Results 71 to 80 of about 141,634 (350)

A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β

Advanced Science, EarlyView.
This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.
Fan Luo, Ting Yang, Jiaxin Cao, Qun Chen, Zhenhai Lu, Feiteng Lu, Chaozhuo Lin, Zengfei Xia, Yuanzhong Yang, Peng Li, Wenjuan Ma, Min Luo, Rongxin Zhang   +12 more
wiley   +1 more source

Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications. [PDF]

, 2014
Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival.
Bonavida, Benjamin, Shvartsur, Anna
core   +7 more sources

ESOPHAGEAL SQUAMOUS CELL CARCINOMA

, 2019
The esophageal cancer is one of the fatal malignancies around the world, with a dramatic increase in incidence rates in the Western world occurring over the past few decades. Esophageal cancer is the 8th most common cancer and the 6th most common cause of cancer deaths worldwide despite improvements in the management and the therapeutic approach.
openaire   +2 more sources

Real‐Time In Vivo Cellular‐Level Imaging During Puncture

Advanced Science, EarlyView.
We present an artificial‐intelligence‐empowered integrative‐light‐field microendoscopy (AIM) needle that delivers real‐time in vivo, diffraction‐limited cellular‐level imaging during puncture and visualizes layered microstructures along the needle path. As a microscopic complement to CT/ultrasound, it improves sampling localization and adds preliminary
Huifang Gao, Jiakang Shao, Quanzhi Li, Yizhou Tan, Liangliang Huang, Xiaorong Xu, Ji Qi, Julin Xiao, Wenwen Li, Zhong Wen, Le Wang, Xu Liu, Qing Yang, Ying Gu   +13 more
wiley   +1 more source

Nipped-B-like Protein Sensitizes Esophageal Squamous Cell Carcinoma Cells to Cisplatin via Upregulation of PUMA

Technology in Cancer Research & Treatment, 2020
Nipped-B-like protein plays a pivotal role as a cohesin loading factor in the segregation of chromosomes when cells divide. Accumulating evidence indicates that alterations of this protein are involved in human carcinogenesis, especially in the ...
Shengjie Zhang PhD, Yun Zhou BM, Qinchuan Wang MD, PhD, Kristine Donahue PhD, Jianguo Feng MMed, Yinli Yao MMed, Aiping Chen PhD, Xia Li PhD, Lianlian Hong PhD   +8 more
doaj   +1 more source

The pathologists’ eyes on foregut: histopathological relations in the experimental and routine diagnostics [PDF]

, 2011
SUMMARY I. The study aimed to investigate the incidence of duodeno-gastroesophageal reflux-induced malignoma formation in a series of duodeno-esophageal anastomosis operations in rats.
Németh István Balázs
core  

Outcomes and Prognostic Factors of Salvage Radiation for Postoperative Lymph Node Recurrence of Esophageal Squamous Cell Carcinoma [PDF]

, 2021
Chi Zhang, Xiaolin Ge, Chenjun Huang, Shu Zhang, Xinchen Sun   +4 more
openalex   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Automatic detection of squamous cell carcinoma metastasis in esophageal lymph nodes using semantic segmentation

Clinical and Translational Medicine, 2020
Esophageal squamous cell carcinoma (ESCC) is more prevalent than esophageal adenocarcinoma in Asia, especially in China, where more than half of ESCC cases occur worldwide.
Yi Pan, Zhuo Sun, Wenmiao Wang, Zhaoyang Yang, Jia Jia, Xiaolong Feng, Yaxi Wang, Qing Fang, Jiangtao Li, Hongtian Dai, Calvin Ku, Shuhao Wang, Cancheng Liu, Liyan Xue, Ning Lyu, Shuangmei Zou   +15 more
doaj   +1 more source

Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo. [PDF]

, 2015
BACKGROUND: Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency.
Alder, Hansjuerg, Chen, Hongping, Croce, Carlo M., Di Leva, Gianpiero, Fadda, Paolo, Farber, John L., Fong, Louise, Garofalo, Michela, Jiang, Yubao, Middleton, Justin, Naidu, Srivatsava, Selmi, Tommaso, Smalley, Karl J., Taccioli, Cristian, Tagliazucchi, Guidantonio Malagoli   +14 more
core   +1 more source