Results 71 to 80 of about 124,971 (293)

The significance of CD4+ and CD8+ T lymphocyte infiltration in esophageal squamous cell carcinoma

Indian Journal of Pathology and Microbiology
Purpose: To investigate the relationship between the abundance of CD4+ and CD8+ T cells in the tumor microenvironment and the prognosis of patients with esophageal squamous cell carcinoma, and to analyze their correlation and explore its clinical value ...
Jiang Y. Zhao, Xiaojun Pang, Jiao Peng, Jingtao Liu, Qiang Deng, Shunhai Jian   +5 more
doaj   +1 more source

Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo. [PDF]

, 2015
BACKGROUND: Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency.
Alder, Hansjuerg, Chen, Hongping, Croce, Carlo M., Di Leva, Gianpiero, Fadda, Paolo, Farber, John L., Fong, Louise, Garofalo, Michela, Jiang, Yubao, Middleton, Justin, Naidu, Srivatsava, Selmi, Tommaso, Smalley, Karl J., Taccioli, Cristian, Tagliazucchi, Guidantonio Malagoli   +14 more
core   +1 more source

Non-coding RNAs in saliva: emerging biomarkers for molecular diagnostics. [PDF]

, 2015
Saliva is a complex body fluid that comprises secretions from the major and minor salivary glands, which are extensively supplied by blood. Therefore, molecules such as proteins, DNA, RNA, etc., present in plasma could be also present in saliva.
Majem, Blanca, Reventós, Jaume, Rigau, Marina, Wong, David T   +3 more
core   +4 more sources

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Nipped-B-like Protein Sensitizes Esophageal Squamous Cell Carcinoma Cells to Cisplatin via Upregulation of PUMA

Technology in Cancer Research & Treatment, 2020
Nipped-B-like protein plays a pivotal role as a cohesin loading factor in the segregation of chromosomes when cells divide. Accumulating evidence indicates that alterations of this protein are involved in human carcinogenesis, especially in the ...
Shengjie Zhang PhD, Yun Zhou BM, Qinchuan Wang MD, PhD, Kristine Donahue PhD, Jianguo Feng MMed, Yinli Yao MMed, Aiping Chen PhD, Xia Li PhD, Lianlian Hong PhD   +8 more
doaj   +1 more source

Long-term survival after definitive proton beam therapy for oligorecurrent esophageal squamous cell carcinoma: a case report

Journal of Medical Case Reports, 2022
Background Radical esophagectomy for esophageal squamous cell carcinoma has improved survival, but the rate of recurrence is high. Patients of recurrent esophageal squamous cell carcinoma after failure of chemotherapy have a poor prognosis.
Yojiro Ishikawa, Motohisa Suzuki, Hisashi Yamaguchi, Ichiro Seto, Masanori Machida, Yoshiaki Takagawa, Keiichi Jingu, Yasuyuki Kikuchi, Masao Murakami   +8 more
doaj   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Automatic detection of squamous cell carcinoma metastasis in esophageal lymph nodes using semantic segmentation

Clinical and Translational Medicine, 2020
Esophageal squamous cell carcinoma (ESCC) is more prevalent than esophageal adenocarcinoma in Asia, especially in China, where more than half of ESCC cases occur worldwide.
Yi Pan, Zhuo Sun, Wenmiao Wang, Zhaoyang Yang, Jia Jia, Xiaolong Feng, Yaxi Wang, Qing Fang, Jiangtao Li, Hongtian Dai, Calvin Ku, Shuhao Wang, Cancheng Liu, Liyan Xue, Ning Lyu, Shuangmei Zou   +15 more
doaj   +1 more source

miRNAs link metabolic reprogramming to oncogenesis [PDF]

, 2013
The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M, Iliopoulos, D, Polytarchou, C   +2 more
core   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source