Results 11 to 20 of about 15,738 (196)

Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia. [PDF]

PLoS ONE, 2018
The discovery of new treatments that prevent or treat preeclampsia would be a major advance. Antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG) are secreted in excess from the placenta, causing hypertension ...
Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Sally Beard, Ping Cannon, Roxanne Hastie, Tuong V Nguyen, Natalie K Binder, Stephen Tong, Natalie J Hannan   +8 more
doaj   +1 more source

Esomeprazole and apixaban pharmacokinetic interactions in healthy rats

Heliyon, 2022
Esomeprazole is used in various clinical settings where a decrease in gastric acid production is desired since it is a proton pump inhibitor. Apixaban, an anticoagulant, is used to reduce the risk of stroke in patients with certain cardiovascular ...
Ali Jaber, Israa Al-Ani, Mohammad Hailat, Enas Daoud, Anmar Abu-Rumman, Zainab Zakaraya, Bashar J.M. Majeed, Osaid Al Meanazel, Wael Abu Dayyih   +8 more
doaj   +1 more source

Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study [PDF]

, 2011
Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication.
Beecher, Belafsky, Birring, Blondeau, Chang, Corley, Decalmer, DeVault, Dial, Eccles, Eherer, Everett, Faruqi, FitzGerald, Gilard, Gulmez, Hemmink, Herzig, Ing, Irwin, Irwin, Irwin, Irwin, Juurlink, Laheij, Lenglinger, Mastronarde, Morice, Morice, Morice, Morice, Noordzij, Pratter, Rostami-Hodjegan, Shaheen, Vaezi, Vertigan, Wager, Waring, Wo, Yang, Yearsley   +41 more
core   +1 more source

Pharmacokinetics and Anti-Gastric Ulceration Activity of Oral Administration of Aceclofenac and Esomeprazole in Rats

Pharmaceutics, 2018
This study examined the effects of esomeprazole on aceclofenac pharmacokinetics and gastrointestinal complications in rats. Aceclofenac alone, or in combination with esomeprazole, was orally administered to male Sprague-Dawley rats. Plasma concentrations
Tae Hwan Kim, Subindra Kazi Thapa, Da Young Lee, Seung Eun Chung, Jun Young Lim, Hyeon Myeong Jeong, Chang Ho Song, Youn-Woong Choi, Sang-Min Cho, Kyu-Yeol Nam, Won-Ho Kang, Soyoung Shin, Beom Soo Shin   +12 more
doaj   +1 more source

Effect of esomeprazole with and without a probiotic on fecal dysbiosis, intestinal inflammation, and fecal short‐chain fatty acid concentrations in healthy dogs

Journal of Veterinary Internal Medicine, 2023
Background Proton pump inhibitors can cause diarrhea and a transient increase in fecal dysbiosis index in dogs. It is unknown if concurrent probiotic administration mitigates these effects.
Rae McAtee, Sarah M. Schmid, M. Katherine Tolbert, Scott Hetzel, Jan S. Suchodolski, Jessica C. Pritchard   +5 more
doaj   +1 more source

Pharmacokinetics of esomeprazole in goats (Capra aegagrus hircus) after intravenous and subcutaneous administration

Frontiers in Veterinary Science, 2022
BackgroundStressed and hospitalized goats are at risk of developing abomasal (gastric) ulceration, but there is a paucity of pharmacokinetic studies for proton pump inhibiting drugs, such as, esomeprazole in goats.ObjectivesThe objectives for this study ...
Rachel Fladung, Joe S. Smith, Joe S. Smith, Melissa T. Hines, Windy Michelle Soto-Gonzalez, Bryanna Fayne, Rebecca R. Rahn, Olivia Grace Escher, Lainey Harvill, Joan Bergman, Jessica D. Garcia, Amanda Jo Kreuder, Sherry Cox   +12 more
doaj   +1 more source

In Vitro Evaluation of Eslicarbazepine Delivery via Enteral Feeding Tubes [PDF]

, 2017
Purpose: The feasibility of preparing an eslicarbazepine acetate suspension using Aptiom tablets for administration via enteral feeding tubes was evaluated.
Dave, Vivek S, Hughes, Susan, Reindel, Kristin, Zhao, Fang   +3 more
core   +2 more sources

Prevalence of Gastroesophageal Reflux in Cats During Anesthesia and Effect of Omeprazole on Gastric pH. [PDF]

, 2017
BackgroundGastroesophageal reflux (GER) is poorly characterized in anesthetized cats, but can cause aspiration pneumonia, esophagitis, and esophageal stricture formation.ObjectiveTo determine whether pre-anesthetic orally administered omeprazole ...
Belafsky, PC, Della Maggiore, A, Fulton, A, Garcia, RS, Marks, SL, Osborn, JM, Pierce, T, Pypendop, BH, Walker, VJ   +8 more
core   +3 more sources

Proton pump inhibitors (PPIs) impact on tumour cell survival, metastatic potential and chemotherapy resistance, and affect expression of resistance-relevant miRNAs in esophageal cancer [PDF]

, 2014
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Borchardt, C, Burgers, A, Haier, Jorg, Hummel, Richard, Hussey, Damian James, Lidner, K, Schopp, M, Stock, C   +7 more
core   +1 more source

Prediction of Drug Stability Using Deep Learning Approach: Case Study of Esomeprazole 40 mg Freeze-Dried Powder for Solution

Pharmaceutics, 2021
A critical step in the production of Esomeprazole powder for solution is a period between the filling process and lyophilization, where all vials, partially closed, are completely exposed to environmental influences.
Jovana Ajdarić, Svetlana Ibrić, Aleksandar Pavlović, Ljubiša Ignjatović, Branka Ivković   +4 more
doaj   +1 more source