Results 81 to 90 of about 337,805 (303)

Etiology and chemoprevention of esophageal squamous cell carcinoma [PDF]

Carcinogenesis, 2001
Squamous cell carcinoma (SCC) of the human esophagus has a multifactorial etiology involving several environmental and/or genetic factors. Current modalities of therapy for this disease offer poor survival and cure rates. Although a number of approaches could be undertaken to reduce the occurrence of esophageal SCC, including changes in lifestyle and ...
G D, Stoner, A, Gupta
openaire   +2 more sources

Phase II clinical trial using camrelizumab combined with apatinib and chemotherapy as the first‐line treatment of advanced esophageal squamous cell carcinoma

Cancer Communications, 2020
Effective therapeutic options are limited for patients with advanced esophageal squamous cell carcinoma (ESCC). The incorporation of an immune checkpoint inhibitor and a molecular anti‐angiogenic agent into the commonly adopted chemotherapy may produce ...
Bo Zhang, L. Qi, Xi Wang, Jian‐ping Xu, Yun Liu, L. Mu, Xingyuan Wang, Lidan Bai, Jing Huang   +8 more
semanticscholar   +1 more source

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

PTK7 is a novel oncogenic target for esophageal squamous cell carcinoma

World Journal of Surgical Oncology, 2017
Background Overexpression of PTK7 has been found in multiple cancers and has been proposed to serve as a prognostic marker for intrahepatic cholangiocarcinoma. Its role in esophageal cancer, however, remains to be clarified.
Kang Liu, Guiqin Song, Xuqian Zhang, Qiujiang Li, Yunxia Zhao, Yuchuan Zhou, Rong Xiong, Xin Hu, Zhirong Tang, Gang Feng   +9 more
doaj   +1 more source

Porphyromonas gingivalis promotes tumor progression in esophageal squamous cell carcinoma

Cellular Oncology, 2020
Increasing evidence indicates that the microbiome may influence tumor growth and modulate the tumor microenvironment of gastrointestinal cancers. However, the role of oral bacteria in the development of esophageal squamous cell carcinoma (EsoSCC) has ...
Miao-Fen Chen, Ming-Shian Lu, Ching-Chuan Hsieh, Wen-Cheng Chen   +3 more
semanticscholar   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan, Yitong Li, Yufei Wu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang   +6 more
wiley   +1 more source

The significance of CD4+ and CD8+ T lymphocyte infiltration in esophageal squamous cell carcinoma

Indian Journal of Pathology and Microbiology
Purpose: To investigate the relationship between the abundance of CD4+ and CD8+ T cells in the tumor microenvironment and the prognosis of patients with esophageal squamous cell carcinoma, and to analyze their correlation and explore its clinical value ...
Jiang Y. Zhao, Xiaojun Pang, Jiao Peng, Jingtao Liu, Qiang Deng, Shunhai Jian   +5 more
doaj   +1 more source

Biomass fuel as a risk factor for esophageal squamous cell carcinoma: a systematic review and meta-analysis

Environmental Health, 2019
Background The link between use of solid biomass fuel (wood, charcoal, coal, dung, and crop residues) for cooking and/or heating and esophageal squamous cell carcinoma (ESCC) is inconclusive.
Samson Okello, Suzan Joan Akello, Emmanuel Dwomoh, Emmanuel Byaruhanga, Christopher Kenneth Opio, Ruyang Zhang, Kathleen E. Corey, Winnie R. Muyindike, Ponsiano Ocama, David D. Christiani   +9 more
doaj   +1 more source

Difference in Intestinal Flora Among Patients with Esophageal Squamous Cell Carcinoma and Normal Population

Zhongliu Fangzhi Yanjiu, 2023
Objective To investigate the difference in intestinal flora among patients with esophageal squamous cell carcinoma and normal population and to provide a basis for the early diagnosis of esophageal squamous cell carcinoma as a marker.
CAO Yanzhen, TUSUNAYI·Wumaier, HU Jiajie, YANG Lili, FANG Xinzhi   +4 more
doaj   +1 more source