Results 11 to 20 of about 337,805 (303)

Multicenter, single-arm, phase II trial of camrelizumab and chemotherapy as neoadjuvant treatment for locally advanced esophageal squamous cell carcinoma

Journal for ImmunoTherapy of Cancer, 2022
Background Camrelizumab and chemotherapy demonstrated durable antitumor activity with a manageable safety profile as first-line treatment in patients with advanced esophageal squamous cell carcinoma (ESCC).
Jun Liu, Yang Yang, Zhichao Liu, Xiao-long Fu, X. Cai, Hong-xuan Li, Li Zhu, Yan Shen, Hong Zhang, Yifeng Sun, Hezhong Chen, Bentong Yu, Renquan Zhang, J. Shao, Ming Zhang, Zhigang Li   +15 more
semanticscholar   +1 more source

Effect of Camrelizumab vs Placebo Added to Chemotherapy on Survival and Progression-Free Survival in Patients With Advanced or Metastatic Esophageal Squamous Cell Carcinoma: The ESCORT-1st Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2021
Importance Standard first-line therapy for advanced or metastatic esophageal carcinoma is chemotherapy, but the prognosis remains poor. Camrelizumab (an anti-programmed death receptor 1 [PD-1] antibody) showed antitumor activity in previously treated ...
Hui‐yan Luo, J. Lu, Yuxian Bai, T. Mao, Jun Wang, Q. Fan, Yiping Zhang, K. Zhao, Zhendong Chen, Shegan Gao, Jiancheng Li, Z. Fu, K. Gu, Zhihua Liu, Lin Wu, Xiaodong Zhang, Jifeng Feng, Z. Niu, Y. Ba, He-long Zhang, Ying Liu, Li Zhang, Xuhong Min, Jing Huang, Ying Cheng, Dong Wang, Yuzhen Shen, Qing Yang, J. Zou, Rui-Hua Xu   +29 more
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Fbxw8 protein promotes the proliferation and metastasis of ESCC [PDF]

E3S Web of Conferences, 2020
Objective: This article plans to investigate Fbxw8 protein expression in esophageal squamous cell carcinoma tissues. And its effect on the proliferation ability of esophageal squamous cancer KYSE70 cells is analyzed.
Gao Shanshan, Zhao Dongdong
doaj   +1 more source

Neoadjuvant programmed cell death 1 blockade combined with chemotherapy for resectable esophageal squamous cell carcinoma

Journal for ImmunoTherapy of Cancer, 2022
Background Programmed cell death 1 (PD-1) blockade induces tumor regression in patients with advanced esophageal squamous cell carcinoma (ESCC); however, little is known about the efficacy of PD-1 blockade as neoadjuvant therapy in resectable ESCC.
Weixiong Yang, Xiangbin Xing, S. Yeung, Siyu Wang, Wenfang Chen, Y. Bao, Fang Wang, S. Feng, F. Peng, Xiaoyan Wang, Shuling Chen, M. He, Ningfang Zhang, Honglei Wang, B. Zeng, Zhenguo Liu, B. Kidane, C. Seder, K. Koyanagi, Y. Shargall, Honghe Luo, S. Peng, Chao Cheng   +22 more
semanticscholar   +1 more source

First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial

Nature Medicine, 2023
First-line systemic therapeutic options for advanced esophageal squamous cell carcinoma (ESCC) are limited. In this multicenter, double-blind phase 3 trial, a total of 551 patients with previously untreated, locally advanced or metastatic ESCC and PD-L1 ...
Yan Song, Bo Zhang, Dao Xin, X. Kou, Zhenbo Tan, Shu Zhang, Meili Sun, Jin Zhou, M. Fan, Ming Zhang, Yongxiang Song, Suyi Li, Yuan Yuan, W. Zhuang, Jingdong Zhang, Li Zhang, Hao Jiang, K. Gu, H. Ye, Yingyue Ke, Jing Li, Qingyu Wang, Jun Zhu, Jing Huang   +23 more
semanticscholar   +1 more source

Diagnosis and Clinical Management of Esophageal Squamous Dysplasia [PDF]

The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2021
Esophageal squamous cell carcinoma is the seventh most common cancer and the sixth most common cause of cancer death worldwide. Esophageal squamous dysplasia is the only histopathology that predicts the development of esophageal squamous cell carcinoma ...
Gwang Ha Kim
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MicroRNAs and Esophageal Squamous Cell Carcinoma [PDF]

Digestion, 2010
Esophageal cancer is a common cause of cancer death worldwide. Esophageal squamous cell carcinoma (ESCC) is the most predominant type. Certain microRNAs (miRNAs) function in tumorgenesis involved in important biological and pathologic processes. To reveal miRNAs’ signatures of ESCC, we analyzed miRNAs extracted from ESCC cell lines with the microRNA ...
Kayoko, Matsushima, Hajime, Isomoto, Shigeru, Kohno, Kazuhiko, Nakao   +3 more
openaire   +2 more sources

Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma.

Cancer Research, 2023
Neoadjuvant chemoimmunotherapy (NACI) has shown promise in the treatment of resectable esophageal squamous cell carcinoma (ESCC). The microbiomes of patients can impact therapy response, and previous studies have demonstrated that intestinal microbiota ...
Hong Wu, X. Leng, Qianshi Liu, Tianqin Mao, Tao Jiang, Yiqiang Liu, Feifei Li, Chenhui Cao, Jun Fan, Liang Chen, Yaqi Chen, Qingjiang Yao, S. Lu, Renchuan Liang, Lanlin Hu, Mingxin Liu, Yejian Wan, Zhaoshen Li, Jun Peng, Qiyu Luo, Hang Zhou, Jun Yin, Ke Xu, Mei Lan, Xinhao Peng, Haitao Lan, Gang Li, Yongtao Han, Xia Zhang, Z. Xiao, J. Lang, Guihua Wang, Chuan Xu   +32 more
semanticscholar   +1 more source

Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma.

Cancer Cell, 2023
Neoadjuvant immune checkpoint blockade (ICB) demonstrates promise in operable esophageal squamous cell carcinoma (ESCC), but lacks available efficacy biomarkers.
Zhichao Liu, Yaru Zhang, Ning Ma, Yang Yang, Yunlong Ma, Feng Wang, Yan Wang, Jinzhi Wei, Hongyan Chen, A. Tartarone, J. Velotta, F. Dayyani, Emmanuel M. Gabriel, Connor J. Wakefield, B. Kidane, C. Carbonelli, Lingyun Long, Zhihua Liu, Jianzhong Su, Zhigang Li   +19 more
semanticscholar   +1 more source

A novel pyroptosis scoring model was associated with the prognosis and immune microenvironment of esophageal squamous cell carcinoma

Frontiers in Genetics, 2023
The phenotype of pyroptosis has been extensively studied in a variety of tumors, but the relationship between pyroptosis and esophageal squamous cell carcinoma (ESCC) remains unclear. Here, 22 pyroptosis genes were downloaded from the website of Gene Set
Zhan-Fei Zhang, Zhan-Fei Zhang
doaj   +1 more source