Results 21 to 30 of about 337,805 (303)

Chemoprevention of esophageal squamous cell carcinoma [PDF]

Toxicology and Applied Pharmacology, 2007
Esophageal squamous cell carcinoma (SCC) is responsible for approximately one-sixth of all cancer-related mortality worldwide. This malignancy has a multifactorial etiology involving several environmental, dietary and genetic factors. Since esophageal cancer has often metastasized at the time of diagnosis, current treatment modalities offer poor ...
Gary D, Stoner, Li-Shu, Wang, Tong, Chen
openaire   +2 more sources

Characteristic and Interplay of Esophageal Microbiota in Esophageal Squamous Cell Carcinoma [PDF]

BMC Cancer, 2021
Abstract Background: Esophageal squamous cell carcinoma(ESCC) is severe cancer in the world. The role of esophageal microbiota for ESCC is still uncertain. In the current study, 120 paired tissues from ESCC patients were collected, and 16s rRNA sequencing was performed to explore the esophageal microbiota.
Zheng Lin, Wenqing Rao, Zhisheng Xiang, Qiaoyan Zeng, Shuang Liu, Kaili Yu, Jinsong Zhou, Jianwen Wang, Weilin Chen, Yuanmei Chen, Xiane Peng, Zhijian Hu   +11 more
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Mechanisms of radiotherapy resistance and radiosensitization strategies for esophageal squamous cell carcinoma

Molecular Cancer, 2023
Esophageal squamous cell carcinoma (ESCC) is the sixth most common cause of cancer-related mortality worldwide, with more than half of them occurred in China. Radiotherapy (RT) has been widely used for treating ESCC. However, radiation-induced DNA damage
Lin An, Mingyang Li, Qingge Jia
semanticscholar   +1 more source

Immunotherapy for Esophageal Squamous Cell Carcinoma [PDF]

Current Oncology Reports, 2017
Esophageal squamous cell carcinoma have been frustrating to treat, with slow progress made on extending survival. Immunotherapy targeting immune checkpoints, T cells, and infiltrating lymphocytes has shown promise in early studies. The efficacy of pembrolizumab and nivolumab is encouraging. Anti-chemokine receptors and oncolytic viruses are also making
Kojima, Takashi, Doi, Toshihiko
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Characterization of Esophageal Microbiota in Patients With Esophagitis and Esophageal Squamous Cell Carcinoma [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
Microbial imbalances have been well elucidated in esophageal adenocarcinoma. However, few studies address the microbiota in esophageal squamous cell carcinoma (ESCC) and esophagitis (ES). We aimed to explore the association of esophageal microbiota with these patients.
Jiang Zongdan, jun wang, ziyang shen, zhenyu zhang, shukui Wang   +4 more
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How we treat esophageal squamous cell carcinoma

ESMO Open, 2023
Esophageal squamous cell carcinoma (ESCC) poses a major challenge for clinicians as the prognosis is poor and treatment options are limited. However, recent advances in immunotherapy have significantly changed the treatment algorithm of ESCC.
H. Puhr, G. Prager, A. Ilhan-Mutlu
semanticscholar   +1 more source

Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis

Nature Communications, 2021
Esophageal squamous-cell carcinoma (ESCC), one of the most prevalent and lethal malignant disease, has a complex but unknown tumor ecosystem. Here, we investigate the composition of ESCC tumors based on 208,659 single-cell transcriptomes derived from 60 ...
Xiannian Zhang, Linna Peng, Yingying Luo, Shaosen Zhang, Yang Pu, Yamei Chen, Wenjia Guo, Jiacheng Yao, Mingming Shao, W. Fan, Qionghua Cui, Yiyi Xi, Yanxia Sun, Xia Niu, Xuan Zhao, Liping Chen, Yuqian Wang, Yachen Liu, Xinyu Yang, Chengcheng Wang, Ce-jun Zhong, W. Tan, Jianbin Wang, Chen Wu, D. Lin   +24 more
semanticscholar   +1 more source

N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis

Nature Communications, 2022
Mis-regulated RNA modifications promote the processing and translation of oncogenic mRNAs to facilitate cancer progression, while the molecular mechanisms remain unclear. Here we reveal that tRNA m7G methyltransferase complex proteins METTL1 and WDR4 are
Hui Han, Chunlong Yang, Jieyi Ma, Shuishen Zhang, Siyi Zheng, Rongsong Ling, K. Sun, Siyao Guo, Boxuan Huang, Yu Liang, Lu Wang, Shuang Chen, Zhaoyu Wang, Wei Wei, Ying Huang, Hao-ran Peng, Yizhou Jiang, Junho Choe, Shuibin Lin   +18 more
semanticscholar   +1 more source

SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

Journal of Translational Medicine, 2021
Background Solute carrier family 7 member 11(SLC7A11) is a component of cysteine/glutamate transporter, which plays a key role in tumor growth; however, its underlying effect on radiosensitivity in esophageal squamous cell carcinoma (ESCC) remains ...
Lei Feng, Kaikai Zhao, Liangchao Sun, Xiao-Xiao Yin, Junpeng Zhang, Conghe Liu, Baosheng Li   +6 more
semanticscholar   +1 more source

Clinical and biomarker analyses of sintilimab versus chemotherapy as second-line therapy for advanced or metastatic esophageal squamous cell carcinoma: a randomized, open-label phase 2 study (ORIENT-2)

Nature Communications, 2021
This randomized, open-label, multi-center phase 2 study (NCT03116152) assessed sintilimab, a PD-1 inhibitor, versus chemotherapy in patients with esophageal squamous cell carcinoma after first-line chemotherapy. The primary endpoint was overall survival (
Jianming Xu, Yi Li, Q. Fan, Y. Shu, Lei Yang, T. Cui, K. Gu, M. Tao, Xiuwen Wang, C. Cui, N. Xu, Juxiang Xiao, Quanli Gao, Yunpeng Liu, Tao Zhang, Yuxian Bai, Wei Li, Yiping Zhang, G. Dai, D. Ma, Jingdong Zhang, C. Bai, Yunchao Huang, W. Liao, Lin Wu, X. Chen, Yan Yang, Junye Wang, Shoujian Ji, Hui Zhou, Yan Wang, Zhuo Ma, Yanqi Wang, B. Peng, Jiya Sun, C. Mancao   +35 more
semanticscholar   +1 more source