Results 51 to 60 of about 378,407 (392)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Review of esophageal injuries and stenosis: Lessons learn and current concepts of management

Journal of Indian Association of Pediatric Surgeons, 2016
Aim: To review the patients with esophageal injuries and stenosis with respect to their etiology, clinical course, management, and the lessons learnt from these.
Raghu Sampalli Ramareddy, Anand Alladi
doaj   +1 more source

Microbial Similarity and Preference for Specific Sites in Healthy Oral Cavity and Esophagus

Frontiers in Microbiology, 2018
Human microbial communities are highly complex ecosystems, but it remains unclear if microbial compositions have any similarity in distinct sites of the oral cavity and esophagus in particular.
Li Dong, J. Yin, J. Zhao, Shanrui Ma, Hai-rui Wang, Meng Wang, W. Chen, Wenqiang Wei   +7 more
semanticscholar   +1 more source

An investigation of the progression from Barrett's esophagus to adenocarcinoma [PDF]

, 2016
Barrett's esophagus is a metaplasia of the epithelium of the lower esophagus from a normal squamous appearance to a columnar appearance more typically found in the stomach. It is normally caused by prolonged gastric reflux. While Barrett's esophagus is
Palmese, Scott Joseph
core   +1 more source

Recurrence of intestinal metaplasia and early neoplasia after endoscopic eradication therapy for Barrett’s esophagus: A systematic review and meta-analysis [PDF]

, 2017
Background Conflicting data exist with regard to recurrence rates of intestinal metaplasia (IM) and dysplasia after achieving complete eradication of intestinal metaplasia (CE-IM) in Barrett’s esophagus (BE) patients.
Cinnor, Birtukan, Das, Ananya, Early, Dayna S, Edmundowicz, Steven A, Fujii-Lau, Larissa L, Gaddam, Srinivas, Komanduri, Srinadh, Kushnir, Vladimir, Mullady, Daniel, Muthusamy, V. Raman, Shaheen, Nicholas, Simon, Violette C, Wani, Sachin, Wilson, Robert   +13 more
core   +2 more sources

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Optimizing Storage and Computational Efficiency: An Efficient Algorithm for Whole Slide Image Size Reduction

Mayo Clinic Proceedings: Digital Health, 2023
Objective: To efficiently store, transfer, and analyze whole slide imaging (WSI), we developed an image-processing algorithm to remove the unneeded background in a WSI and assemble tissue-containing parts into smaller WSIs without any change in tissue ...
Shahriar Faghani, MD, D. Chamil Codipilly, MD, Mana Moassefi, MD, Prasad G. Iyer, MD, Bradley J. Erickson, MD, PhD   +4 more
doaj  

Body Mass Index, Smoking, and Alcohol and Risks of Barrett’s Esophagus and Esophageal Adenocarcinoma: A UK Prospective Cohort Study [PDF]

, 2014
BACKGROUND: The timing of the risk factors cigarette smoking, alcohol and obesity in the development of Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) is unclear.
Cheong, Edward, Fitzgerald, Rebecca, Hart, Andrew, Igali, Laszlo, Khaw, Kay-tee, Luben, Robert, Yates, Max   +6 more
core   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Paired Exome Analysis of Barrett’s Esophagus and Adenocarcinoma

Nature Genetics, 2015
Barrett's esophagus is thought to progress to esophageal adenocarcinoma (EAC) through a stepwise progression with loss of CDKN2A followed by TP53 inactivation and aneuploidy.
M. Stachler, A. Taylor-Weiner, Shouyong Peng, A. McKenna, A. Agoston, R. Odze, J. Davison, K. Nason, M. Loda, I. Leshchiner, C. Stewart, P. Stojanov, Sara Seepo, M. Lawrence, Daysha Ferrer-Torres, Jules Lin, A. Chang, S. Gabriel, E. Lander, D. Beer, G. Getz, S. Carter, A. Bass   +22 more
semanticscholar   +1 more source