Results 91 to 100 of about 337,805 (303)

Assessment of the Diagnostic Performance of Endoscopic Ultrasonography After Conventional Endoscopy for the Evaluation of Esophageal Squamous Cell Carcinoma Invasion Depth

JAMA Network Open, 2021
Key Points Question Is the performance of endoscopic ultrasonography after conventional endoscopy associated with improvements in diagnosing the invasion depth of esophageal squamous cell carcinoma?
R. Ishihara, J. Mizusawa, R. Kushima, N. Matsuura, T. Yano, T. Kataoka, H. Fukuda, N. Hanaoka, Toshiyuki Yoshio, S. Abe, Yoshinobu Yamamoto, S. Nagata, H. Ono, Masashi Tamaoki, Naohiro Yoshida, K. Takizawa, M. Muto   +16 more
semanticscholar   +1 more source

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31‐Mediated Degradation of CBX8

Advanced Science, EarlyView.
This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng, Zijie Ye, Manna Zheng, Jing Pan, Tianbao Tan, Jiliang Yang, Jiahao Li, Zhang Zhao, Tianzhu Long, Liyu Zhang, Gautam Sethi, Tianyou Yang, Chao Hu, Yan Zou   +13 more
wiley   +1 more source

Automatic detection of squamous cell carcinoma metastasis in esophageal lymph nodes using semantic segmentation

Clinical and Translational Medicine, 2020
Esophageal squamous cell carcinoma (ESCC) is more prevalent than esophageal adenocarcinoma in Asia, especially in China, where more than half of ESCC cases occur worldwide.
Yi Pan, Zhuo Sun, Wenmiao Wang, Zhaoyang Yang, Jia Jia, Xiaolong Feng, Yaxi Wang, Qing Fang, Jiangtao Li, Hongtian Dai, Calvin Ku, Shuhao Wang, Cancheng Liu, Liyan Xue, Ning Lyu, Shuangmei Zou   +15 more
doaj   +1 more source

Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma

Nature Communications, 2020
Epigenetic landscapes can shape physiologic and disease phenotypes. We used integrative, high resolution multi-omics methods to delineate the methylome landscape and characterize the oncogenic drivers of esophageal squamous cell carcinoma (ESCC).
W. Cao, Hayan Lee, Wei Wu, Aubhishek Zaman, S. McCorkle, M. Yan, Justin Chen, Q. Xing, N. Sinnott-Armstrong, Hongen Xu, M. R. Sailani, Wenxue Tang, Yuanbo Cui, Jia Liu, H. Guan, P. Lv, Xiaoyan Sun, Lei Sun, P. Han, Y. Lou, Jing Chang, Jinwu Wang, Yuchi Gao, Jiancheng Guo, G. Schenk, A. Shain, F. Biddle, E. Collisson, Michael Snyder, T. Bivona   +29 more
semanticscholar   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Nipped-B-like Protein Sensitizes Esophageal Squamous Cell Carcinoma Cells to Cisplatin via Upregulation of PUMA

Technology in Cancer Research & Treatment, 2020
Nipped-B-like protein plays a pivotal role as a cohesin loading factor in the segregation of chromosomes when cells divide. Accumulating evidence indicates that alterations of this protein are involved in human carcinogenesis, especially in the ...
Shengjie Zhang PhD, Yun Zhou BM, Qinchuan Wang MD, PhD, Kristine Donahue PhD, Jianguo Feng MMed, Yinli Yao MMed, Aiping Chen PhD, Xia Li PhD, Lianlian Hong PhD   +8 more
doaj   +1 more source

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

Expression and clinical significance of phosphorylated FGFR1Y654 in esophageal squamous cell carcinoma

陆军军医大学学报
Objective To explore the relationship between p-FGFR1Y654 expression and clinical pathological characteristics of esophageal squamous cell carcinoma patients and its prognostic value.
DU Dan, DU Dan, LI Jing, LUO Hong
doaj   +1 more source