Results 41 to 50 of about 79,234 (256)

Expression and Regulatory Network Analysis of MiR-139-3p, a New Potential Serum Biomarker for Esophageal Squamous Cell Carcinoma Based on Bioinformatics Analysis

Technology in Cancer Research & Treatment, 2020
Background: In recent studies, microRNAs have been demonstrated as stable detectable biomarkers in blood for cancer. In addition, computer-aided biomarker discovery has now become an attractive paradigm for precision diagnosis. Methods: In this study, we
Yonghong Wang MM, Qimei Fang BM, Liru Tian BM, Zhongzhen Yuan MM, Lizhen Tian BM, Zhongli Zhou BM   +5 more
doaj   +1 more source

Long-term survival after pulmonary metastasectomy in patients with esophageal squamous cell carcinoma with lung metastasis

Journal of Cardiothoracic Surgery, 2022
Objectives Esophageal squamous cell carcinoma with pulmonary metastasis has a poor prognosis, and the only treatment modality is systemic therapy such as chemotherapy.
Chien-Ming Lo, Kai-Hao Chuang, Hsing-Hua Lai, Yu Chen, Li-Chun Chen, Hung-I Lu, Yen-Hao Chen, Shau-Hsuan Li   +7 more
doaj   +1 more source

Case report: A case of rectal metastatic squamous cell carcinoma from the esophagus

Frontiers in Oncology, 2023
Esophageal cancer is prone to distant metastasis, and the prognosis is very poor; the occurrence of intestinal metastasis is extremely rare, with atypical clinical manifestations.
Junni Chen, Shuai Zhang, Jiawei Chen
doaj   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

MicroRNAs in esophageal squamous cell carcinoma

Epigenomics
Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy requiring improved early diagnosis and prognostic assessment. MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression, have emerged as promising biomarkers for ESCC. We conducted a comprehensive literature search in PubMed for studies published up to 2025. While miRNA
Liu, Qi-Wei, Liu, Zi-Qin, Wang, Ming, Qi, Yi-Jun   +3 more
openaire   +3 more sources

TP53 Mutations in Esophageal Squamous Cell Carcinoma

Frontiers in Bioscience-Landmark, 2023
The occurrence and development of esophageal cancer involve multiple genetic abnormalities that contribute to the malignant transformation of esophageal epithelial cells, followed by invasion and metastasis, leading to a poor outcome. Esophageal squamous cell carcinoma (ESCC) is the predominant histological subtype of esophageal malignancy in East Asia,
Leqi Zhong, Hongmu Li, Wuguang Chang, Yong Ao, Zhesheng Wen, Youfang Chen   +5 more
openaire   +3 more sources

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

PTK7 is a novel oncogenic target for esophageal squamous cell carcinoma

World Journal of Surgical Oncology, 2017
Background Overexpression of PTK7 has been found in multiple cancers and has been proposed to serve as a prognostic marker for intrahepatic cholangiocarcinoma. Its role in esophageal cancer, however, remains to be clarified.
Kang Liu, Guiqin Song, Xuqian Zhang, Qiujiang Li, Yunxia Zhao, Yuchuan Zhou, Rong Xiong, Xin Hu, Zhirong Tang, Gang Feng   +9 more
doaj   +1 more source

Etiology and chemoprevention of esophageal squamous cell carcinoma [PDF]

Carcinogenesis, 2001
Squamous cell carcinoma (SCC) of the human esophagus has a multifactorial etiology involving several environmental and/or genetic factors. Current modalities of therapy for this disease offer poor survival and cure rates. Although a number of approaches could be undertaken to reduce the occurrence of esophageal SCC, including changes in lifestyle and ...
G D, Stoner, A, Gupta
openaire   +2 more sources

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source