Esketamine/Ketamine: Dual-Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology. [PDF]
Adv Sci (Weinh)Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Wang Y +7 more
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The Ketamine Side Effect Tool (KSET):A comprehensive measurement-based safety tool for ketamine treatment in psychiatry [PDF]
, 2022 Objectives: On a background of the rapidly expanding clinical use of ketamine and esketamine for treatment of depression and other conditions, we examined safety monitoring, seeking to identify knowledge gaps relevant to clinical practice.
Bayes, Adam +17 more
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Scientific Reports, 2023 Esketamine provides an immediate and noticeable antidepressant effect, although the underlying molecular processes are yet unclear. Irisin induced by aerobic exercise has been implicated in the alleviation of depressive symptoms, whether irisin ...
Na Hu +9 more
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BMC Anesthesiology, 2022 Background Esketamine is an antagonist of the N-methyl-D-aspartate receptor (NMDA receptor) that is widely used for multimodal analgesia. In addition to analgesia, sedation is another important effect of esketamine.
Cao Zhang +4 more
doaj +1 more source
Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs [PDF]
, 2020 Intranasal ketamine has recently gained interest in human medicine, not only for its sedative, anaesthetic or analgesic properties, but also in the management of treatment resistant depression, where it has been shown to be an effective, fast acting ...
Croubels, Siska +6 more
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Efficacy of new-generation antidepressants assessed with the Montgomery-Asberg depression rating scale, the gold standard clinician rating scale : a meta-analysis of randomised placebo-controlled trials [PDF]
, 2020 It has been claimed that efficacy estimates based on the Hamilton Depression Rating-Scale (HDRS) underestimate antidepressants true treatment effects due to the instrument's poor psychometric properties.
Hengartner, Michael Pascal +3 more
core +2 more sources
pharma-kritik, 2021 In Form eines Nasensprays (Spravato®) ist das S-Enantiomer von Ketamin zur Behandlung einer «therapieresistenten» Depression zugelassen. Hinsichtlich der psychischen Auswirkungen teilt diese Form die Eigenschaften von Ketamin.
openaire +1 more source
Esketamine Anesthetizes Mice With a Similar Potency to Racemic Ketamine
Dose-Response, 2023 Esketamine, the right-handed optical isomer of racemic ketamine, has recently become widely used for anesthesia and analgesia as a replacement for racemic ketamine.
Xiaofan Ma +6 more
doaj +1 more source
Frontiers in Pharmacology, 2022 We designed a four-arm randomized controlled trial to investigate the median effective concentration (EC50) of propofol in combination with different doses of esketamine inducing appropriate depth of anaesthesia during gastrointestinal endoscopy in ...
Miaomiao Feng +11 more
doaj +1 more source
The antidepressant effect and safety of non-intranasal esketamine:A systematic review [PDF]
, 2022 BACKGROUND: The introduction of esketamine into the field of psychiatry comes on the heels of excitement from studies on racemic ketamine. While the intranasal route has been the most studied to date, other modes of administration of esketamine may also ...
Aan Het Rot, Marije +5 more
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