Results 71 to 80 of about 4,819,037 (269)

Essential trace elements in meat, spleen and liver of Brahman Cross steers reared in intensive production system in Bandung, Indonesia

Journal of the Indonesian Tropical Animal Agriculture, 2018
In this study the determination of micro mineral elements (selenium, iron and zinc) in meat, spleen and liver of beef were carried out. Brahman cross steers reared under intensive production system in feedlot for 87 days.
D. D. Lestiani, M. Santoso, E. Y. Setyowati, S. Kurniawati, N. Adventini, E. Damastuti   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Essential Spectrum of the Essentially Isometric Operator

Canadian Mathematical Bulletin, 2014
AbstractLet T be a contraction on a complex, separable, infinite dimensional Hilbert space and let σ(T) (resp. σe(T)) be its spectrum (resp. essential spectrum). We assume that T is an essentially isometric operator; that is, IH -T*T is compact. We show that if D\σ(T) ≠ Ø, then for every f from the disc-algebraσe(f(T)) = f(σe(T))where D is the open ...
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hypoxemia detection and oxygen therapy practices in neonatal and pediatric wards across seven district and referral hospitals in Rwanda

Frontiers in Pediatrics
BackgroundHypoxemia, characterized by low levels of oxygen in the blood, is a potentially fatal condition that is commonly found in pediatric and neonatal conditions that drive childhood mortality globally.
Hyacinthe Mushumbamwiza, Harriet H. Webster, Christine Kayitesi, Jasmine Miller, Nang’andu Chizyuka, Felix Musabirema, Alida Ngwije, Brenda Kateera, Sanctus Musafiri, Lisine Tuyisenge, Hamish R. Graham, Felix Lam, Corneille Ntihabose   +12 more
doaj   +1 more source

How essential are essential fatty acids?

Journal of the American Oil Chemists' Society, 1978
The present article analyzes the symptoms of essential fatty acid deficiency, both in human beings and in animals. The first part of the article describes the interrelationships between linoleic, linolenic and arachidonic acids, and how these acids affect the physiological response in experimental animals.
openaire   +3 more sources