheng, Xiaogao Jin, Xiaogao Jin, Xiaogao Jin, Xiaogao Jin   +9 more
doaj   +1 more source