Results 51 to 60 of about 124,971 (293)

Impact of Radiotherapy, Chemotherapy and Surgery in Multimodal Treatment of Locally Advanced Esophageal Cancer [PDF]

, 2011
Objectives: It was the aim of this study to assess our institutional experience with definitive chemoradiation (CRT) versus induction chemotherapy followed by CRT with or without surgery (C-CRT/S) in esophageal cancer.
Adams R, Annina Lemminger, Bedenne L, Berger B, Bernhard Berger, Claus Belka, Cooper JS, Delcambre C, Denham JW, Herskovic A, Katharina Stahlberg, Malthaner RA, Martin Bleif, Michael Bamberg, Minsky BD, Mizumoto M, Rades D, Sarraf M, Seung SK, Shi XH, Stahl M, Tepper J, Wolf M, Zhang Z   +23 more
core   +1 more source

Esophageal Squamous Cell Papilloma, Suspected of Squamous Cell Carcinoma.

Internal Medicine, 1993
A 46-year-old male without any subjective complaints was diagnosed by radiography as having one polypoid lesion at the distal esophagus. Endoscopy indicated a semipedunculated polyp about 1 cm in size, the specimens of which included atypical cells with a high N/C ratio in the submucosa.
T, Yuki, S, Kawano, T, Ogihara, N, Sato, S, Okamoto, K, Sato, T, Kamada, N, Takada, J, Furukawa, J, Okamura   +9 more
openaire   +3 more sources

Esophageal Squamous Cell Carcinoma With Colonic Metastases

ACG Case Reports Journal, 2020
ABSTRACT Esophageal squamous cell carcinoma (ESCC) is recognized as one of the most lethal malignancies worldwide. The disease's tendency to quickly metastasize precludes many patients from receiving curative therapy. The most common sites of distal metastases include the liver, lungs, bones, and brain.
Wiseman, Daniel, Ferri, Lorenzo, Lakatos, Peter L., Fiset, Pierre-Olivier, Bessissow, Talat   +4 more
openaire   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Gene therapy for esophageal squamous cell carcinoma [PDF]

Frontiers in Bioscience, 2008
Despite improvement of surgical treatment and application of multi-modality therapies to advanced esophageal cancer, the prognosis is extremely poor in patients with T4 tumors. Based on the genetic background of esophageal cancer, we have developed various gene therapy strategies against human esophageal cancer cells.
Hideaki, Shimada, Takenori, Ochiai
openaire   +2 more sources

TP53 Mutations in Esophageal Squamous Cell Carcinoma

Frontiers in Bioscience-Landmark, 2023
The occurrence and development of esophageal cancer involve multiple genetic abnormalities that contribute to the malignant transformation of esophageal epithelial cells, followed by invasion and metastasis, leading to a poor outcome. Esophageal squamous cell carcinoma (ESCC) is the predominant histological subtype of esophageal malignancy in East Asia,
Leqi Zhong, Hongmu Li, Wuguang Chang, Yong Ao, Zhesheng Wen, Youfang Chen   +5 more
openaire   +3 more sources

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

PTK7 is a novel oncogenic target for esophageal squamous cell carcinoma

World Journal of Surgical Oncology, 2017
Background Overexpression of PTK7 has been found in multiple cancers and has been proposed to serve as a prognostic marker for intrahepatic cholangiocarcinoma. Its role in esophageal cancer, however, remains to be clarified.
Kang Liu, Guiqin Song, Xuqian Zhang, Qiujiang Li, Yunxia Zhao, Yuchuan Zhou, Rong Xiong, Xin Hu, Zhirong Tang, Gang Feng   +9 more
doaj   +1 more source

Advanced head and neck cancer: Long-term results of chemo-radiotherapy, complications and induction of second malignancies [PDF]

, 2001
Background: Chemo-radiotherapy is superior to radiotherapy alone in the treatment of advanced, inoperable head and neck cancer. The long-term treatment results, the induction of second malignant tumors, and other long-term toxicities are not well defined.
Aydemir, Ü., Hartenstein, R., Munker, Reinhold, Pohlmann, H., Purmale, L., Reitmeier, M., Schorer, H.   +6 more
core   +1 more source

Esophageal adenosquamous carcinoma mimicking acantholytic squamous cell carcinoma

Oncology Letters, 2017
Herein is described a unique case of esophageal cancer mimicking acantholytic squamous cell carcinoma (SCC). The patient succumbed to the disease within one month of diagnosis. Autopsy revealed a 10-cm esophageal tumor, characterized by prominent acantholysis-like areas composed of discohesive cancer cells, along with nested growth of SCC.
Susumu, Matsukuma, Oh, Takahashi, Yoshitaka, Utsumi, Masaki, Tsuda, Kosuke, Miyai, Kenji, Okada, Hiroaki, Takeo   +6 more
openaire   +3 more sources