Results 31 to 40 of about 15,738 (196)
Virtual bioequivalence for achlorhydric subjects: The use of PBPK modelling to assess the formulation-dependent effect of achlorhydria [PDF]
, 2017 Majority of bioequivalence studies are conducted in healthy volunteers. It has been argued that bioequivalence may not necessarily hold true in relevant patient populations due to a variety of reasons which affect one formulation more than the other for ...
Darwich Adam S. +4 more
core +1 more source
CYP2C19 Genotype is Associated with Citalopram Treatment Outcomes in a Real‐World Setting
Clinical Pharmacology &Therapeutics, EarlyView.CYP2C19 metabolizes various selective serotonin reuptake inhibitors (SSRIs) and genetic CYP2C19 variants are associated with SSRI tolerability and response. Yet, whether CYP2C19 variability also impacts citalopram response remained unclear. We here evaluated associations between CYP2C19 genotypes and citalopram prescription data of 11,079 patients from
Yoomi Park +2 more
wiley +1 more source
Gender Differences in the Effects of Esomeprazole on Ethanol-Induced Acute Gastric Injury in Mice
Frontiers in Bioscience-LandmarkBackground: A gastric ulcer is a common gastrointestinal disorder, particularly associated with alcohol abuse, leading to acute ulcers.
Zhi-hui Yi +8 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Carotid artery stenting (CAS) is an effective treatment for carotid stenosis. Proton‐pump inhibitors (PPIs) are commonly prescribed in the general population. However, the impact of PPI use on outcomes following CAS remains unknown. This study investigated the impact of PPI use on CAS using a retrospective, matched‐cohort analysis from the ...
Chia‐En Wong +7 more
wiley +1 more source
Esophageal impedance baselines in infants before and after placebo and proton pump inhibitor therapy [PDF]
, 2012 Author version made available in accordance with the publisher's policy.ABSTRACT Background Esophageal impedance monitoring records changes in conductivity. During esophageal rest impedance baseline values may represent mucosal integrity.
Benninga, Marc Alexander +5 more
core +8 more sources
Esomeprazole’s Antifibrotic Effects on Rats With Epidural Fibrosis
Global Spine JournalStudy Design Rat subjects were randomly assigned to control, local, and systemic esomeprazole groups (n = 4-6 per group). Objective Excessive scar formation after laminectomy can cause nerve entrapment and postoperative pain and discomfort.
Ali Borekci MD +4 more
doaj +1 more source
Acta Paediatrica, EarlyView.ABSTRACT Aim The aim was to observe the methods used for off‐label manipulation of medication on Norwegian paediatric wards. Methods This prospective observational study used a digital form to collect information on how medicine was manipulated on five paediatric wards in four university and local hospitals, from October 2023 to May 2024.
Randi Hamre Svendsen +4 more
wiley +1 more source
Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory. [PDF]
, 2019 Proton-pump inhibitors, PPIs, are considered effective therapy for stomach acid suppression due to their irreversible inhibition of the hydrogen/potassium pump in the gastric parietal cells. They are widely prescribed and are considered safe for over-the-
Abagyan, Ruben +4 more
core +1 more source
Correlation between oesophageal acid exposure and dyspeptic symptoms in patients with nonerosive reflux disease. [PDF]
, 2008 Oesophageal acidification induces dyspeptic symptoms in healthy individuals. This study aimed to evaluate the correlation between oesophageal acid exposure and dyspeptic symptoms in patients with nonerosive reflux disease. METHODS: A total of 68 patients
APREA, GIOVANNI +8 more
core +1 more source
Alimentary Pharmacology &Therapeutics, EarlyView.This multicenter, observational study reveals distinct alterations in the microbial spectrum of spontaneous bacterial peritonitis (SBP) associated with proton pump inhibitor use. These results are especially relevant for guiding empiric antibiotic therapy of SBP.
Philip Kitchen +13 more
wiley +1 more source