Results 101 to 110 of about 2,035,370 (389)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population

Metabolites, 2019
We aimed to simultaneously examine the associations of both essential and non-essential amino acids with both prevalent and incident type 2 diabetes in a Chinese population.
Yonghai Lu, Yeli Wang, Xu Liang, Li Zou, Choon Nam Ong, Jian-Min Yuan, Woon-Puay Koh, An Pan   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The effect of oral essential amino acids on incretin hormone production in youth and ageing

, 2019
BackgroundThe effect of substantive doses of essential amino acids (EAA) on incretin and insulin production, and the impact of age upon this effect, is ill‐defined.MethodsA 15‐g oral EAA drink was administered to young (N = 8; 26 ± 4.4 years) and older ...
Stokes, Tanner, Stefan H.M. Gorissen (12591649), Abdulla, H., Stuart M. Phillips, Stefan H. M. Gorissen, Stuart M. Phillips (261257), Bass, J.J., Chris McGlory (6939368), Gorissen, Stefan H M, Gorissen, S.H.M., Smith, Kenneth, Bethan E. Phillips, Abdulla, Haitham, Atherton, Philip J, Haitham Abdulla, Tanner Stokes, McGlory, C., Iskandar Idris, Joseph J. Bass (12591379), Phillips, Stuart M, Tanner Stokes (10488638), Kenneth Smith, Kenneth Smith (149075), Smith, K., McGlory, Chris, Stokes, T., Chris McGlory, Idris, Iskandar, Bethan E. Phillips (8620080), Idris, I., Phillips, B.E., Phillips, Bethan E, Phillips, S.M., Haitham Abdulla (12591646), Philip J. Atherton (7240463), Bass, Joseph J, Philip J. Atherton, Joseph J. Bass, Iskandar Idris (2564347), Atherton, P.J.   +39 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Species Variations in the Proximate Composition, Amino Acid Profile, and Protein Quality of the Muscle Tissue of Grass Carp, Bighead Carp, Siberian Sturgeon, and Wels Catfish

Journal of Food Quality, 2018
This study determined the proximate composition, energy value, amino acid profile, and protein quality of the muscle tissue of four food fish species. The fish analyzed contained 78.90–69.89% water, 18.25–15.69% protein, and 2.28–12.57% fat.
Renata Pyz-Łukasik, Waldemar Paszkiewicz   +1 more
doaj   +1 more source

Essential Amino Acids—Essential in Arterial Thrombosis [PDF]

Circulation, 2020
Zachary T, Hilt, Craig N, Morrell
openaire   +2 more sources

Endosymbiosis in trypanosomatids: the genomic cooperation between bacterium and host in the synthesis of essential amino acids is heavily influenced by multiple horizontal gene transfers

BMC Evolutionary Biology, 2013
Trypanosomatids of the genera Angomonas and Strigomonas live in a mutualistic association characterized by extensive metabolic cooperation with obligate endosymbiotic Betaproteobacteria.
J. Alves, C. Klein, F. M. da Silva, Andre G. Costa-Martins, M. Serrano, G. Buck, A. T. Vasconcelos, M. Sagot, M. Teixeira, M. Motta, E. Camargo   +10 more
semanticscholar   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

CHEMICAL COMPOSITION AND AMINO ACID PROFILE OF FRESH AND STEAMED COBIA (Rachycentron canadum L.)

Food ScienTech Journal, 2020
Cobia (Rachycentron canadum) is economically important fish with good prospects because of fast growing and easily cultured. Cobia is usually processed by many methods including steaming.
Nurjanah Nurjanah, Ruddy Suwandi, Taufik Hidayat, Vini Oktorina   +3 more
doaj   +1 more source