Results 31 to 40 of about 337,805 (303)

Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma

JAMA Surgery, 2021
Key Points Question Does treatment with neoadjuvant chemoradiotherapy plus surgery improve the long-term survival of patients with locally advanced esophageal squamous cell carcinoma (ESCC) compared with surgery alone?
Han Yang, Hui Liu, Yu-ping Chen, Chengchu Zhu, W. Fang, Zhentao Yu, W. Mao, J. Xiang, Yongtao Han, Zhijian Chen, Haihua Yang, Jia-ming Wang, Q. Pang, Xiao Zheng, Huan-jun Yang, Tao Li, Xu Zhang, Qun Li, Gen-jie Wang, Baofu Chen, T. Mao, M. Kong, Xufeng Guo, Ting Lin, Mengzhong Liu, Jianhua Fu   +25 more
semanticscholar   +1 more source

Integrated multi-omics profiling yields a clinically relevant molecular classification for esophageal squamous cell carcinoma.

Cancer Cell, 2022
Integrated molecular analysis of human cancer has yielded molecular classification for precise management of cancer patients. Here, we analyzed the whole genomic, epigenomic, transcriptomic, and proteomic data of 155 esophageal squamous cell carcinomas ...
Zhihua Liu, Yahui Zhao, Pengzhou Kong, Yuhao Liu, Jing Huang, Enwei Xu, Wenqing Wei, Guangyu Li, Xiaolong Cheng, L. Xue, Yi Li, Hongyan Chen, Shuqing Wei, R. Sun, H. Cui, Yongsheng Meng, Meilin Liu, Yang Li, R. Feng, Xiao Yu, R. Zhu, Yenan Wu, Lei Li, Bin Yang, Yanchun Ma, Jiawei Wang, Wenjie Zhu, Dong Deng, Y. Xi, Fang Wang, Hongyi Li, Shi-ping Guo, Xiaofei Zhuang, Xiaoyue Wang, Y. Jiao, Yongping Cui, Q. Zhan   +36 more
semanticscholar   +1 more source

Downregulation of Ubiquitin Inhibits the Aggressive Phenotypes of Esophageal Squamous Cell Carcinoma

Technology in Cancer Research & Treatment, 2020
Purpose: Esophageal cancer is one of the most common malignancies worldwide. Ubiquitin-dependent degradation of regulatory proteins reportedly plays a central role in diverse cellular processes.
Yi Gao MD, Wei Mo MD, Li Zhong MD, Huimin Jia MD, Yiren Xu BA, Ji Zhang BA, Xiaohui Xu MD, Weidong Shen PhD, Fangjun Wang PhD, Tengfei Li MD, Pengfei Liu PhD, Shuyu Zhang PhD   +11 more
doaj   +1 more source

Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment

Nature Communications, 2021
The tumor microenvironment is a highly complex ecosystem of diverse cell types, which shape cancer biology and impact the responsiveness to therapy. Here, we analyze the microenvironment of esophageal squamous cell carcinoma (ESCC) using single-cell ...
Huy Q. Dinh, Feng Pan, Gen-jie Wang, Qingke Huang, Claire E. Olingy, Zhiyong Wu, Shao-hong Wang, Xin Xu, Xiue Xu, Jianzhong He, Qian Yang, S. Orsulic, Marcela A. Haro, Li-yan Li, Guo-wei Huang, J. Breunig, H. Koeffler, C. Hedrick, Li-Yan Xu, D. Lin, E. Li   +20 more
semanticscholar   +1 more source

NOTCH and Esophageal Squamous Cell Carcinoma

, 2020
Esophageal squamous cell carcinoma (ESCC) is a deadly disease that requires extensive research on its mechanisms, prevention, and therapy. Recent studies have shown that NOTCH mutations are commonly seen in human ESCC. This chapter summarizes our current understanding of the NOTCH pathway in normal esophagus and in ESCC.
Yong, Li, Yahui, Li, Xiaoxin, Chen
openaire   +3 more sources

Morbidity and Mortality of Patients Who Underwent Minimally Invasive Esophagectomy After Neoadjuvant Chemoradiotherapy vs Neoadjuvant Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma

JAMA Surgery, 2021
Key Points Question Is there any difference in the safety of neoadjuvant chemoradiotherapy (nCRT) followed by minimally invasive esophagectomy (MIE) for locally advanced esophageal squamous cell carcinoma (ESCC) compared with that of neoadjuvant ...
Hao Wang, Han Tang, Yong Fang, L. Tan, Jun Yin, Yaxing Shen, Z. Zeng, Jiangyi Zhu, Yingyong Hou, M. Du, Jia Jiao, Hongjing Jiang, L. Gong, Zhigang Li, Jun Liu, D. Xie, Wenfeng Li, C. Lian, Qiang Zhao, Chun Chen, B. Zheng, Y. Liao, Kuo Li, Hecheng Li, Han-Yun Wu, L. Dai, Ke-Neng Chen   +26 more
semanticscholar   +1 more source

Preliminary evaluation for Bit1 as a potential biomarker for squamous cell carcinoma and adenocarcinoma of esophagus

Tumor Biology, 2017
Mounting evidence has demonstrated that Bit1 has been investigated as an etiological factor for certain cancers, including esophageal squamous cell carcinoma reported in our previous study, but data regarding possible roles of Bit1 in esophageal squamous
Jing Chen, Hongtao Liu, Pan Gao, Yiran Hui, Zhenzhen Yang, Xiaqing Zhang, Peirong Xu, Fang Tian, Tianli Fan   +8 more
doaj   +1 more source

Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment

Nature Communications, 2020
Cancer immunotherapy has revolutionized cancer treatment, and it relies heavily on the comprehensive understanding of the immune landscape of the tumor microenvironment (TME).
Yingxia Zheng, Zheyi Chen, Yichao Han, Li Han, Xin Zou, Bingqian Zhou, Rui Hu, Jie Hao, Shihao Bai, Hai-bo Xiao, W. Li, Alex Bueker, Yanhui Ma, Guo-hua Xie, Junyao Yang, Shiyu Chen, Hecheng Li, Jian Cao, Lisong Shen   +18 more
semanticscholar   +1 more source

Effectiveness of Immune Checkpoint Inhibitors in Patients With Advanced Esophageal Squamous Cell Carcinoma

JAMA Oncology, 2022
Key Points Question Does immunotherapy confer a survival benefit for patients with advanced esophageal squamous cell carcinoma and low expression of programmed death ligand 1?
D. Yap, A. Leone, N.Z.H. Wong, Joseph J. Zhao, J. Tey, R. Sundar, F. Pietrantonio   +6 more
semanticscholar   +1 more source

Semaphorin 3F Serves as a Tumor Suppressor in Esophageal Squamous Cell Carcinoma and is Associated With Lymph Node Metastasis in Disease Progression

Technology in Cancer Research & Treatment, 2020
Background: Esophageal squamous cell carcinoma is one of the leading aggressive malignancies with high mortality. Semaphorin 3F has been reported to be involved in lymphangiogenesis by interacting the vascular endothelial growth factor C/neuropilin 2 ...
Zhen Xie MD, Tianyue Li MD, Bingtao Huang MM, Shuai Liu MM, Lianguo Zhang MM, Qingguang Zhang MD   +5 more
doaj   +1 more source