Results 71 to 80 of about 7,313 (199)

The Association between Intranasal Esketamine and Treatment- emergent Insomnia in the Treatment of Treatment-resistant Major Depression:A Meta-analysis [PDF]

ObjectiveIntranasal (IN) esketamine represents a novel add-on treatment for treatment-resistant depression (TRD) with reported favourable effects on insomnia.
Boesjes, Rutger, Kamphuis, Jeanine, Schoevers, Robert A., Türkmen, Cagdas, van Dalfsen, Jens, Viechtbauer, Wolfgang, Zandbergen, Anne Fleur   +6 more
core   +1 more source

Pharmacotherapeutic Controversies During Temperature Control After Out‐of‐Hospital Cardiac Arrest: A Semi‐Structured Literature Review

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 1, January 2026.
ABSTRACT Post‐resuscitation cardiac arrest care begins at the time of hospital admission and focuses on preventing the sequelae of ischemia–reperfusion injury, including secondary brain damage and post‐cardiac arrest syndrome. Clinical practice guidelines on post‐resuscitation cardiac arrest care from international medical organizations outline ...
Christy Cecil Forehand, Scott Thomas Benken, Melanie Madorsky, Adham Mohamed, Jerika V. Nguyễn, Deepali Dixit, Jolie Gallagher, William Anthony Hawkins, Mojdeh Saba Heavner, Emory Johnson, Lauren Lozano, Melanie Sisco, Angela A. Slampak‐Cindric, Susan Elizabeth Smith, Katherine Spezzano, Bayard Angel Taylor II, Nathaniel Brett Wayne, David John Gagnon   +17 more
wiley   +1 more source

Safety and Efficacy of Adjunctive Esketamine vs. MAOIs in TRD in Adults [PDF]

, 2023
Background: Depression affects millions globally - Treatment-resistant depression (TRD) is defined as failure to respond to two antidepressant trials of adequate dose and duration Traditional Treatment for TRD: Switching or adding medications atypical ...
Guinan, Riley
core   +1 more source

Association of Cerebral Oxygenation During Prehospital Anaesthesia and Functional Outcome: A Prospective, Observational Multi‐Centre Cohort Study of 1014 Patients

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 1, January 2026.
ABSTRACT Background Many patients undergoing prehospital anaesthesia may be at risk of inadequate cerebral oxygenation due to underlying conditions or adverse events like hypotension or hypoxia. This study examined whether a decrease in regional cerebral oxygen saturation (rSO2) measured with near‐infrared spectroscopy (NIRS) during prehospital ...
Anssi Saviluoto, Lasse Raatiniemi, Simo Mäkelä, Tuukka Toivonen, Piritta Setälä, Hetti Kirves, Miretta Tommila, Pamela Toivonen, Simo Tukia, Jouni Nurmi   +9 more
wiley   +1 more source

Research progress on the clinical application of esketamine

Zhongguo linchuang yanjiu
Esketamine is the S-enantiomer of racemic ketamine, which has a similar pharmacological mechanism to ketamine. Esketamine has the advantages of fast onset, fast metabolism, little impact on circulatory and respiratory functions, and strong sedative and ...
JIANG Lele, DU Xiaoxuan
doaj   +1 more source

Oral esketamine for difficult-to-treat depression [PDF]

Depressive disorder is a common mental health condition that causes significant personal suffering, functional limitations, loss of productivity, and high healthcare costs.
Smith-Apeldoorn, Sanne
core   +1 more source

Opioid‐Free Versus Opioid‐Based Anesthesia in Laparoscopic Surgery: Systematic Review and Meta‐Analysis Across Multiple Perioperative Outcomes

Anesthesiology Research and Practice, Volume 2026, Issue 1, 2026.
Background Opioid‐free anesthesia (OFA) has been proposed as a strategy to reduce opioid exposure and opioid‐related adverse events in laparoscopic surgery. However, evidence from randomized trials remains heterogeneous regarding pain control, postoperative nausea and vomiting (PONV), and opioid consumption. Methods We performed a systematic review and
Carlos Darcy Alves Bersot, Peterson Vinicius Elias da Silva, Matheus Reis Rocha Melo Barros, Ana Carolina da Silva Louzada, Daniel Barros Derito, Brenda Dutra Coutinho, Vitor Alves Felippe, Renato Faria da Gama, Luis Fernando Lemos Aguiar da Silva, Lucas Ferreira Gomes Pereira, José Eduardo Guimarães Pereira, Fabrizio Monaco   +11 more
wiley   +1 more source

Pharmacokinetics and Safety of Esketamine in Chinese Patients Undergoing Painless Gastroscopy in Comparison with Ketamine: A Randomized, Open-Label Clinical Study

Drug Design, Development and Therapy, 2019
Jing Wang,1,2,* Jie Huang,1,3,* Shuang Yang,1,3 Chang Cui,1,3 Ling Ye,1,3 Sai-ying Wang,4 Guo-ping Yang,1,3 Qi Pei1,2 1Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, People’s Republic
Wang J, Huang J, Yang S, Cui C, Ye L, Wang S, Yang G, Pei Q   +7 more
doaj  

Successful Surgical Repair of Ventricular Septal Defect in a Child With Ocular Myasthenia Gravis and History of Myeloid Sarcoma Post‐HSCT: A Multidisciplinary Approach

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT A 3 year‐old child with ocular myasthenia gravis and a history of hematopoietic stem cell transplantation underwent successful ventricular septal defect repair through carefully coordinated multidisciplinary management. The tailored anesthetic approach and infection‐control strategy enabled smooth recovery without neuromuscular or immunologic ...
Shuhan Rong, Wanyu Xu, Xin Li
wiley   +1 more source

Postoperative esketamine improves ventilation after video-assisted thoracoscopic lung resection: A double-blinded randomized controlled trial

Heliyon
Background: Pain management after lung resection plays a crucial role in reducing postoperative pulmonary complications (PPCs). This study aimed to examine the effect of postoperative esketamine infusion as an adjunct to opioid analgesia on ventilation ...
Mengyue Fu, Rui Xu, Guizhen Chen, Xuemei Zheng, Bin Shu, He Huang, Guangyou Duan, Yuanjing Chen   +7 more
doaj   +1 more source