Results 21 to 30 of about 6,072 (179)

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Lifestyle Factors Associated With Reflux Symptoms Without Erosive Esophagitis in Japanese Individuals With and Without Obesity Undergoing Health Checkups: A Cross‐Sectional Study

Journal of General and Family Medicine, Volume 27, Issue 5, September 2026.
ABSTRACT Background Non‐erosive reflux disease (NERD) is the most prevalent gastroesophageal reflux disease phenotype. However, lifestyle factors associated with reflux symptoms in the absence of erosive esophagitis, a presentation often classified as NERD in epidemiological studies, remain underexplored in Japan.
Seiji Shiota, Yukino Himeji, Mako Miura, Ryo Goto, Yuki Tsutsui, Yuki Eto, Noboru Horinouchi, Rie Utsunomiya, Eri Doi, Katsuhiko Yoshimura, Kyoko Yamamoto   +10 more
wiley   +1 more source

Lack of Effect of H2-Receptor Antagonists and Antacids on the Gastric and Duodenal Gastrin-, Somatostatin- and Serotonin-Producing Cells in Patients with Acid Peptic Disorders

Canadian Journal of Gastroenterology, 1996
Standard therapeutic approaches to acid peptic disorders have dealt with neutralizing or inhibiting aggressive factors and/or bolstering defensive factors.
WR Yacoub, ABR Thomson, P Hooper, LD Jewell   +3 more
doaj   +1 more source

Efficacy and Tolerability of Tegoprazan Compared to Proton Pump Inhibitors in the Treatment of Erosive Esophagitis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

JGH Open, Volume 10, Issue 8, August 2026.
ABSTRACT Aim Tegoprazan, a potassium‐competitive acid blocker, is an acid‐suppressing medication under review as a potential alternative treatment in cases of erosive esophagitis. This systematic review and meta‐analysis assesses the efficacy and tolerability of tegoprazan compared to proton pump inhibitors, the current standard of care. Methods Pubmed,
Youssef Diab, Charbel Maalouf, Anthony Junior Al Hakim, Perla Chami, Ali Ghais, Etwal Bou Raad, Louis Chaptini   +6 more
wiley   +1 more source

Peptic ulcer disease: Insights and risk factors

JPGN Reports, Volume 7, Issue 3, Page 403-409, August 2026.
Abstract Objectives Peptic ulcer disease (PUD), affects adults and children, with Helicobacter pylori (H. pylori) infection being the most frequent cause. Diagnosis requires an upper gastrointestinal endoscopy (UGE) and invasive tests. However, besides H. pylori, risk factors for PUD in children remain unclear.
Haidar Houmani, Islam Saidi, Meline M'rini, Julie Nguyen, Assaad Salame, Patrick Bontems, Kallirroi Kotilea   +6 more
wiley   +1 more source

Review – H. pylori and non-malignant diseases [PDF]

Microbiota in Health and Disease
The article considers the role of Helicobacter pylori (H. pylori) in the formation and progression of non-malignant diseases of the upper gastrointestinal tract and reviews the results of studies published in the period from April 2023 to May 2024.
D. Bordin, M. Livzan, O. Gaus, S. Mozgovoi   +3 more
doaj   +1 more source

Gastric duplication cyst causing hypergastrinemia in an infant

JPGN Reports, Volume 7, Issue 3, Page 428-431, August 2026.
Abstract Gastric duplication cysts are rare congenital anomalies, with fewer than 10% occurring in the stomach. We report a 14‐month‐old girl presenting with failure to thrive, recurrent emesis, hematemesis, and severe duodenitis with ulceration. Laboratory evaluation revealed marked hypergastrinemia (1781 pg/mL), and initial imaging was unrevealing ...
Nathan Bryan, Ian Leibowitz
wiley   +1 more source

The Value of Alarm Features in Identifying Organic Causes of Dyspepsia

Canadian Journal of Gastroenterology, 2000
The unaided clinical diagnosis of dyspepsia is of limited value in separating functional dyspepsia from clinically relevant organic causes of dyspepsia (gastric and esophageal malignancies, peptic ulcer disease and complicated esophagitis).
Lone Galmstrup Madsen, Peter Bytzer
doaj   +1 more source

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, Volume 81, Issue 8, Page 2775-2791, August 2026.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

FREQUENCY OF PEPTIC ULCER DISEASE IN PATIENTS OF DYSPEPSIA AN ANALYSIS OF UPPER GASTROINTESTINAL ENDOSCOPY

Pakistan Armed Forces Medical Journal, 2010
Objective: To evaluate the frequency of peptic ulcer disease in patients of dyspepsia on upper gastrointestinal endoscopy. Study Design: Descriptive study Place and Duration of study: The study was conducted at Combined Military Hospital, Multan ...
Maj Syed Onaiz Anwar, Shumaila Ambreen, Hafiz Muhammad Ashraf   +2 more
doaj   +2 more sources