Results 61 to 70 of about 7,313 (199)

Psychedelic‐ and Substance‐Assisted Therapies in Global Mental Health: Bridging Cultures, Evidence, and Access,

Brain and Behavior, Volume 16, Issue 2, February 2026.
Psychedelic‐ and substance‐assisted therapies, including MDMA, psilocybin, and ketamine, are gaining attention for conditions such as PTSD and depression, yet their development and implementation remain largely concentrated in high‐income settings. This graphical abstract summarizes the central argument of the commentary: while these interventions may ...
Simon Halm
wiley   +1 more source

Esketamine for treatment resistant depression: a trick of smoke and mirrors? [PDF]

, 2019
In March 2019, the US Food and Drug Administration (FDA) approved a nasal spray formulation of esketamine for the treatment of resistant depression in adults.
Barbui, C., Gastaldon, C., Ostuzzi, G., Papola, D.   +3 more
core   +2 more sources

Hope for Neurotic Disorders: A Summary of New Zealand Research on the Development of Biomarkers and Novel Treatments

Journal of the Royal Society of New Zealand, Volume 56, Issue 1, February 2026.
The neurotic disorders (e.g., depression, dysthymia, generalized anxiety disorder, panic disorder, agoraphobia, social anxiety, post‐traumatic stress disorder, and obsessive–compulsive disorder) are costly and difficult to treat. Diagnosis is based on symptoms not biological causes.
Neil McNaughton, Shabah M. Shadli, B. Beaglehole, Paul Glue   +3 more
wiley   +1 more source

Esketamine vs. placebo combined with erector spinae plane block vs. intercostal nerve block on quality of recovery following thoracoscopic lung resection: A randomized controlled factorial trial. [PDF]

Multimodal analgesic strategy is pivotal for enhanced recovery after surgery. The objective of this trial was to assess the effect of subanesthetic esketamine vs. placebo combined with erector spinae plane block (ESPB) vs.
Chen, Shaomu, Hu, Jing-Hui, Ji, Fu-Hai, Liu, Hong, Liu, Hua-Yue, Meng, Lingzhong, Peng, Ke, Shan, Xi-Sheng, Shi, Hai-Jing, Wang, Jie, Zhong, Zhang-Zhen   +10 more
core   +1 more source

Effect of peri‐operative pharmacological interventions on postoperative delirium in patients having cardiac surgery: a systematic review and Bayesian network meta‐analysis

Anaesthesia, Volume 81, Issue 2, Page 274-287, February 2026.
Summary Introduction Postoperative delirium is a common complication following cardiac surgery. Despite its known impact on patient outcomes, effective preventative strategies remain elusive. We aimed to perform a comprehensive Bayesian network meta‐analysis of randomised controlled trials assessing the effect of pharmacological interventions on the ...
Ivo Queiroz, Lucas M. Barbosa, Mariano Gallo Ruelas, Beatriz Araújo, Maria L. R. Defante, Arthur H. Tavares, Cynthia Florencio de Mesquita, Tulio Pimentel, Beatriz Ximenes Mendes, Iuri Ferreira Felix, André Rivera, Rafael Oliva Morgado Ferreira, Helen M. de Oliveira, Bruno B. Righetto, Nathan J. Smischney, Guangyu Tong, Daqing Ma   +16 more
wiley   +1 more source

Esketamine use in real-world clinical practice in patients with treatment-resistant depression

European Psychiatry
Background Esketamine has been shown to produce a major antidepressant response in patients with treatment-resistant depression (TRD). We evaluated the factors associated with achieving remission in these individuals.
Ismael Conejero, Raquel Alvarez García, Alejandro Porras-Segovia, Ana María De Granda Beltrán, Sergio Benavente López, Ezequiel Di Stasio, Lucía Albarracín-García, Jorge Lopez-Castroman, Philippe Courtet, Enrique Baca-Garcia   +9 more
doaj   +1 more source

Ketamine Combined With Psychotherapy as a Treatment for Resistant Depression in a Public European Hospital

Brain and Behavior, Volume 16, Issue 1, January 2026.
This retrospective study evaluated ketamine infusions combined with psychotherapy in nine patients with treatment‐resistant depression at a general hospital. After eight weeks, all participants improved, with PHQ‐9 scores shifting from severe to moderate. Overall, 44% responded to treatment, and among those with suicidal ideation, more than half showed
Filipa Alves da Silva, Rita Avelar, Bernardo Peixoto, Leonor Bacelar‐Nicolau, Francisco Santos, João Costa Ribeiro, Maria João Heitor   +6 more
wiley   +1 more source

A Novel Tertiary Carbamate Prodrug Strategy to Overcome Metabolic Barriers in Oral Ketamine Delivery

ChemMedChem, Volume 21, Issue 2, January 2026.
This study describes the development of an orally optimized ketamine prodrug designed to improve pharmacokinetic properties, extend therapeutic efficacy, and minimize adverse effects and abuse liability. Ketamine, a rapid‐acting N‐methyl‐D‐aspartate (NMDA) receptor antagonist, has therapeutic potential beyond anesthesia, including treatment‐resistant ...
Juulia Järvinen, Santosh Kumar Adla, Janne Tampio, Aaro Jalkanen, Kenneth B. Sloan, Kristiina M. Huttunen, Jarkko Rautio   +6 more
wiley   +1 more source

The effect of low-dose esketamine on maternal depression after cesarean delivery

Journal of Psychosomatic Obstetrics and Gynecology
Objective To assess the impact of low-dose intravenous esketamine on postpartum depression scores in women undergoing cesarean section.Methods In a randomized, double-blind, placebo-controlled trial, 186 women aged 20–50 years receiving epidural ...
Yan Shang, Siyuan Li, Qin Zheng, Tingting Mi, Yuzhu Lv, Lichun Han, Binrong Wang   +6 more
doaj   +1 more source

A Review of Nanoparticle‐Based Astrocyte Modulation in CNS Disorders: Evaluating the Underexplored Potential of Intranasal Delivery

Nano Select, Volume 7, Issue 1, January 2026.
Nanoparticle‐driven nose‐to‐brain drug delivery offers a noninvasive approach to bypass the blood–brain barrier (BBB) and directly modulate reactive astrocytes in CNS disorders. This review highlights biodegradable nanoparticles for astrocyte modulation, enhancing drug bioavailability, sustained release, and neuroinflammation control.
Senamile M. Dlamini, Gillian D. Mahumane, Pradeep Kumar, Yahya E. Choonara   +3 more
wiley   +1 more source